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Article: Expression of tissue inhibitor of metalloproteinase during early stages of bone graft healing

TitleExpression of tissue inhibitor of metalloproteinase during early stages of bone graft healing
Authors
KeywordsBone grafts
MMP
TIMP
Tissue inhibitor of metalloproteinase
Issue Date2006
PublisherFrontiers in Bioscience. The Journal's web site is located at http://www.frontbiosci.org/
Citation
Frontiers In Bioscience, 2006, v. 11 n. 2 P.1591-2006, p. 1861-1869 How to Cite?
AbstractThe aim of this study was to investigate the temporal expression of TIMP-1 within endochondral and intramembranous bone grafts during the early stages of healing in thirty six adult New Zealand white rabbits. Total RNA was isolated from bone grafts extracted on days 0-11 and day 14 post-grafting, for RT-PCR analysis. In situ hybridization was carried out on days 1-9 and day 14. Results showed TIMP-1 expression coincides with osteogenesis, which indicates a role for TIMP in preserving the newly formed bone during the initial stages of graft healing. Bone grafts play an important role in influencing the healing process mediated by the host tissues. The temporal expression of TIMP-1 differs in endochondral and intramembranous bone grafts. The earlier expression of TIMP-1 by endochondral bone grafts, could be the reason for the delayed vascularization while the expression of TIMP-1 by the intramembranous bone grafts, at a later stage could allow for earlier vascularization.
Persistent Identifierhttp://hdl.handle.net/10722/66200
ISSN
2015 Impact Factor: 2.484
2015 SCImago Journal Rankings: 1.583
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTwitty, Aen_HK
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorShum, DKYen_HK
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorCheung, LKen_HK
dc.date.accessioned2010-09-06T05:44:24Z-
dc.date.available2010-09-06T05:44:24Z-
dc.date.issued2006en_HK
dc.identifier.citationFrontiers In Bioscience, 2006, v. 11 n. 2 P.1591-2006, p. 1861-1869en_HK
dc.identifier.issn1093-9946en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66200-
dc.description.abstractThe aim of this study was to investigate the temporal expression of TIMP-1 within endochondral and intramembranous bone grafts during the early stages of healing in thirty six adult New Zealand white rabbits. Total RNA was isolated from bone grafts extracted on days 0-11 and day 14 post-grafting, for RT-PCR analysis. In situ hybridization was carried out on days 1-9 and day 14. Results showed TIMP-1 expression coincides with osteogenesis, which indicates a role for TIMP in preserving the newly formed bone during the initial stages of graft healing. Bone grafts play an important role in influencing the healing process mediated by the host tissues. The temporal expression of TIMP-1 differs in endochondral and intramembranous bone grafts. The earlier expression of TIMP-1 by endochondral bone grafts, could be the reason for the delayed vascularization while the expression of TIMP-1 by the intramembranous bone grafts, at a later stage could allow for earlier vascularization.en_HK
dc.languageengen_HK
dc.publisherFrontiers in Bioscience. The Journal's web site is located at http://www.frontbiosci.org/en_HK
dc.relation.ispartofFrontiers in Bioscienceen_HK
dc.subjectBone graftsen_HK
dc.subjectMMPen_HK
dc.subjectTIMPen_HK
dc.subjectTissue inhibitor of metalloproteinaseen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBone Matrixen_HK
dc.subject.meshBone Transplantationen_HK
dc.subject.meshBone and Bones - metabolismen_HK
dc.subject.meshGene Expressionen_HK
dc.subject.meshIn Situ Hybridizationen_HK
dc.subject.meshMatrix Metalloproteinases - metabolismen_HK
dc.subject.meshOsteogenesisen_HK
dc.subject.meshRNA - metabolismen_HK
dc.subject.meshRNA, Messenger - metabolismen_HK
dc.subject.meshRabbitsen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshTissue Inhibitor of Metalloproteinase-1 - metabolismen_HK
dc.subject.meshTissue Inhibitor of Metalloproteinases - biosynthesis - metabolism - physiologyen_HK
dc.subject.meshTransplantsen_HK
dc.subject.meshWound Healingen_HK
dc.titleExpression of tissue inhibitor of metalloproteinase during early stages of bone graft healingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1093-9946&volume=11&spage=1861&epage=1869&date=2006&atitle=Expression+of+tissue+inhibitor+of+metalloproteinase+during+early+stages+of+bone+graft+healingen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_HK
dc.identifier.emailWong, RWK: fyoung@hku.hken_HK
dc.identifier.emailCheung, LK: lkcheung@hkucc.hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.identifier.authorityShum, DKY=rp00321en_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.identifier.authorityCheung, LK=rp00013en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2741/1929-
dc.identifier.pmid16368562-
dc.identifier.scopuseid_2-s2.0-32844460618en_HK
dc.identifier.hkuros110635en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-32844460618&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue2 P.1591-2006en_HK
dc.identifier.spage1861en_HK
dc.identifier.epage1869en_HK
dc.identifier.isiWOS:000234180200057-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTwitty, A=12345207900en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridShum, DKY=7004824447en_HK
dc.identifier.scopusauthoridWong, RWK=7402127170en_HK
dc.identifier.scopusauthoridCheung, LK=7102302747en_HK

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