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Article: Expression of type X collagen and capillary endothelium in condylar cartilage during osteogenic transition - A comparison between adaptive remodelling and natural growth
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TitleExpression of type X collagen and capillary endothelium in condylar cartilage during osteogenic transition - A comparison between adaptive remodelling and natural growth
 
AuthorsShen, G2 3
Zhao, Z4
Kaluarachchi, K1
Bakr Rabie, A1
 
Issue Date2006
 
PublisherOxford University Press. The Journal's web site is located at http://ejo.oxfordjournals.org/
 
CitationEuropean Journal Of Orthodontics, 2006, v. 28 n. 3, p. 210-216 [How to Cite?]
DOI: http://dx.doi.org/10.1093/ejo/cji123
 
AbstractAdaptive remodelling of the condylar cartilage in response to mandibular protrusion constitutes the rationale for bite-jumping appliances to solicit growth modification. By investigating the expression of type X collagen and capillary endothelium, this study was designed to evaluate the osteogenic transition of chondrogenesis during adaptive remodelling of condylar cartilage and compare it with that under natural condylar growth. One hundred female Sprague-Dawley rats, 35 days of age, were divided into five experimental groups (n = 15, fitted with bite-jumping appliances) where condylar adaptation was created by forward repositioning of the mandible, and five control groups (n = 5) where the condyles underwent natural growth. The animals were sacrificed at 3, 7, 14, 21 and 30 days and 7 μm serial sections of the condyles were processed for in situ hybridization and immunohistochemical analyses. The expression of type X collagen in the hypertrophic zone and capillary endothelium in the erosive zone of condylar cartilage were examined to evaluate osteogenic transition, a critical programme leading to endochondral ossification. The results showed that (1) The temporal pattern of the expression of type X collagen and capillary endothelium during condylar adaptation coincided with that during natural condylar growth. (2) The amount of the expression of these two factors during condylar adaptation was significantly higher than that during natural growth (P < 0.001). It is suggested that condylar adaptation in growing rats triggered by mandibular forward positioning enhances osteogenic transition which eventually results in increased bone formation. © The Author 2006. Published by Oxford University Press on behalf of the European Orthodontics Society. All rights reserved.
 
ISSN0141-5387
2012 Impact Factor: 1.078
2012 SCImago Journal Rankings: 0.788
 
DOIhttp://dx.doi.org/10.1093/ejo/cji123
 
ISI Accession Number IDWOS:000238544400003
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorShen, G
 
dc.contributor.authorZhao, Z
 
dc.contributor.authorKaluarachchi, K
 
dc.contributor.authorBakr Rabie, A
 
dc.date.accessioned2010-09-06T05:43:10Z
 
dc.date.available2010-09-06T05:43:10Z
 
dc.date.issued2006
 
dc.description.abstractAdaptive remodelling of the condylar cartilage in response to mandibular protrusion constitutes the rationale for bite-jumping appliances to solicit growth modification. By investigating the expression of type X collagen and capillary endothelium, this study was designed to evaluate the osteogenic transition of chondrogenesis during adaptive remodelling of condylar cartilage and compare it with that under natural condylar growth. One hundred female Sprague-Dawley rats, 35 days of age, were divided into five experimental groups (n = 15, fitted with bite-jumping appliances) where condylar adaptation was created by forward repositioning of the mandible, and five control groups (n = 5) where the condyles underwent natural growth. The animals were sacrificed at 3, 7, 14, 21 and 30 days and 7 μm serial sections of the condyles were processed for in situ hybridization and immunohistochemical analyses. The expression of type X collagen in the hypertrophic zone and capillary endothelium in the erosive zone of condylar cartilage were examined to evaluate osteogenic transition, a critical programme leading to endochondral ossification. The results showed that (1) The temporal pattern of the expression of type X collagen and capillary endothelium during condylar adaptation coincided with that during natural condylar growth. (2) The amount of the expression of these two factors during condylar adaptation was significantly higher than that during natural growth (P < 0.001). It is suggested that condylar adaptation in growing rats triggered by mandibular forward positioning enhances osteogenic transition which eventually results in increased bone formation. © The Author 2006. Published by Oxford University Press on behalf of the European Orthodontics Society. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationEuropean Journal Of Orthodontics, 2006, v. 28 n. 3, p. 210-216 [How to Cite?]
DOI: http://dx.doi.org/10.1093/ejo/cji123
 
dc.identifier.citeulike747413
 
dc.identifier.doihttp://dx.doi.org/10.1093/ejo/cji123
 
dc.identifier.epage216
 
dc.identifier.hkuros124246
 
dc.identifier.isiWOS:000238544400003
 
dc.identifier.issn0141-5387
2012 Impact Factor: 1.078
2012 SCImago Journal Rankings: 0.788
 
dc.identifier.issue3
 
dc.identifier.openurl
 
dc.identifier.pmid16679327
 
dc.identifier.scopuseid_2-s2.0-33745685436
 
dc.identifier.spage210
 
dc.identifier.urihttp://hdl.handle.net/10722/66050
 
dc.identifier.volume28
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://ejo.oxfordjournals.org/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofEuropean Journal of Orthodontics
 
dc.relation.referencesReferences in Scopus
 
dc.rightsEuropean Journal of Orthodontics. Copyright © Oxford University Press.
 
dc.subject.meshAnimals
 
dc.subject.meshBone Remodeling
 
dc.subject.meshCartilage - cytology - metabolism
 
dc.subject.meshCollagen Type X - metabolism
 
dc.subject.meshEndothelium, Vascular - cytology - metabolism
 
dc.subject.meshFemale
 
dc.subject.meshMandibular Condyle - cytology - metabolism
 
dc.subject.meshModels, Animal
 
dc.subject.meshOrthodontic Appliances, Functional - adverse effects
 
dc.subject.meshOsteogenesis
 
dc.subject.meshRats
 
dc.subject.meshRats, Sprague-Dawley
 
dc.titleExpression of type X collagen and capillary endothelium in condylar cartilage during osteogenic transition - A comparison between adaptive remodelling and natural growth
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Shanghai Jiaotong University
  3. University of Sydney
  4. Sichuan University