Article: Factors affecting the adherence of Candida albicans to human buccal epithelial cells in human immunodeficiency virus infection

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TitleFactors affecting the adherence of Candida albicans to human buccal epithelial cells in human immunodeficiency virus infection
AuthorsTsang, CSP1
Samaranayake, LP1
Issue Date1999
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJD
CitationBritish Journal Of Dermatology, 1999, v. 141 n. 5, p. 852-858 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1365-2133.1999.03158.x
AbstractAdherence to host surfaces is an essential prerequisite for colonization and infection. We compared the adherence of 15 oral isolates of Candida albicans harvested from human immunodeficiency virus (HIV)-infected individuals and 12 isolates from HIV-free individuals to buccal epithelial cells (BECs) from HIV-free individuals, and the adherence of a reference strain of C. albicans to BECs from HIV-infected as well as HIV-free individuals. C. albicans from HIV-infected individuals showed adherence values similar to those from HIV-free individuals. The clinical and laboratory parameters of the subjects from whom the Candida were isolated did not correlate with adherence. A reference strain of C. albicans (GDH 1957), however, adhered more readily to BECs from HIV-infected individuals than to cells from an HIV-free cohort. Several variables were found to be associated with the adherence of C. albicans to BECs from HIV-infected individuals: use of zidovudine, antibacterials and antiparasitics was associated with increased adhesion, while haemophilia, heterosexuality, bisexuality, increased age, decreased CD4 + count and use of folate were associated with a decreased candidal adhesion (all P < 0.05). Our data suggest that the quality of BECs including their receptivity to Candida may play an important part in increasing the oral yeast carriage in HIV infection.
ISSN0007-0963
2011 Impact Factor: 3.666
2011 SCImago Journal Rankings: 0.342
DOIhttp://dx.doi.org/10.1046/j.1365-2133.1999.03158.x
ISI Accession Number IDWOS:000084218100012
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorTsang, CSP
dc.contributor.authorSamaranayake, LP
dc.date.accessioned2010-09-06T05:44:21Z
dc.date.available2010-09-06T05:44:21Z
dc.date.issued1999
dc.description.abstractAdherence to host surfaces is an essential prerequisite for colonization and infection. We compared the adherence of 15 oral isolates of Candida albicans harvested from human immunodeficiency virus (HIV)-infected individuals and 12 isolates from HIV-free individuals to buccal epithelial cells (BECs) from HIV-free individuals, and the adherence of a reference strain of C. albicans to BECs from HIV-infected as well as HIV-free individuals. C. albicans from HIV-infected individuals showed adherence values similar to those from HIV-free individuals. The clinical and laboratory parameters of the subjects from whom the Candida were isolated did not correlate with adherence. A reference strain of C. albicans (GDH 1957), however, adhered more readily to BECs from HIV-infected individuals than to cells from an HIV-free cohort. Several variables were found to be associated with the adherence of C. albicans to BECs from HIV-infected individuals: use of zidovudine, antibacterials and antiparasitics was associated with increased adhesion, while haemophilia, heterosexuality, bisexuality, increased age, decreased CD4 + count and use of folate were associated with a decreased candidal adhesion (all P < 0.05). Our data suggest that the quality of BECs including their receptivity to Candida may play an important part in increasing the oral yeast carriage in HIV infection.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationBritish Journal Of Dermatology, 1999, v. 141 n. 5, p. 852-858 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1365-2133.1999.03158.x
dc.identifier.doihttp://dx.doi.org/10.1046/j.1365-2133.1999.03158.x
dc.identifier.epage858
dc.identifier.hkuros47543
dc.identifier.isiWOS:000084218100012
dc.identifier.issn0007-0963
2011 Impact Factor: 3.666
2011 SCImago Journal Rankings: 0.342
dc.identifier.issue5
dc.identifier.openurl
dc.identifier.pmid10583166
dc.identifier.scopuseid_2-s2.0-0032760172
dc.identifier.spage852
dc.identifier.urihttp://hdl.handle.net/10722/66194
dc.identifier.volume141
dc.languageeng
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJD
dc.publisher.placeUnited Kingdom
dc.relation.ispartofBritish Journal of Dermatology
dc.relation.referencesReferences in Scopus
dc.rightsBritish Journal of Dermatology. Copyright © Blackwell Publishing Ltd.
dc.subject.meshAIDS-Related Opportunistic Infections - microbiology
dc.subject.meshAdult
dc.subject.meshCandida albicans - physiology
dc.subject.meshCandidiasis, Oral - microbiology
dc.subject.meshCell Adhesion
dc.subject.meshCell Culture Techniques
dc.subject.meshEpithelial Cells - microbiology
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLogistic Models
dc.subject.meshMale
dc.subject.meshMouth Mucosa - microbiology
dc.titleFactors affecting the adherence of Candida albicans to human buccal epithelial cells in human immunodeficiency virus infection
dc.typeArticle
Author Affiliations
  1. Prince Philip Dental Hospital