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Article: A quantitative assessment of the healing of intramembranous and endochondral autogenous bone grafts

TitleA quantitative assessment of the healing of intramembranous and endochondral autogenous bone grafts
Authors
Issue Date1999
PublisherOxford University Press. The Journal's web site is located at http://ejo.oxfordjournals.org/
Citation
European Journal Of Orthodontics, 1999, v. 21 n. 2, p. 119-126 How to Cite?
AbstractThe aim of the study was to assess quantitatively the amount of new bone formed in the early stages of healing of intramembranous and endochondral autogenous bone grafts so as to gain further insight into their integration with host bone. Eighteen critical size defects were created in the parietal bone of nine New Zealand White rabbits. In the experimental group (five rabbits), each rabbit was grafted with intramembranous bone in one defect and with endochondral bone in the other. In the control group (four rabbits), one defect was left empty (passive control) and the other was grafted with rabbit skin collagen (active control). After 14 days, the rabbits were killed and the defects were prepared for histological analysis. Serial sections were made across the whole defect. Each defect was divided into five regions spaced 1500 μm apart. Two sections were randomly drawn from each region. Quantitative analysis was performed on 100 sections using an image analyser computer software system to assess the amount of new bone formed in each defect. No bone was detected across the defect in either the active or passive controls. One-hundred-and-sixty-six per cent more new bone was formed in defects grafted with intramembranous bone than those grafted with endochondral bone. This represented an extremely significant difference (P < 0.0001, unpaired t-test) between the two groups. The results show that intramembranous autogenous bone produced more bone than the endochondral bone when grafted in the skull. Clinically, it is recommended that intramembranous bone is used to replace lost membranous bone in the oral cavity, as well as in skull defects, whenever possible.
Persistent Identifierhttp://hdl.handle.net/10722/66087
ISSN
2015 Impact Factor: 1.44
2015 SCImago Journal Rankings: 1.090
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2010-09-06T05:43:28Z-
dc.date.available2010-09-06T05:43:28Z-
dc.date.issued1999en_HK
dc.identifier.citationEuropean Journal Of Orthodontics, 1999, v. 21 n. 2, p. 119-126en_HK
dc.identifier.issn0141-5387en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66087-
dc.description.abstractThe aim of the study was to assess quantitatively the amount of new bone formed in the early stages of healing of intramembranous and endochondral autogenous bone grafts so as to gain further insight into their integration with host bone. Eighteen critical size defects were created in the parietal bone of nine New Zealand White rabbits. In the experimental group (five rabbits), each rabbit was grafted with intramembranous bone in one defect and with endochondral bone in the other. In the control group (four rabbits), one defect was left empty (passive control) and the other was grafted with rabbit skin collagen (active control). After 14 days, the rabbits were killed and the defects were prepared for histological analysis. Serial sections were made across the whole defect. Each defect was divided into five regions spaced 1500 μm apart. Two sections were randomly drawn from each region. Quantitative analysis was performed on 100 sections using an image analyser computer software system to assess the amount of new bone formed in each defect. No bone was detected across the defect in either the active or passive controls. One-hundred-and-sixty-six per cent more new bone was formed in defects grafted with intramembranous bone than those grafted with endochondral bone. This represented an extremely significant difference (P < 0.0001, unpaired t-test) between the two groups. The results show that intramembranous autogenous bone produced more bone than the endochondral bone when grafted in the skull. Clinically, it is recommended that intramembranous bone is used to replace lost membranous bone in the oral cavity, as well as in skull defects, whenever possible.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://ejo.oxfordjournals.org/en_HK
dc.relation.ispartofEuropean Journal of Orthodonticsen_HK
dc.rightsEuropean Journal of Orthodontics. Copyright © Oxford University Press.en_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBone Transplantation - classification - pathology - physiologyen_HK
dc.subject.meshCollagen - therapeutic useen_HK
dc.subject.meshColoring Agents - diagnostic useen_HK
dc.subject.meshConfidence Intervalsen_HK
dc.subject.meshConnective Tissue - pathologyen_HK
dc.subject.meshImage Processing, Computer-Assisteden_HK
dc.subject.meshOsteogenesis - physiologyen_HK
dc.subject.meshParietal Bone - pathology - surgeryen_HK
dc.subject.meshRabbitsen_HK
dc.subject.meshSoftwareen_HK
dc.subject.meshTransplantation, Autologousen_HK
dc.subject.meshWound Healing - physiologyen_HK
dc.titleA quantitative assessment of the healing of intramembranous and endochondral autogenous bone graftsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0141-5387&volume=21&spage=119 &epage= 126&date=1999&atitle=A+quantitative+assessment+of+the+healing+of+intramembranous+and+endochondral+autogenous+bone+graftsen_HK
dc.identifier.emailWong, RWK: fyoung@hku.hken_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/ejo/21.2.119en_HK
dc.identifier.pmid10327735-
dc.identifier.scopuseid_2-s2.0-0033109835en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033109835&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue2en_HK
dc.identifier.spage119en_HK
dc.identifier.epage126en_HK
dc.identifier.isiWOS:000080002400002-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, RWK=7402127170en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK

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