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Article: Impact of brief, sequential exposure to fluconazole and amphotericin B on the cell surface hydrophobicity of oral Candida albicans isolates obtained from HIV infected patients

TitleImpact of brief, sequential exposure to fluconazole and amphotericin B on the cell surface hydrophobicity of oral Candida albicans isolates obtained from HIV infected patients
Authors
KeywordsAmphotericin B
Candida
Cell surface hydrophobicity
Fluconazole
Issue Date2002
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/0891060x.asp
Citation
Microbial Ecology In Health And Disease, 2002, v. 14 n. 3, p. 153-159 How to Cite?
AbstractCell surface hydrophobicity (CSH) status influences the virulence of Candida albicans isolates and is inextricably involved in candidal adhesion to mucosal and solid surfaces. As the concentration of antimycotic agents reach sub-therapeutic levels at dosage intervals in the oral cavity, the impact of fluconazole and amphotericin B on the CSH of oral C. albicans isolates obtained from Human Immunodeficiency Virus (HIV) infected patients, should be of clinical relevance. Hence, we evaluated using an aqueous-hydrocarbon assay, the CSH of 1,1 isolates of C. albicans following limited (1 hour), sequential (10 days) exposure of the isolates to sub-therapeutic concentrations of fluconazole and amphotericin B. Next, we analyzed the growth curves (computerized turbidometric measurement) of these isolates following such repeated exposure to the antifungals. The reduction in CSH following exposure to fluconazole and amphotericin B was 6.15% (p < 0.05 for 18.18% of the isolates) and 22.80% (p < 0.05 for 54.54% of the isolates), respectively. Analysis of growth curves indicated that the drugs were able to produce a significant fungistatic effect on two of the 11 isolates compared with the controls. Taken together, these data elucidate further pharmacodynamic mechanisms by which antimycotics may operate in vivo in modulating candidal virulence.
Persistent Identifierhttp://hdl.handle.net/10722/66314
ISSN
1998 Impact Factor: 0.605
2012 SCImago Journal Rankings: 0.281
References

 

DC FieldValueLanguage
dc.contributor.authorEllepola, ANBen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.date.accessioned2010-09-06T05:45:19Z-
dc.date.available2010-09-06T05:45:19Z-
dc.date.issued2002en_HK
dc.identifier.citationMicrobial Ecology In Health And Disease, 2002, v. 14 n. 3, p. 153-159en_HK
dc.identifier.issn0891-060Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/66314-
dc.description.abstractCell surface hydrophobicity (CSH) status influences the virulence of Candida albicans isolates and is inextricably involved in candidal adhesion to mucosal and solid surfaces. As the concentration of antimycotic agents reach sub-therapeutic levels at dosage intervals in the oral cavity, the impact of fluconazole and amphotericin B on the CSH of oral C. albicans isolates obtained from Human Immunodeficiency Virus (HIV) infected patients, should be of clinical relevance. Hence, we evaluated using an aqueous-hydrocarbon assay, the CSH of 1,1 isolates of C. albicans following limited (1 hour), sequential (10 days) exposure of the isolates to sub-therapeutic concentrations of fluconazole and amphotericin B. Next, we analyzed the growth curves (computerized turbidometric measurement) of these isolates following such repeated exposure to the antifungals. The reduction in CSH following exposure to fluconazole and amphotericin B was 6.15% (p < 0.05 for 18.18% of the isolates) and 22.80% (p < 0.05 for 54.54% of the isolates), respectively. Analysis of growth curves indicated that the drugs were able to produce a significant fungistatic effect on two of the 11 isolates compared with the controls. Taken together, these data elucidate further pharmacodynamic mechanisms by which antimycotics may operate in vivo in modulating candidal virulence.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/0891060x.aspen_HK
dc.relation.ispartofMicrobial Ecology in Health and Diseaseen_HK
dc.rightsMicrobial Ecology in Health & Disease. Copyright © Informa Healthcare.en_HK
dc.subjectAmphotericin Ben_HK
dc.subjectCandidaen_HK
dc.subjectCell surface hydrophobicityen_HK
dc.subjectFluconazoleen_HK
dc.titleImpact of brief, sequential exposure to fluconazole and amphotericin B on the cell surface hydrophobicity of oral Candida albicans isolates obtained from HIV infected patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0891-060X&volume=00&spage=&epage=&date=2002&atitle=Impact+of+Brief,+Sequential+Exposure+to+Fluconazole+and+Amphotericin+B+on+the+Cell+Surface+Hydrophobicity+of+oral+Candida+albicans+Isolates+Obtained+from+HIV+Infected+Patientsen_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/089106002320644339en_HK
dc.identifier.scopuseid_2-s2.0-0036759053en_HK
dc.identifier.hkuros75033en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036759053&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue3en_HK
dc.identifier.spage153en_HK
dc.identifier.epage159en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridEllepola, ANB=6604060863en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK

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