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Article: Replicating mesenchymal cells in the condyle and the glenoid fossa during mandibular forward positioning

TitleReplicating mesenchymal cells in the condyle and the glenoid fossa during mandibular forward positioning
Authors
Issue Date2003
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajodo
Citation
American Journal Of Orthodontics And Dentofacial Orthopedics, 2003, v. 123 n. 1, p. 49-57 How to Cite?
AbstractThe purpose of this study was to identify and quantify the temporal sequence of replicating mesenchymal cells during natural growth and mandibular advancement in the condyle and the glenoid fossa. One hundred fifty 35-day-old female Sprague-Dawley rats were randomly divided into 10 experimental groups (10 rats each) and 10 control groups (5 rats each). The experimental groups were fitted with appliances that positioned the mandible forward. One hour before the rats were killed, bromodeoxyuridine (BrdU) was intravenously injected into them. Sections were cut and stained with anti-BrdU antibody to evaluate the number of replicating mesenchymal cells. Cellular uptake of BrdU was quantified with the Leica Qwin (Leica Microsystem Imaging Solutions, Cambridge, United Kingdom) system. The results showed that the numbers of replicating mesenchymal cells during natural growth were highest in the posterior region of the condyle and the anterior region of the glenoid fossa. In the experimental groups, the posterior region had the highest number of replicating cells for both the condyle and the glenoid fossa, with the condyle having 2 to 3 times more replicating cells than the glenoid fossa. The number of replicating mesenchymal cells, which is genetically controlled, influences the growth potential of the condyle and the glenoid fossa. Mandibular protrusion leads to an increase in the number of replicating cells in the temporomandibular joint. Individual variations in the response to growth modification therapy could be a result of the close correlation between mesenchymal cell numbers and growth.
Persistent Identifierhttp://hdl.handle.net/10722/66032
ISSN
2015 Impact Factor: 1.69
2015 SCImago Journal Rankings: 1.249
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorWong, Len_HK
dc.contributor.authorTsai, Men_HK
dc.date.accessioned2010-09-06T05:43:01Z-
dc.date.available2010-09-06T05:43:01Z-
dc.date.issued2003en_HK
dc.identifier.citationAmerican Journal Of Orthodontics And Dentofacial Orthopedics, 2003, v. 123 n. 1, p. 49-57en_HK
dc.identifier.issn0889-5406en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66032-
dc.description.abstractThe purpose of this study was to identify and quantify the temporal sequence of replicating mesenchymal cells during natural growth and mandibular advancement in the condyle and the glenoid fossa. One hundred fifty 35-day-old female Sprague-Dawley rats were randomly divided into 10 experimental groups (10 rats each) and 10 control groups (5 rats each). The experimental groups were fitted with appliances that positioned the mandible forward. One hour before the rats were killed, bromodeoxyuridine (BrdU) was intravenously injected into them. Sections were cut and stained with anti-BrdU antibody to evaluate the number of replicating mesenchymal cells. Cellular uptake of BrdU was quantified with the Leica Qwin (Leica Microsystem Imaging Solutions, Cambridge, United Kingdom) system. The results showed that the numbers of replicating mesenchymal cells during natural growth were highest in the posterior region of the condyle and the anterior region of the glenoid fossa. In the experimental groups, the posterior region had the highest number of replicating cells for both the condyle and the glenoid fossa, with the condyle having 2 to 3 times more replicating cells than the glenoid fossa. The number of replicating mesenchymal cells, which is genetically controlled, influences the growth potential of the condyle and the glenoid fossa. Mandibular protrusion leads to an increase in the number of replicating cells in the temporomandibular joint. Individual variations in the response to growth modification therapy could be a result of the close correlation between mesenchymal cell numbers and growth.en_HK
dc.languageengen_HK
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajodoen_HK
dc.relation.ispartofAmerican Journal of Orthodontics and Dentofacial Orthopedicsen_HK
dc.rightsAmerican Journal of Orthodontics and Dentofacial Orthopedics. Copyright © Mosby, Inc.en_HK
dc.subject.meshActivator Appliancesen_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBromodeoxyuridine - metabolismen_HK
dc.subject.meshCell Divisionen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshMandibular Advancement - instrumentationen_HK
dc.subject.meshMandibular Condyle - cytology - growth & developmenten_HK
dc.subject.meshMaxillofacial Development - physiologyen_HK
dc.subject.meshMesoderm - cytologyen_HK
dc.subject.meshOsteogenesis - physiologyen_HK
dc.subject.meshRandom Allocationen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshTemporal Bone - cytology - growth & developmenten_HK
dc.subject.meshTemporomandibular Joint - cytology - growth & developmenten_HK
dc.titleReplicating mesenchymal cells in the condyle and the glenoid fossa during mandibular forward positioningen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0889-5406&volume=123&spage=49&epage=57&date=2003&atitle=Replicating+mesenchymal+cells+in+the+condyle+and+the+glenoid+fossa+during+mandibular+forward+positioningen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1067/mod.2003.46en_HK
dc.identifier.pmid12532063-
dc.identifier.scopuseid_2-s2.0-0037267286en_HK
dc.identifier.hkuros76135en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037267286&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume123en_HK
dc.identifier.issue1en_HK
dc.identifier.spage49en_HK
dc.identifier.epage57en_HK
dc.identifier.isiWOS:000180709000010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridWong, L=7402092139en_HK
dc.identifier.scopusauthoridTsai, M=7403548929en_HK

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