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Article: The effect of antiretroviral therapy on the prevalence of HIV-associated oral candidiasis in a Spanish cohort

TitleThe effect of antiretroviral therapy on the prevalence of HIV-associated oral candidiasis in a Spanish cohort
Authors
Issue Date2004
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/tripleo
Citation
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, And Endodontics, 2004, v. 97 n. 3, p. 345-350 How to Cite?
AbstractObjective. To investigate the temporal changes in the prevalence of oral candidiasis in a cohort of Spanish human immunodeficiency virus (HIV)-infected individuals, before and after the introduction of highly active antiretroviral therapy (HAART). Study design. Retrospective analysis of a clinical database from "Carlos Haya" Hospital, Málaga, Spain, from 1995 to 2000. The prevalence of oral candidiasis was assessed in 807 HIV/AIDS patients and the temporal progression of its major variants evaluated using a linear regression model. Results. Overall oral candidiasis was prevalent in 30.0% to 48.3% of the cohort throughout and no significant variation in its incidence was noted during the study period. Prevalence of erythematous candidiasis increased from 24.5% (1995) to 45.0% (2000) and pseudomembranous candidiasis decreased from 22.4% (1995) to 5.2% (2000) (P<.05). Hyperplastic candidiasis was not detected in the cohort after the introduction of HAART therapy. Conclusions. Although oral candidiasis in HIV-infected Spanish individuals has not decreased significantly after the introduction of HAART, there appears to be a significant reduction in hyperplastic and pseudomembranous variants of the disease with a compensatory increase in erythematous candidiasis.
Persistent Identifierhttp://hdl.handle.net/10722/65999
ISSN
2011 Impact Factor: 1.457
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCeballosSalobreña, Aen_HK
dc.contributor.authorGaitaínCepeda, Len_HK
dc.contributor.authorCeballosGarcía, Len_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.date.accessioned2010-09-06T05:42:45Z-
dc.date.available2010-09-06T05:42:45Z-
dc.date.issued2004en_HK
dc.identifier.citationOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, And Endodontics, 2004, v. 97 n. 3, p. 345-350en_HK
dc.identifier.issn1079-2104en_HK
dc.identifier.urihttp://hdl.handle.net/10722/65999-
dc.description.abstractObjective. To investigate the temporal changes in the prevalence of oral candidiasis in a cohort of Spanish human immunodeficiency virus (HIV)-infected individuals, before and after the introduction of highly active antiretroviral therapy (HAART). Study design. Retrospective analysis of a clinical database from "Carlos Haya" Hospital, Málaga, Spain, from 1995 to 2000. The prevalence of oral candidiasis was assessed in 807 HIV/AIDS patients and the temporal progression of its major variants evaluated using a linear regression model. Results. Overall oral candidiasis was prevalent in 30.0% to 48.3% of the cohort throughout and no significant variation in its incidence was noted during the study period. Prevalence of erythematous candidiasis increased from 24.5% (1995) to 45.0% (2000) and pseudomembranous candidiasis decreased from 22.4% (1995) to 5.2% (2000) (P<.05). Hyperplastic candidiasis was not detected in the cohort after the introduction of HAART therapy. Conclusions. Although oral candidiasis in HIV-infected Spanish individuals has not decreased significantly after the introduction of HAART, there appears to be a significant reduction in hyperplastic and pseudomembranous variants of the disease with a compensatory increase in erythematous candidiasis.en_HK
dc.languageengen_HK
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/tripleoen_HK
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodonticsen_HK
dc.rightsOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. Copyright © Mosby, Inc.en_HK
dc.subject.meshAIDS-Related Opportunistic Infections - classification - epidemiologyen_HK
dc.subject.meshAntiretroviral Therapy, Highly Active - statistics & numerical dataen_HK
dc.subject.meshCandidiasis, Oral - classification - epidemiologyen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshErythemaen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHIV Infections - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHyperplasiaen_HK
dc.subject.meshIncidenceen_HK
dc.subject.meshLinear Modelsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshSpain - epidemiologyen_HK
dc.titleThe effect of antiretroviral therapy on the prevalence of HIV-associated oral candidiasis in a Spanish cohorten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1079-2104&volume=97&spage=345&epage=50&date=2004&atitle=The+effect+of+antiretroviral+therapy+on+the+prevalence+of+HIV-associated+oral+candidiasis+in+a+Spanish+cohorten_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.tripleo.2003.09.016en_HK
dc.identifier.pmid15024359-
dc.identifier.scopuseid_2-s2.0-1542299095en_HK
dc.identifier.hkuros85754en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1542299095&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume97en_HK
dc.identifier.issue3en_HK
dc.identifier.spage345en_HK
dc.identifier.epage350en_HK
dc.identifier.isiWOS:000220238000014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCeballosSalobreña, A=6603003832en_HK
dc.identifier.scopusauthoridGaitaínCepeda, L=7801515261en_HK
dc.identifier.scopusauthoridCeballosGarcía, L=6507299976en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK

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