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Article: Factors affecting the adherence of Candida albicans to human buccal epithelial cells in human immunodeficiency virus infection
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TitleFactors affecting the adherence of Candida albicans to human buccal epithelial cells in human immunodeficiency virus infection
 
AuthorsTsang, CSP1
Samaranayake, LP1
 
Issue Date1999
 
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJD
 
CitationBritish Journal Of Dermatology, 1999, v. 141 n. 5, p. 852-858 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1365-2133.1999.03158.x
 
AbstractAdherence to host surfaces is an essential prerequisite for colonization and infection. We compared the adherence of 15 oral isolates of Candida albicans harvested from human immunodeficiency virus (HIV)-infected individuals and 12 isolates from HIV-free individuals to buccal epithelial cells (BECs) from HIV-free individuals, and the adherence of a reference strain of C. albicans to BECs from HIV-infected as well as HIV-free individuals. C. albicans from HIV-infected individuals showed adherence values similar to those from HIV-free individuals. The clinical and laboratory parameters of the subjects from whom the Candida were isolated did not correlate with adherence. A reference strain of C. albicans (GDH 1957), however, adhered more readily to BECs from HIV-infected individuals than to cells from an HIV-free cohort. Several variables were found to be associated with the adherence of C. albicans to BECs from HIV-infected individuals: use of zidovudine, antibacterials and antiparasitics was associated with increased adhesion, while haemophilia, heterosexuality, bisexuality, increased age, decreased CD4 + count and use of folate were associated with a decreased candidal adhesion (all P < 0.05). Our data suggest that the quality of BECs including their receptivity to Candida may play an important part in increasing the oral yeast carriage in HIV infection.
 
ISSN0007-0963
2012 Impact Factor: 3.759
2012 SCImago Journal Rankings: 1.736
 
DOIhttp://dx.doi.org/10.1046/j.1365-2133.1999.03158.x
 
ISI Accession Number IDWOS:000084218100012
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTsang, CSP
 
dc.contributor.authorSamaranayake, LP
 
dc.date.accessioned2010-09-06T05:44:21Z
 
dc.date.available2010-09-06T05:44:21Z
 
dc.date.issued1999
 
dc.description.abstractAdherence to host surfaces is an essential prerequisite for colonization and infection. We compared the adherence of 15 oral isolates of Candida albicans harvested from human immunodeficiency virus (HIV)-infected individuals and 12 isolates from HIV-free individuals to buccal epithelial cells (BECs) from HIV-free individuals, and the adherence of a reference strain of C. albicans to BECs from HIV-infected as well as HIV-free individuals. C. albicans from HIV-infected individuals showed adherence values similar to those from HIV-free individuals. The clinical and laboratory parameters of the subjects from whom the Candida were isolated did not correlate with adherence. A reference strain of C. albicans (GDH 1957), however, adhered more readily to BECs from HIV-infected individuals than to cells from an HIV-free cohort. Several variables were found to be associated with the adherence of C. albicans to BECs from HIV-infected individuals: use of zidovudine, antibacterials and antiparasitics was associated with increased adhesion, while haemophilia, heterosexuality, bisexuality, increased age, decreased CD4 + count and use of folate were associated with a decreased candidal adhesion (all P < 0.05). Our data suggest that the quality of BECs including their receptivity to Candida may play an important part in increasing the oral yeast carriage in HIV infection.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationBritish Journal Of Dermatology, 1999, v. 141 n. 5, p. 852-858 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1365-2133.1999.03158.x
 
dc.identifier.doihttp://dx.doi.org/10.1046/j.1365-2133.1999.03158.x
 
dc.identifier.epage858
 
dc.identifier.hkuros47543
 
dc.identifier.isiWOS:000084218100012
 
dc.identifier.issn0007-0963
2012 Impact Factor: 3.759
2012 SCImago Journal Rankings: 1.736
 
dc.identifier.issue5
 
dc.identifier.openurl
 
dc.identifier.pmid10583166
 
dc.identifier.scopuseid_2-s2.0-0032760172
 
dc.identifier.spage852
 
dc.identifier.urihttp://hdl.handle.net/10722/66194
 
dc.identifier.volume141
 
dc.languageeng
 
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJD
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofBritish Journal of Dermatology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsBritish Journal of Dermatology. Copyright © Blackwell Publishing Ltd.
 
dc.subject.meshAIDS-Related Opportunistic Infections - microbiology
 
dc.subject.meshAdult
 
dc.subject.meshCandida albicans - physiology
 
dc.subject.meshCandidiasis, Oral - microbiology
 
dc.subject.meshCell Adhesion
 
dc.subject.meshCell Culture Techniques
 
dc.subject.meshEpithelial Cells - microbiology
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshLogistic Models
 
dc.subject.meshMale
 
dc.subject.meshMouth Mucosa - microbiology
 
dc.titleFactors affecting the adherence of Candida albicans to human buccal epithelial cells in human immunodeficiency virus infection
 
dc.typeArticle
 
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Author Affiliations
  1. Prince Philip Dental Hospital