Article: Expression of type X collagen and capillary endothelium in condylar cartilage during osteogenic transition - A comparison between adaptive remodelling and natural growth

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TitleExpression of type X collagen and capillary endothelium in condylar cartilage during osteogenic transition - A comparison between adaptive remodelling and natural growth
AuthorsShen, G1 3
Zhao, Z4
Kaluarachchi, K2
Bakr Rabie, A2
Issue Date2006
PublisherOxford University Press. The Journal's web site is located at http://ejo.oxfordjournals.org/
CitationEuropean Journal Of Orthodontics, 2006, v. 28 n. 3, p. 210-216 [How to Cite?]
DOI: http://dx.doi.org/10.1093/ejo/cji123
AbstractAdaptive remodelling of the condylar cartilage in response to mandibular protrusion constitutes the rationale for bite-jumping appliances to solicit growth modification. By investigating the expression of type X collagen and capillary endothelium, this study was designed to evaluate the osteogenic transition of chondrogenesis during adaptive remodelling of condylar cartilage and compare it with that under natural condylar growth. One hundred female Sprague-Dawley rats, 35 days of age, were divided into five experimental groups (n = 15, fitted with bite-jumping appliances) where condylar adaptation was created by forward repositioning of the mandible, and five control groups (n = 5) where the condyles underwent natural growth. The animals were sacrificed at 3, 7, 14, 21 and 30 days and 7 μm serial sections of the condyles were processed for in situ hybridization and immunohistochemical analyses. The expression of type X collagen in the hypertrophic zone and capillary endothelium in the erosive zone of condylar cartilage were examined to evaluate osteogenic transition, a critical programme leading to endochondral ossification. The results showed that (1) The temporal pattern of the expression of type X collagen and capillary endothelium during condylar adaptation coincided with that during natural condylar growth. (2) The amount of the expression of these two factors during condylar adaptation was significantly higher than that during natural growth (P < 0.001). It is suggested that condylar adaptation in growing rats triggered by mandibular forward positioning enhances osteogenic transition which eventually results in increased bone formation. © The Author 2006. Published by Oxford University Press on behalf of the European Orthodontics Society. All rights reserved.
ISSN0141-5387
2011 Impact Factor: 0.893
2011 SCImago Journal Rankings: 0.048
DOIhttp://dx.doi.org/10.1093/ejo/cji123
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorShen, G
dc.contributor.authorZhao, Z
dc.contributor.authorKaluarachchi, K
dc.contributor.authorBakr Rabie, A
dc.date.accessioned2010-09-06T05:43:10Z
dc.date.available2010-09-06T05:43:10Z
dc.date.issued2006
dc.description.abstractAdaptive remodelling of the condylar cartilage in response to mandibular protrusion constitutes the rationale for bite-jumping appliances to solicit growth modification. By investigating the expression of type X collagen and capillary endothelium, this study was designed to evaluate the osteogenic transition of chondrogenesis during adaptive remodelling of condylar cartilage and compare it with that under natural condylar growth. One hundred female Sprague-Dawley rats, 35 days of age, were divided into five experimental groups (n = 15, fitted with bite-jumping appliances) where condylar adaptation was created by forward repositioning of the mandible, and five control groups (n = 5) where the condyles underwent natural growth. The animals were sacrificed at 3, 7, 14, 21 and 30 days and 7 μm serial sections of the condyles were processed for in situ hybridization and immunohistochemical analyses. The expression of type X collagen in the hypertrophic zone and capillary endothelium in the erosive zone of condylar cartilage were examined to evaluate osteogenic transition, a critical programme leading to endochondral ossification. The results showed that (1) The temporal pattern of the expression of type X collagen and capillary endothelium during condylar adaptation coincided with that during natural condylar growth. (2) The amount of the expression of these two factors during condylar adaptation was significantly higher than that during natural growth (P < 0.001). It is suggested that condylar adaptation in growing rats triggered by mandibular forward positioning enhances osteogenic transition which eventually results in increased bone formation. © The Author 2006. Published by Oxford University Press on behalf of the European Orthodontics Society. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationEuropean Journal Of Orthodontics, 2006, v. 28 n. 3, p. 210-216 [How to Cite?]
DOI: http://dx.doi.org/10.1093/ejo/cji123
dc.identifier.citeulike747413
dc.identifier.doihttp://dx.doi.org/10.1093/ejo/cji123
dc.identifier.epage216
dc.identifier.hkuros124246
dc.identifier.isiWOS:000238544400003
dc.identifier.issn0141-5387
2011 Impact Factor: 0.893
2011 SCImago Journal Rankings: 0.048
dc.identifier.issue3
dc.identifier.openurl
dc.identifier.pmid16679327
dc.identifier.scopuseid_2-s2.0-33745685436
dc.identifier.spage210
dc.identifier.urihttp://hdl.handle.net/10722/66050
dc.identifier.volume28
dc.languageeng
dc.publisherOxford University Press. The Journal's web site is located at http://ejo.oxfordjournals.org/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofEuropean Journal of Orthodontics
dc.relation.referencesReferences in Scopus
dc.rightsEuropean Journal of Orthodontics. Copyright © Oxford University Press.
dc.subject.meshAnimals
dc.subject.meshBone Remodeling
dc.subject.meshCartilage - cytology - metabolism
dc.subject.meshCollagen Type X - metabolism
dc.subject.meshEndothelium, Vascular - cytology - metabolism
dc.subject.meshFemale
dc.subject.meshMandibular Condyle - cytology - metabolism
dc.subject.meshModels, Animal
dc.subject.meshOrthodontic Appliances, Functional - adverse effects
dc.subject.meshOsteogenesis
dc.subject.meshRats
dc.subject.meshRats, Sprague-Dawley
dc.titleExpression of type X collagen and capillary endothelium in condylar cartilage during osteogenic transition - A comparison between adaptive remodelling and natural growth
dc.typeArticle
Author Affiliations
  1. University of Sydney
  2. The University of Hong Kong
  3. Shanghai Jiaotong University
  4. Sichuan University