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Article: Mechanical strain leads to condylar growth in adult rats

TitleMechanical strain leads to condylar growth in adult rats
Authors
KeywordsAdult
Condylar growth
Mechanical strain
Mesenchymal cell
SOX9
Issue Date2005
PublisherFrontiers in Bioscience. The Journal's web site is located at http://www.frontbiosci.org/
Citation
Frontiers In Bioscience, 2005, v. 10 n. 1, p. 65-73 How to Cite?
AbstractMechanical strain produced by forward mandibular positioning was found to enhance mandibular condylar growth in experimental animals and in patients. This study was designed to identify the changes in number and rate of the proliferating mesenchymal cells in mandibular condyles of adult rats and to correlate these changes to the expression of SOX9 and type II collagen under mechanical strain. Seventy-eight 120-day-old female Sprague-Dawley rats were randomly allotted to six groups, nine animals in each experimental group according to different time points. Cell kinetic studies for expression of PCNA were used to identify number and rate of proliferating mesenchymal cells. Immunostaining of SOX9 and in situ hybridization of Col2a1 gene were carried out. Results showed a significant increase in number of replicating mesenchymal cells and proliferation rate. The expression of SOX9 was enhanced and Col2a1 gene transcript was then activated. The proliferative layer became thicker on experimental day 21. The thickness of chondroblast layer and chondrocyte layer showed significant increase from experimental day 14 to day 30. In conclusion, mechanical strain produced by mandibular advancement in adult rats promotes the proliferation of mesenchymal cells. Under control of transcription factor SOX9, these mesenchymal cells are then committed to enter the chondrogenic route leading to condylar growth.
Persistent Identifierhttp://hdl.handle.net/10722/66192
ISSN
2015 Impact Factor: 2.484
2015 SCImago Journal Rankings: 1.583
References

 

DC FieldValueLanguage
dc.contributor.authorXiong, Hen_HK
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorHagg, Uen_HK
dc.date.accessioned2010-09-06T05:44:20Z-
dc.date.available2010-09-06T05:44:20Z-
dc.date.issued2005en_HK
dc.identifier.citationFrontiers In Bioscience, 2005, v. 10 n. 1, p. 65-73en_HK
dc.identifier.issn1093-9946en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66192-
dc.description.abstractMechanical strain produced by forward mandibular positioning was found to enhance mandibular condylar growth in experimental animals and in patients. This study was designed to identify the changes in number and rate of the proliferating mesenchymal cells in mandibular condyles of adult rats and to correlate these changes to the expression of SOX9 and type II collagen under mechanical strain. Seventy-eight 120-day-old female Sprague-Dawley rats were randomly allotted to six groups, nine animals in each experimental group according to different time points. Cell kinetic studies for expression of PCNA were used to identify number and rate of proliferating mesenchymal cells. Immunostaining of SOX9 and in situ hybridization of Col2a1 gene were carried out. Results showed a significant increase in number of replicating mesenchymal cells and proliferation rate. The expression of SOX9 was enhanced and Col2a1 gene transcript was then activated. The proliferative layer became thicker on experimental day 21. The thickness of chondroblast layer and chondrocyte layer showed significant increase from experimental day 14 to day 30. In conclusion, mechanical strain produced by mandibular advancement in adult rats promotes the proliferation of mesenchymal cells. Under control of transcription factor SOX9, these mesenchymal cells are then committed to enter the chondrogenic route leading to condylar growth.en_HK
dc.languageengen_HK
dc.publisherFrontiers in Bioscience. The Journal's web site is located at http://www.frontbiosci.org/en_HK
dc.relation.ispartofFrontiers in Bioscienceen_HK
dc.subjectAdulten_HK
dc.subjectCondylar growthen_HK
dc.subjectMechanical strainen_HK
dc.subjectMesenchymal cellen_HK
dc.subjectSOX9en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Proliferationen_HK
dc.subject.meshChondrocytes - metabolismen_HK
dc.subject.meshCollagen - biosynthesisen_HK
dc.subject.meshCollagen Type II - biosynthesisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHigh Mobility Group Proteins - metabolismen_HK
dc.subject.meshKineticsen_HK
dc.subject.meshMandibular Condyle - growth & developmenten_HK
dc.subject.meshMesoderm - metabolismen_HK
dc.subject.meshModels, Biologicalen_HK
dc.subject.meshProliferating Cell Nuclear Antigen - biosynthesisen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshSOX9 Transcription Factoren_HK
dc.subject.meshStress, Mechanicalen_HK
dc.subject.meshTranscription Factors - metabolismen_HK
dc.titleMechanical strain leads to condylar growth in adult ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1093-9946&volume=10&spage=65&epage=73&date=2005&atitle=Mechanical+strain+leads+to+condylar+growth+in+adult+ratsen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.emailHagg, U: euohagg@hkusua.hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.identifier.authorityHagg, U=rp00020en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid15574348-
dc.identifier.scopuseid_2-s2.0-17444430003en_HK
dc.identifier.hkuros98727en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17444430003&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume10en_HK
dc.identifier.issue1en_HK
dc.identifier.spage65en_HK
dc.identifier.epage73en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridXiong, H=36852325600en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridHagg, U=7006790279en_HK

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