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Article: Fractional inhibitory concentration index of combinations of antibacterial agents against cariogenic organisms

TitleFractional inhibitory concentration index of combinations of antibacterial agents against cariogenic organisms
Authors
Issue Date2000
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jdent
Citation
Journal Of Dentistry, 2000, v. 28 n. 8, p. 565-570 How to Cite?
AbstractObjectives: To examine the inhibitory effects between paired combinations of four antibacterial agents that have been investigated in dentistry against six bacteria associated with dentinal caries. Methods: The antibacterial agents tested were: chlorhexidine dihydrochloride, benzalkonium chloride, cetrimide and cetylpyridinium chloride. Two organisms each belonging to Streptococcus, Lactobacillus and Actinomyces species were evaluated against these agents. A checkerboard microtitration method was used to determine the minimum inhibitory concentration and fractionary inhibitory concentration (FIC) and ∑FIC index of the paired combinations of antibacterial agents against the six species of bacteria. Appropriate controls were included. The ∑FIC index was then used to determine if synergy, antagonism, or indifference occurred as a result of interactions between the antibacterial agents and the test organisms. Results: The data from a total of 295 test results were evaluated. Using ∑FIC values for synergy as ≤0.5 and antagonism as >4.0 as recommended by The American Society for Microbiology, no significant synergistic or antagonistic interactions were observed between the paired antibacterial agents when tested against selected organisms. However, a tendency for an additive antibacterial effect was observed with approximately a third of the test results. Nonetheless, no combination of antibacterial agents appeared to be superior to any other. Conclusions: According to these in vitro results, there appears to be no beneficial effect of combining the antibacterial agents against the individual cariogenic micro-organisms selected. However, it may be beneficial to use combined antibacterial agents that have a broader range of activity against an ecosystem of bacteria than using individual agents. © 2000 Elsevier Science Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/66061
ISSN
2015 Impact Factor: 3.109
2015 SCImago Journal Rankings: 1.029
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBotelho, MGen_HK
dc.date.accessioned2010-09-06T05:43:16Z-
dc.date.available2010-09-06T05:43:16Z-
dc.date.issued2000en_HK
dc.identifier.citationJournal Of Dentistry, 2000, v. 28 n. 8, p. 565-570en_HK
dc.identifier.issn0300-5712en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66061-
dc.description.abstractObjectives: To examine the inhibitory effects between paired combinations of four antibacterial agents that have been investigated in dentistry against six bacteria associated with dentinal caries. Methods: The antibacterial agents tested were: chlorhexidine dihydrochloride, benzalkonium chloride, cetrimide and cetylpyridinium chloride. Two organisms each belonging to Streptococcus, Lactobacillus and Actinomyces species were evaluated against these agents. A checkerboard microtitration method was used to determine the minimum inhibitory concentration and fractionary inhibitory concentration (FIC) and ∑FIC index of the paired combinations of antibacterial agents against the six species of bacteria. Appropriate controls were included. The ∑FIC index was then used to determine if synergy, antagonism, or indifference occurred as a result of interactions between the antibacterial agents and the test organisms. Results: The data from a total of 295 test results were evaluated. Using ∑FIC values for synergy as ≤0.5 and antagonism as >4.0 as recommended by The American Society for Microbiology, no significant synergistic or antagonistic interactions were observed between the paired antibacterial agents when tested against selected organisms. However, a tendency for an additive antibacterial effect was observed with approximately a third of the test results. Nonetheless, no combination of antibacterial agents appeared to be superior to any other. Conclusions: According to these in vitro results, there appears to be no beneficial effect of combining the antibacterial agents against the individual cariogenic micro-organisms selected. However, it may be beneficial to use combined antibacterial agents that have a broader range of activity against an ecosystem of bacteria than using individual agents. © 2000 Elsevier Science Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jdenten_HK
dc.relation.ispartofJournal of Dentistryen_HK
dc.rightsJournal of Dentistry. Copyright © Elsevier Ltd.en_HK
dc.subject.meshActinomyces - drug effectsen_HK
dc.subject.meshAnti-Infective Agents, Local - administration & dosage - pharmacologyen_HK
dc.subject.meshBenzalkonium Compounds - administration & dosage - pharmacologyen_HK
dc.subject.meshCetrimonium Compounds - administration & dosage - pharmacologyen_HK
dc.subject.meshCetylpyridinium - administration & dosage - pharmacologyen_HK
dc.subject.meshChlorhexidine - administration & dosage - pharmacologyen_HK
dc.subject.meshDental Caries - microbiologyen_HK
dc.subject.meshDrug Combinationsen_HK
dc.subject.meshDrug Interactionsen_HK
dc.subject.meshLactobacillus acidophilus - drug effectsen_HK
dc.subject.meshLactobacillus casei - drug effectsen_HK
dc.subject.meshMicrobial Sensitivity Testsen_HK
dc.subject.meshStreptococcus mutans - drug effectsen_HK
dc.subject.meshStreptococcus sanguis - drug effectsen_HK
dc.titleFractional inhibitory concentration index of combinations of antibacterial agents against cariogenic organismsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-5712&volume=28&issue=8&spage=565&epage=70&date=2000&atitle=Fractional+inhibitory+concentration+index+of+combinations+of+antibacterial+agents+against+cariogenic+organisms.en_HK
dc.identifier.emailBotelho, MG:botelho@hkucc.hku.hken_HK
dc.identifier.authorityBotelho, MG=rp00033en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11082524-
dc.identifier.scopuseid_2-s2.0-0034330038en_HK
dc.identifier.hkuros57967en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034330038&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue8en_HK
dc.identifier.spage565en_HK
dc.identifier.epage570en_HK
dc.identifier.isiWOS:000165387500004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridBotelho, MG=7005751169en_HK

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