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Article: Expression of type X collagen and capillary endothelium in condylar cartilage during osteogenic transition - A comparison between adaptive remodelling and natural growth

TitleExpression of type X collagen and capillary endothelium in condylar cartilage during osteogenic transition - A comparison between adaptive remodelling and natural growth
Authors
Issue Date2006
PublisherOxford University Press. The Journal's web site is located at http://ejo.oxfordjournals.org/
Citation
European Journal Of Orthodontics, 2006, v. 28 n. 3, p. 210-216 How to Cite?
Abstract
Adaptive remodelling of the condylar cartilage in response to mandibular protrusion constitutes the rationale for bite-jumping appliances to solicit growth modification. By investigating the expression of type X collagen and capillary endothelium, this study was designed to evaluate the osteogenic transition of chondrogenesis during adaptive remodelling of condylar cartilage and compare it with that under natural condylar growth. One hundred female Sprague-Dawley rats, 35 days of age, were divided into five experimental groups (n = 15, fitted with bite-jumping appliances) where condylar adaptation was created by forward repositioning of the mandible, and five control groups (n = 5) where the condyles underwent natural growth. The animals were sacrificed at 3, 7, 14, 21 and 30 days and 7 μm serial sections of the condyles were processed for in situ hybridization and immunohistochemical analyses. The expression of type X collagen in the hypertrophic zone and capillary endothelium in the erosive zone of condylar cartilage were examined to evaluate osteogenic transition, a critical programme leading to endochondral ossification. The results showed that (1) The temporal pattern of the expression of type X collagen and capillary endothelium during condylar adaptation coincided with that during natural condylar growth. (2) The amount of the expression of these two factors during condylar adaptation was significantly higher than that during natural growth (P < 0.001). It is suggested that condylar adaptation in growing rats triggered by mandibular forward positioning enhances osteogenic transition which eventually results in increased bone formation. © The Author 2006. Published by Oxford University Press on behalf of the European Orthodontics Society. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/66050
ISSN
2013 Impact Factor: 1.390
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. Shanghai Jiaotong University
  3. University of Sydney
  4. Sichuan University
DC FieldValueLanguage
dc.contributor.authorShen, Gen_HK
dc.contributor.authorZhao, Zen_HK
dc.contributor.authorKaluarachchi, Ken_HK
dc.contributor.authorBakr Rabie, Aen_HK
dc.date.accessioned2010-09-06T05:43:10Z-
dc.date.available2010-09-06T05:43:10Z-
dc.date.issued2006en_HK
dc.identifier.citationEuropean Journal Of Orthodontics, 2006, v. 28 n. 3, p. 210-216en_HK
dc.identifier.issn0141-5387en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66050-
dc.description.abstractAdaptive remodelling of the condylar cartilage in response to mandibular protrusion constitutes the rationale for bite-jumping appliances to solicit growth modification. By investigating the expression of type X collagen and capillary endothelium, this study was designed to evaluate the osteogenic transition of chondrogenesis during adaptive remodelling of condylar cartilage and compare it with that under natural condylar growth. One hundred female Sprague-Dawley rats, 35 days of age, were divided into five experimental groups (n = 15, fitted with bite-jumping appliances) where condylar adaptation was created by forward repositioning of the mandible, and five control groups (n = 5) where the condyles underwent natural growth. The animals were sacrificed at 3, 7, 14, 21 and 30 days and 7 μm serial sections of the condyles were processed for in situ hybridization and immunohistochemical analyses. The expression of type X collagen in the hypertrophic zone and capillary endothelium in the erosive zone of condylar cartilage were examined to evaluate osteogenic transition, a critical programme leading to endochondral ossification. The results showed that (1) The temporal pattern of the expression of type X collagen and capillary endothelium during condylar adaptation coincided with that during natural condylar growth. (2) The amount of the expression of these two factors during condylar adaptation was significantly higher than that during natural growth (P < 0.001). It is suggested that condylar adaptation in growing rats triggered by mandibular forward positioning enhances osteogenic transition which eventually results in increased bone formation. © The Author 2006. Published by Oxford University Press on behalf of the European Orthodontics Society. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://ejo.oxfordjournals.org/en_HK
dc.relation.ispartofEuropean Journal of Orthodonticsen_HK
dc.rightsEuropean Journal of Orthodontics. Copyright © Oxford University Press.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBone Remodelingen_HK
dc.subject.meshCartilage - cytology - metabolismen_HK
dc.subject.meshCollagen Type X - metabolismen_HK
dc.subject.meshEndothelium, Vascular - cytology - metabolismen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshMandibular Condyle - cytology - metabolismen_HK
dc.subject.meshModels, Animalen_HK
dc.subject.meshOrthodontic Appliances, Functional - adverse effectsen_HK
dc.subject.meshOsteogenesisen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.titleExpression of type X collagen and capillary endothelium in condylar cartilage during osteogenic transition - A comparison between adaptive remodelling and natural growthen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0141-5387&volume=28&spage=210&epage=216&date=2006&atitle=Expression+of+type+X+collagen+and+capillary+endothelium+in+condylar+cartilage+during+osteogenic+transition+-+a+comparison+between+adaptive+remodelling+and+natural+growthen_HK
dc.identifier.emailBakr Rabie, A: rabie@hku.hken_HK
dc.identifier.authorityBakr Rabie, A=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/ejo/cji123en_HK
dc.identifier.pmid16679327en_HK
dc.identifier.scopuseid_2-s2.0-33745685436en_HK
dc.identifier.hkuros124246en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745685436&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue3en_HK
dc.identifier.spage210en_HK
dc.identifier.epage216en_HK
dc.identifier.isiWOS:000238544400003-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridShen, G=7401966958en_HK
dc.identifier.scopusauthoridZhao, Z=14066852000en_HK
dc.identifier.scopusauthoridKaluarachchi, K=36905056500en_HK
dc.identifier.scopusauthoridBakr Rabie, A=7007172734en_HK
dc.identifier.citeulike747413-

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