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Article: Early healing pattern of statin-induced osteogenesis

TitleEarly healing pattern of statin-induced osteogenesis
Authors
KeywordsBone graft
Bone induction
Collagen
Statin
Issue Date2005
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/bjom
Citation
British Journal Of Oral And Maxillofacial Surgery, 2005, v. 43 n. 1, p. 46-50 How to Cite?
AbstractWe examined the early histological expressions of vascular endothelial growth factor (VEGF), bone morphogenetic protein (BMP)-2 and core binding factor (Cbfa1) in healing bones with and without a statin (simvastatin). Thirty bone defects were created in the parietal bones of 15 New Zealand white rabbits. In the statin group (n = 9), the defects were grafted with carriers of collagen matrix mixed with simvastatin solution, and the animals were killed on days 1 (n = 1), 2 (n = 1), 3 (n = 2), 4 (n = 2), 5 (n = 2) and 6 (n = 1) after operation. In the collagen matrix group, the defects were grafted with carriers of collagen matrix mixed with water for injection, and killed on days 1-6 postoperatively. Immunolocalisation studies of the defects grafted with statin showed that VEGF was expressed on day 3 postoperatively, BMP-2 on day 4, Cbfa1 on day 5 and that new bone was formed by day 5. These events occurred one day earlier than in the group grafted with the carrier alone. The statin induced and accelerated formation of bone locally, and triggered the early expression of growth factors that regulate angiogenesis, differentiation of bone cells, and osteogenesis. © 2004 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/66214
ISSN
2015 Impact Factor: 1.237
2015 SCImago Journal Rankings: 0.887
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2010-09-06T05:44:31Z-
dc.date.available2010-09-06T05:44:31Z-
dc.date.issued2005en_HK
dc.identifier.citationBritish Journal Of Oral And Maxillofacial Surgery, 2005, v. 43 n. 1, p. 46-50en_HK
dc.identifier.issn0266-4356en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66214-
dc.description.abstractWe examined the early histological expressions of vascular endothelial growth factor (VEGF), bone morphogenetic protein (BMP)-2 and core binding factor (Cbfa1) in healing bones with and without a statin (simvastatin). Thirty bone defects were created in the parietal bones of 15 New Zealand white rabbits. In the statin group (n = 9), the defects were grafted with carriers of collagen matrix mixed with simvastatin solution, and the animals were killed on days 1 (n = 1), 2 (n = 1), 3 (n = 2), 4 (n = 2), 5 (n = 2) and 6 (n = 1) after operation. In the collagen matrix group, the defects were grafted with carriers of collagen matrix mixed with water for injection, and killed on days 1-6 postoperatively. Immunolocalisation studies of the defects grafted with statin showed that VEGF was expressed on day 3 postoperatively, BMP-2 on day 4, Cbfa1 on day 5 and that new bone was formed by day 5. These events occurred one day earlier than in the group grafted with the carrier alone. The statin induced and accelerated formation of bone locally, and triggered the early expression of growth factors that regulate angiogenesis, differentiation of bone cells, and osteogenesis. © 2004 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/bjomen_HK
dc.relation.ispartofBritish Journal of Oral and Maxillofacial Surgeryen_HK
dc.subjectBone graften_HK
dc.subjectBone inductionen_HK
dc.subjectCollagenen_HK
dc.subjectStatinen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBone Morphogenetic Protein 2en_HK
dc.subject.meshBone Morphogenetic Proteins - biosynthesisen_HK
dc.subject.meshBone and Bones - metabolismen_HK
dc.subject.meshCollagenen_HK
dc.subject.meshCore Binding Factor alpha Subunitsen_HK
dc.subject.meshDNA-Binding Proteins - biosynthesisen_HK
dc.subject.meshHydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacologyen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshOsteogenesis - drug effectsen_HK
dc.subject.meshPharmaceutical Vehiclesen_HK
dc.subject.meshRabbitsen_HK
dc.subject.meshSimvastatin - pharmacologyen_HK
dc.subject.meshSkull - surgeryen_HK
dc.subject.meshTranscription Factors - biosynthesisen_HK
dc.subject.meshTransforming Growth Factor beta - biosynthesisen_HK
dc.subject.meshVascular Endothelial Growth Factor A - biosynthesisen_HK
dc.subject.meshWound Healing - drug effectsen_HK
dc.titleEarly healing pattern of statin-induced osteogenesisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0266-4356&volume=43&spage=46&epage=50&date=2005&atitle=Early+healing+pattern+of+statin-induced+osteogenesis+en_HK
dc.identifier.emailWong, RWK: fyoung@hku.hken_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bjoms.2004.08.014en_HK
dc.identifier.pmid15620774-
dc.identifier.scopuseid_2-s2.0-11844306556en_HK
dc.identifier.hkuros113402en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-11844306556&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume43en_HK
dc.identifier.issue1en_HK
dc.identifier.spage46en_HK
dc.identifier.epage50en_HK
dc.identifier.isiWOS:000226421600009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, RWK=7402127170en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK

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