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Article: Brief exposure to antimycotics reduces the extracellular phospholipase activity of Candida albicans and Candida tropicalis

TitleBrief exposure to antimycotics reduces the extracellular phospholipase activity of Candida albicans and Candida tropicalis
Authors
Issue Date2003
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/CHE
Citation
Chemotherapy, 2003, v. 49 n. 5, p. 243-247 How to Cite?
AbstractBackground: Although the phospholipase activity is considered a potential virulence determinant of the pathogenic Candida species, the effect of antimycotics on this attribute is not known. Hence we evaluated the phospholipase activity in 10 isolates each of Candida albicans and Candida tropicalis, after their exposure to antifungals. Methods: The impact of antimycotics on phospholipase activity was also assessed after exposure of the isolates to sub-minimum inhibitory concentrations of nystatin, amphotericin B and fluconazole. Results: All Candida isolates investigated exhibited phospholipase activity (Pz). In general C. albicans showed relatively higher Pz activity than C. tropicalis, and exposure of the isolates to antimycotics led to a significant (p < 0.05) reduction in the phospholipase activity. Nystatin and amphotericin B, but not fluconazole, significantly reduced the phospholipase activity of both Candida species. Conclusion: These observations, while confirming the higher virulence of C. albicans relative to C. tropicalis, demonstrate for the first time the effect of antifungal agents on extracellular phospholipases of these common opportunistic pathogens. Copyright © 2003 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/66039
ISSN
2015 Impact Factor: 0.992
2015 SCImago Journal Rankings: 0.630
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAnil, Sen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.date.accessioned2010-09-06T05:43:05Z-
dc.date.available2010-09-06T05:43:05Z-
dc.date.issued2003en_HK
dc.identifier.citationChemotherapy, 2003, v. 49 n. 5, p. 243-247en_HK
dc.identifier.issn0009-3157en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66039-
dc.description.abstractBackground: Although the phospholipase activity is considered a potential virulence determinant of the pathogenic Candida species, the effect of antimycotics on this attribute is not known. Hence we evaluated the phospholipase activity in 10 isolates each of Candida albicans and Candida tropicalis, after their exposure to antifungals. Methods: The impact of antimycotics on phospholipase activity was also assessed after exposure of the isolates to sub-minimum inhibitory concentrations of nystatin, amphotericin B and fluconazole. Results: All Candida isolates investigated exhibited phospholipase activity (Pz). In general C. albicans showed relatively higher Pz activity than C. tropicalis, and exposure of the isolates to antimycotics led to a significant (p < 0.05) reduction in the phospholipase activity. Nystatin and amphotericin B, but not fluconazole, significantly reduced the phospholipase activity of both Candida species. Conclusion: These observations, while confirming the higher virulence of C. albicans relative to C. tropicalis, demonstrate for the first time the effect of antifungal agents on extracellular phospholipases of these common opportunistic pathogens. Copyright © 2003 S. Karger AG, Basel.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/CHEen_HK
dc.relation.ispartofChemotherapyen_HK
dc.rightsChemotherapy. Copyright © S Karger AG.en_HK
dc.subject.meshAIDS-Related Opportunistic Infections - microbiologyen_HK
dc.subject.meshAntifungal Agents - pharmacology - therapeutic useen_HK
dc.subject.meshCandida albicans - drug effects - isolation & purificationen_HK
dc.subject.meshCandida tropicalis - drug effects - isolation & purificationen_HK
dc.subject.meshCandidiasis, Oral - drug therapy - microbiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMicrobial Sensitivity Testsen_HK
dc.subject.meshPhospholipases - antagonists & inhibitors - biosynthesisen_HK
dc.titleBrief exposure to antimycotics reduces the extracellular phospholipase activity of Candida albicans and Candida tropicalisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0009-3157&volume=49&spage=243&epage=247&date=2003&atitle=Brief+Exposure+to+Antimycotics+Reduces+the+Extracellular+Phospholipase+Activity+of+Candida+albicans+and+Candida+tropicalisen_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000072448en_HK
dc.identifier.pmid14504435-
dc.identifier.scopuseid_2-s2.0-0141728477en_HK
dc.identifier.hkuros85562en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141728477&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume49en_HK
dc.identifier.issue5en_HK
dc.identifier.spage243en_HK
dc.identifier.epage247en_HK
dc.identifier.isiWOS:000185703700005-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridAnil, S=7006640037en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK

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