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Article: Factors regulating condylar cartilage growth under repeated load application

TitleFactors regulating condylar cartilage growth under repeated load application
Authors
KeywordsCartilage
Condyles
Mechanical
PTHrP
RT-PCR
SOX9
Stress
Issue Date2006
PublisherFrontiers in Bioscience. The Journal's web site is located at http://www.frontbiosci.org/
Citation
Frontiers In Bioscience, 2006, v. 11 n. 1 P.889-1198, p. 949-954 How to Cite?
AbstractMechanical loading can influence the biological behavior of the bone-associated cells leading to adaptive changes in skeletal mass and architecture. SOX9 and PTHrP genes are known to regulate chondrocyte differentiation and delay maturation, ultimately control the endochondral bone formation. To investigate the effects of repeated mechanical loading on bone, 280 Sprague-Dawley rats were used in this experiment. The animals were randomly allocated into experimental and control groups. Repeated mechanical loading was applied through a bite-jumping device in the experimental group. The experimental animals were sacrificed on 10 different time points together with the matched control. Total RNA was extracted from the mandibular condylar cartilage for PTHrP and SOX9 genes quantification using real-time RT-PCR. Results showed that PTHrP expression was increased and reached a peak level on the seventh day after mechanical loading was given. Repeated mechanical loading triggered a significant increase of PTHrP expression leading to another peak increment. The expression of SOX9 was highly correlated with the PTHrP expression, and its pattern of expression was similar to that of PTHrP after repeated mechanical loading. In conclusions, repeated mechanical loading on the condyle triggers the expression of PTHrP and SOX9, which in turn promotes condylar cartilage growth.
Persistent Identifierhttp://hdl.handle.net/10722/66248
ISSN
2015 Impact Factor: 2.484
2015 SCImago Journal Rankings: 1.583
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, AFSen_HK
dc.contributor.authorYang, YQen_HK
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorHägg, EUOen_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2010-09-06T05:44:47Z-
dc.date.available2010-09-06T05:44:47Z-
dc.date.issued2006en_HK
dc.identifier.citationFrontiers In Bioscience, 2006, v. 11 n. 1 P.889-1198, p. 949-954en_HK
dc.identifier.issn1093-9946en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66248-
dc.description.abstractMechanical loading can influence the biological behavior of the bone-associated cells leading to adaptive changes in skeletal mass and architecture. SOX9 and PTHrP genes are known to regulate chondrocyte differentiation and delay maturation, ultimately control the endochondral bone formation. To investigate the effects of repeated mechanical loading on bone, 280 Sprague-Dawley rats were used in this experiment. The animals were randomly allocated into experimental and control groups. Repeated mechanical loading was applied through a bite-jumping device in the experimental group. The experimental animals were sacrificed on 10 different time points together with the matched control. Total RNA was extracted from the mandibular condylar cartilage for PTHrP and SOX9 genes quantification using real-time RT-PCR. Results showed that PTHrP expression was increased and reached a peak level on the seventh day after mechanical loading was given. Repeated mechanical loading triggered a significant increase of PTHrP expression leading to another peak increment. The expression of SOX9 was highly correlated with the PTHrP expression, and its pattern of expression was similar to that of PTHrP after repeated mechanical loading. In conclusions, repeated mechanical loading on the condyle triggers the expression of PTHrP and SOX9, which in turn promotes condylar cartilage growth.en_HK
dc.languageengen_HK
dc.publisherFrontiers in Bioscience. The Journal's web site is located at http://www.frontbiosci.org/en_HK
dc.relation.ispartofFrontiers in Bioscienceen_HK
dc.subjectCartilageen_HK
dc.subjectCondylesen_HK
dc.subjectMechanicalen_HK
dc.subjectPTHrPen_HK
dc.subjectRT-PCRen_HK
dc.subjectSOX9en_HK
dc.subjectStressen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBone and Bones - metabolismen_HK
dc.subject.meshCartilage - growth & development - metabolism - pathologyen_HK
dc.subject.meshCell Differentiationen_HK
dc.subject.meshCell Proliferationen_HK
dc.subject.meshChondrocytes - metabolismen_HK
dc.subject.meshDNA, Complementary - metabolismen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Expression Regulationen_HK
dc.subject.meshHigh Mobility Group Proteins - metabolismen_HK
dc.subject.meshMandibular Condyle - growth & development - metabolism - pathologyen_HK
dc.subject.meshModels, Biologicalen_HK
dc.subject.meshModels, Statisticalen_HK
dc.subject.meshParathyroid Hormone-Related Protein - metabolismen_HK
dc.subject.meshPhenotypeen_HK
dc.subject.meshRNA - metabolismen_HK
dc.subject.meshRNA, Messenger - metabolismen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshSOX9 Transcription Factoren_HK
dc.subject.meshStress, Mechanicalen_HK
dc.subject.meshTemperatureen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshTranscription Factors - metabolismen_HK
dc.titleFactors regulating condylar cartilage growth under repeated load applicationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1093-9946&volume=11&spage=949&epage=954&date=2006&atitle=Factors+regulating+condylar+cartilage+growth+under+repeated+load+applicationen_HK
dc.identifier.emailYang, YQ: yangyanq@hkucc.hku.hken_HK
dc.identifier.emailWong, RWK: fyoung@hku.hken_HK
dc.identifier.emailHägg, EUO: euohagg@hkusua.hku.hken_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityYang, YQ=rp00045en_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.identifier.authorityHägg, EUO=rp00020en_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2741/1851en_HK
dc.identifier.pmid16146785-
dc.identifier.scopuseid_2-s2.0-32844455272en_HK
dc.identifier.hkuros113404en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-32844455272&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue1 P.889-1198en_HK
dc.identifier.spage949en_HK
dc.identifier.epage954en_HK
dc.identifier.isiWOS:000232528000077-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNg, AFS=34974512600en_HK
dc.identifier.scopusauthoridYang, YQ=36623085300en_HK
dc.identifier.scopusauthoridWong, RWK=7402127170en_HK
dc.identifier.scopusauthoridHägg, EUO=7006790279en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK

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