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Article: Experimentally induced unilateral tooth loss: Expression of type II collagen in temporomandibular joint cartilage

TitleExperimentally induced unilateral tooth loss: Expression of type II collagen in temporomandibular joint cartilage
Authors
Issue Date2003
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/joms
Citation
Journal Of Oral And Maxillofacial Surgery, 2003, v. 61 n. 9, p. 1054-1060 How to Cite?
AbstractPurpose: We sought to examine possible changes in pattern and concentration of type II collagen in the condylar cartilage and articular disc of the temporomandibular joint (TMJ) in response to unilateral extraction of mandibular teeth in a rabbit model as a means of elucidating the effects of unilateral mastication on the TMJ. Methods: A total of 12 experimental rabbits were killed either 3 or 6 weeks after the extractions, and 3 additional rabbits without extractions were used as controls. TMJ blocks from both sides of each of the 15 animals were examined for type II collagen via an immunoperoxidase procedure. Results: Anti-type II collagen antibody, (Ab) binding was detected mainly in the hypertrophic chondroblast layer of the condylar cartilage of normal rabbits. At 3 weeks after unilateral extraction of teeth, anti-type II collagen Ab binding to the territorial matrix of the hypertrophic chondroblast layer of the condylar cartilage and to the disc was stronger than normal. The increase in Ab binding appeared more dramatic on the nonfunctional side than on the functional side of TMJ. Variations from the normal pattern of anti-type II collagen Ab binding in terms of distribution through the extracellular matrix and fibrillar appearance were also observed. Conclusion: The findings suggest that the condylar cartilage and disc adapt to the imbalance induced by unilateral extraction of teeth through chondrocyte repair responses involving collagen II expression that appear to differ between the functional and nonfunctional sides of the TMJ. © 2003 American Association of Oral and Maxillofacial Surgeons.
Persistent Identifierhttp://hdl.handle.net/10722/66131
ISSN
2015 Impact Factor: 1.631
2015 SCImago Journal Rankings: 0.824
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHuang, Qen_HK
dc.contributor.authorOpstelten, Den_HK
dc.contributor.authorSamman, Nen_HK
dc.contributor.authorTideman, Hen_HK
dc.date.accessioned2010-09-06T05:43:50Z-
dc.date.available2010-09-06T05:43:50Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Oral And Maxillofacial Surgery, 2003, v. 61 n. 9, p. 1054-1060en_HK
dc.identifier.issn0278-2391en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66131-
dc.description.abstractPurpose: We sought to examine possible changes in pattern and concentration of type II collagen in the condylar cartilage and articular disc of the temporomandibular joint (TMJ) in response to unilateral extraction of mandibular teeth in a rabbit model as a means of elucidating the effects of unilateral mastication on the TMJ. Methods: A total of 12 experimental rabbits were killed either 3 or 6 weeks after the extractions, and 3 additional rabbits without extractions were used as controls. TMJ blocks from both sides of each of the 15 animals were examined for type II collagen via an immunoperoxidase procedure. Results: Anti-type II collagen antibody, (Ab) binding was detected mainly in the hypertrophic chondroblast layer of the condylar cartilage of normal rabbits. At 3 weeks after unilateral extraction of teeth, anti-type II collagen Ab binding to the territorial matrix of the hypertrophic chondroblast layer of the condylar cartilage and to the disc was stronger than normal. The increase in Ab binding appeared more dramatic on the nonfunctional side than on the functional side of TMJ. Variations from the normal pattern of anti-type II collagen Ab binding in terms of distribution through the extracellular matrix and fibrillar appearance were also observed. Conclusion: The findings suggest that the condylar cartilage and disc adapt to the imbalance induced by unilateral extraction of teeth through chondrocyte repair responses involving collagen II expression that appear to differ between the functional and nonfunctional sides of the TMJ. © 2003 American Association of Oral and Maxillofacial Surgeons.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jomsen_HK
dc.relation.ispartofJournal of Oral and Maxillofacial Surgeryen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAntibodiesen_HK
dc.subject.meshCartilage, Articular - metabolismen_HK
dc.subject.meshCollagen Type II - biosynthesisen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshExtracellular Matrix - metabolismen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshJaw, Edentulous, Partially - physiopathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMandible - physiopathologyen_HK
dc.subject.meshMandibular Condyle - metabolismen_HK
dc.subject.meshMasticationen_HK
dc.subject.meshProtein Bindingen_HK
dc.subject.meshRabbitsen_HK
dc.subject.meshStaining and Labelingen_HK
dc.subject.meshStatistics, Nonparametricen_HK
dc.subject.meshTemporomandibular Joint - metabolismen_HK
dc.subject.meshTooth Extractionen_HK
dc.subject.meshTooth Loss - physiopathologyen_HK
dc.titleExperimentally induced unilateral tooth loss: Expression of type II collagen in temporomandibular joint cartilageen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0278-2391&volume=61&issue=9&spage=1054&epage=1056&date=2003&atitle=Experimentally+induced+unilateral+tooth+loss:+expression+of+type+II+collagen+in+temporomandibular+joint+cartilageen_HK
dc.identifier.emailSamman, N:nsamman@hkucc.hku.hken_HK
dc.identifier.authoritySamman, N=rp00021en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0278-2391(03)00318-5en_HK
dc.identifier.pmid12966481-
dc.identifier.scopuseid_2-s2.0-0042861609en_HK
dc.identifier.hkuros80480en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0042861609&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume61en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1054en_HK
dc.identifier.epage1060en_HK
dc.identifier.isiWOS:000185046500012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHuang, Q=36050366700en_HK
dc.identifier.scopusauthoridOpstelten, D=16237067300en_HK
dc.identifier.scopusauthoridSamman, N=7006413627en_HK
dc.identifier.scopusauthoridTideman, H=7005602469en_HK

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