File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Effect of Salvia miltiorrhiza extract on bone formation

TitleEffect of Salvia miltiorrhiza extract on bone formation
Authors
KeywordsBone graft
Bone repair
Danshen
Salvia miltiorrhiza
Issue Date2008
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304/
Citation
Journal Of Biomedical Materials Research - Part A, 2008, v. 85 n. 2, p. 506-512 How to Cite?
AbstractSalvia miltiorrhiza (SM) is a Chinese medicine used for treatment of cardiac diseases through improving blood circulation. Our laboratory compared the amount of new bone formed in collagen matrix with SM extract to that formed in the collagen matrix alone. Eighteen bone defects, 5 mm x 10 mm were created in the parietal bone of nine New Zealand White rabbits. In the experimental group, six defects were grafted with collagen matrix with SM extract. In the control groups, six defects were grafted with collagen matrix alone (positive control) and six were left empty (negative control). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Serial sections were cut across each defect. Quantitative analysis of new bone formation was made on 100 sections (50 sections for each group of SM and positive control) using image analysis. A total of 478% more new bone was present in defects grafted with SM extract in collagen matrix than those grafted with the collagen matrix alone. Very little new bone was formed in the passive control group. In conclusion, SM extract in collagen matrix has the effect of increasing new bone formation locally and can be used for bone grafting especially in cases with compromised vascular responses. © 2007 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/66363
ISSN
2015 Impact Factor: 3.263
2015 SCImago Journal Rankings: 0.979
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2010-09-06T05:45:44Z-
dc.date.available2010-09-06T05:45:44Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Biomedical Materials Research - Part A, 2008, v. 85 n. 2, p. 506-512en_HK
dc.identifier.issn1549-3296en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66363-
dc.description.abstractSalvia miltiorrhiza (SM) is a Chinese medicine used for treatment of cardiac diseases through improving blood circulation. Our laboratory compared the amount of new bone formed in collagen matrix with SM extract to that formed in the collagen matrix alone. Eighteen bone defects, 5 mm x 10 mm were created in the parietal bone of nine New Zealand White rabbits. In the experimental group, six defects were grafted with collagen matrix with SM extract. In the control groups, six defects were grafted with collagen matrix alone (positive control) and six were left empty (negative control). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Serial sections were cut across each defect. Quantitative analysis of new bone formation was made on 100 sections (50 sections for each group of SM and positive control) using image analysis. A total of 478% more new bone was present in defects grafted with SM extract in collagen matrix than those grafted with the collagen matrix alone. Very little new bone was formed in the passive control group. In conclusion, SM extract in collagen matrix has the effect of increasing new bone formation locally and can be used for bone grafting especially in cases with compromised vascular responses. © 2007 Wiley Periodicals, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304/en_HK
dc.relation.ispartofJournal of Biomedical Materials Research - Part Aen_HK
dc.rightsJournal of Biomedical Materials Research Part A. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectBone graften_HK
dc.subjectBone repairen_HK
dc.subjectDanshenen_HK
dc.subjectSalvia miltiorrhizaen_HK
dc.subject.meshBone Transplantation-
dc.subject.meshCollagen - pharmacology-
dc.subject.meshDrugs, Chinese Herbal - pharmacology-
dc.subject.meshOsteogenesis - drug effects-
dc.subject.meshParietal Bone - injuries - pathology-
dc.titleEffect of Salvia miltiorrhiza extract on bone formationen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, RWK: fyoung@hku.hken_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jbm.a.31577en_HK
dc.identifier.pmid17729265-
dc.identifier.scopuseid_2-s2.0-42149183172en_HK
dc.identifier.hkuros143941en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-42149183172&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume85en_HK
dc.identifier.issue2en_HK
dc.identifier.spage506en_HK
dc.identifier.epage512en_HK
dc.identifier.isiWOS:000254801700025-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, RWK=7402127170en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats