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Article: In vitro post-antifungal effect (PAFE) elicited by chlorhexidine gluconate on oral isolates of Candida albicans

TitleIn vitro post-antifungal effect (PAFE) elicited by chlorhexidine gluconate on oral isolates of Candida albicans
Authors
KeywordsCandida albicans
Chlorhexidine gluconate
Post-antifungal effect
Issue Date1999
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/0891060x.asp
Citation
Microbial Ecology In Health And Disease, 1999, v. 11 n. 3, p. 143-148 How to Cite?
AbstractThe post-antifungal effect (PAFE) is defined as the suppression of growth that persists following brief exposure of yeasts and other fungi to antimycotics and subsequent removal of the drug. There is no data available on the PAFE of chlorhexidine gluconate on oral isolates of Candida albicans. As chlorhexidine gluconate is by far the commonest antiseptic mouth wash prescribed in dentistry, the main aim of this investigation was to measure the PAFE of 10 oral isolates of C, albicans following limited exposure (30 min) to sub-therapeutic concentrations of this antiseptic. The PAFE was determined as the difference in time (h) required for the growth of the drug- free control and the drug-exposed test cultures to increase to 0.05 absorbance level at 520 nm following removal of the antifungal agent. The mean duration of PAFE elicited by 0.005, 0.0025 and 0.00125% chlorhexidine gluconate was 9.91(± 1.43) h, 1.65 (± 0.21) h and 0.67 (± 0.12) h, respectively. These findings, reported here for the first time, indicate that even a brief exposure to sub-therapeutic and sub-lethal levels of chlorhexidine gluconate may suppress the growth of oral C. albicans isolates, thereby minimising the pathogenic potential of this opportunistic fungus.
Persistent Identifierhttp://hdl.handle.net/10722/66226
ISSN
1998 Impact Factor: 0.605
2012 SCImago Journal Rankings: 0.281
References

 

DC FieldValueLanguage
dc.contributor.authorEllepola, ANBen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.date.accessioned2010-09-06T05:44:37Z-
dc.date.available2010-09-06T05:44:37Z-
dc.date.issued1999en_HK
dc.identifier.citationMicrobial Ecology In Health And Disease, 1999, v. 11 n. 3, p. 143-148en_HK
dc.identifier.issn0891-060Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/66226-
dc.description.abstractThe post-antifungal effect (PAFE) is defined as the suppression of growth that persists following brief exposure of yeasts and other fungi to antimycotics and subsequent removal of the drug. There is no data available on the PAFE of chlorhexidine gluconate on oral isolates of Candida albicans. As chlorhexidine gluconate is by far the commonest antiseptic mouth wash prescribed in dentistry, the main aim of this investigation was to measure the PAFE of 10 oral isolates of C, albicans following limited exposure (30 min) to sub-therapeutic concentrations of this antiseptic. The PAFE was determined as the difference in time (h) required for the growth of the drug- free control and the drug-exposed test cultures to increase to 0.05 absorbance level at 520 nm following removal of the antifungal agent. The mean duration of PAFE elicited by 0.005, 0.0025 and 0.00125% chlorhexidine gluconate was 9.91(± 1.43) h, 1.65 (± 0.21) h and 0.67 (± 0.12) h, respectively. These findings, reported here for the first time, indicate that even a brief exposure to sub-therapeutic and sub-lethal levels of chlorhexidine gluconate may suppress the growth of oral C. albicans isolates, thereby minimising the pathogenic potential of this opportunistic fungus.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/0891060x.aspen_HK
dc.relation.ispartofMicrobial Ecology in Health and Diseaseen_HK
dc.rightsMicrobial Ecology in Health & Disease. Copyright © Informa Healthcare.en_HK
dc.subjectCandida albicansen_HK
dc.subjectChlorhexidine gluconateen_HK
dc.subjectPost-antifungal effecten_HK
dc.titleIn vitro post-antifungal effect (PAFE) elicited by chlorhexidine gluconate on oral isolates of Candida albicansen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0891-060X&volume=11&spage=143&epage=148&date=1999&atitle=In+vitro+post-antifungal+effect+(PAFE)+elicited+by+chlorhexidine+gluconate+on+oral+isolates+of+Candida+albicansen_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-0032711355en_HK
dc.identifier.hkuros47544en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032711355&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue3en_HK
dc.identifier.spage143en_HK
dc.identifier.epage148en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridEllepola, ANB=6604060863en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK

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