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Article: Neovascularization and bone formation in the condyle during stepwise mandibular advancement

TitleNeovascularization and bone formation in the condyle during stepwise mandibular advancement
Authors
Issue Date2004
PublisherOxford University Press. The Journal's web site is located at http://ejo.oxfordjournals.org/
Citation
European Journal Of Orthodontics, 2004, v. 26 n. 2, p. 137-141 How to Cite?
AbstractThe aims of this investigation were to identify the temporal expression of vascular endothelial growth factor (VEGF) in the mandibular condyle and to correlate it with the pattern of new bone formation during stepwise mandibular advancement. Two hundred and fifty female, 35-day-old Sprague-Dawley rats were randomly divided into 10 groups, with 10 rats allocated to the single-step bite-jumping subgroup, 10 rats to the stepwise advancement subgroup and five rats to the control subgroup. In the experimental groups, the mandibles were kept in a continuous forward position. The initial stepwise advancement commenced on day 35, whereas the second advancement started on day 65. The rats were sacrificed on experimental days 3, 7, 14, 21, 30, 33, 37, 44, 51 and 60. Sections (7 μm) were cut through the condyle in the parasagittal plane and stained with anti-VEGF antibody. Each section was counter-stained with haematoxylin for observation of the cellular response. The sections were digitized and quantitatively analysed with a computer-assisted image analysing system. The results showed that the initial advancement in the stepwise group led to significantly less expression of VEGF when compared with single advancement. However, the second advancement on day 30 resulted in a significant increase in VEGF expression when compared with the one-step group and the natural growth control group. Thus, it was concluded that changes in the amplitude of mechanical loading, produced by stepwise advancement, have a significant effect on the production of VEGF by the chondrocytes. During the later stages of advancement, more VEGF and more condylar bone was produced. © European Orthodontic Society 2004; all rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/66380
ISSN
2015 Impact Factor: 1.44
2015 SCImago Journal Rankings: 1.090
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, FYCen_HK
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorHägg, Uen_HK
dc.date.accessioned2010-09-06T05:45:52Z-
dc.date.available2010-09-06T05:45:52Z-
dc.date.issued2004en_HK
dc.identifier.citationEuropean Journal Of Orthodontics, 2004, v. 26 n. 2, p. 137-141en_HK
dc.identifier.issn0141-5387en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66380-
dc.description.abstractThe aims of this investigation were to identify the temporal expression of vascular endothelial growth factor (VEGF) in the mandibular condyle and to correlate it with the pattern of new bone formation during stepwise mandibular advancement. Two hundred and fifty female, 35-day-old Sprague-Dawley rats were randomly divided into 10 groups, with 10 rats allocated to the single-step bite-jumping subgroup, 10 rats to the stepwise advancement subgroup and five rats to the control subgroup. In the experimental groups, the mandibles were kept in a continuous forward position. The initial stepwise advancement commenced on day 35, whereas the second advancement started on day 65. The rats were sacrificed on experimental days 3, 7, 14, 21, 30, 33, 37, 44, 51 and 60. Sections (7 μm) were cut through the condyle in the parasagittal plane and stained with anti-VEGF antibody. Each section was counter-stained with haematoxylin for observation of the cellular response. The sections were digitized and quantitatively analysed with a computer-assisted image analysing system. The results showed that the initial advancement in the stepwise group led to significantly less expression of VEGF when compared with single advancement. However, the second advancement on day 30 resulted in a significant increase in VEGF expression when compared with the one-step group and the natural growth control group. Thus, it was concluded that changes in the amplitude of mechanical loading, produced by stepwise advancement, have a significant effect on the production of VEGF by the chondrocytes. During the later stages of advancement, more VEGF and more condylar bone was produced. © European Orthodontic Society 2004; all rights reserved.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://ejo.oxfordjournals.org/en_HK
dc.relation.ispartofEuropean Journal of Orthodonticsen_HK
dc.rightsEuropean Journal of Orthodontics. Copyright © Oxford University Press.en_HK
dc.titleNeovascularization and bone formation in the condyle during stepwise mandibular advancementen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0141-5387&volume=26 No3&spage=137&epage=141&date=2004&atitle=Neovascularization+and+bone+formation+in+the+condyle+during+stepwise+mandibular+advancementen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.emailHägg, U: euohagg@hkusua.hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.identifier.authorityHägg, U=rp00020en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/ejo/26.2.137en_HK
dc.identifier.scopuseid_2-s2.0-2942696605en_HK
dc.identifier.hkuros95056en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2942696605&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume26en_HK
dc.identifier.issue2en_HK
dc.identifier.spage137en_HK
dc.identifier.epage141en_HK
dc.identifier.isiWOS:000220486200003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLeung, FYC=36103875400en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridHägg, U=7006790279en_HK

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