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Article: Repeated mechanical loading enhances the expression of Indian hedgehog in condylar cartilage

TitleRepeated mechanical loading enhances the expression of Indian hedgehog in condylar cartilage
Authors
KeywordsCondylar cartilage
Ihh
Repeated Loading
Issue Date2006
PublisherFrontiers in Bioscience. The Journal's web site is located at http://www.frontbiosci.org/
Citation
Frontiers In Bioscience, 2006, v. 11 n. 1 P.889-1198, p. 943-948 How to Cite?
AbstractIndian hedgehog (Ihh) acts as a mechanotransduction mediator that converts mechanical strain into cellular proliferation and cartilage formation in mandibular condylar cartilage. The aim of this study was to examine the effect of repeated mechanical strain on the level of expression of Ihh and type II collagen mRNA in condylar growth. Two hundred and eighty 35 days old Sprague-Dawley rats were divided into 10 experimental and 10 control groups. Repeated mechanical loading was applied by advancing the mandible in a stepwise manner by fitting a stepwise bite jumping appliance. Animals were sacrificed together with their matched controls on 10 different time points. Total RNA was extracted from condylar cartilage immediately after dissection. Ihh and type II collagen mRNA was quantified using real-time PCR. In the experimental group, Ihh mRNA increased significantly on experimental day 7. Upon the second advancement, another peak was elicited 7 days later. Type II collagen showed a significant increase on days 21 and 44 of advancement. This indicated that mechanical loading in a repeated manner, triggers the expression of Ihh which in turn increases the number of replicating mesenchymal cells as well as the amount of the cartilage formed. Taken together these events increase condylar growth.
Persistent Identifierhttp://hdl.handle.net/10722/65977
ISSN
2015 Impact Factor: 2.484
2015 SCImago Journal Rankings: 1.583
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, TCSen_HK
dc.contributor.authorChiu, KWKen_HK
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorHägg, Uen_HK
dc.date.accessioned2010-09-06T05:42:34Z-
dc.date.available2010-09-06T05:42:34Z-
dc.date.issued2006en_HK
dc.identifier.citationFrontiers In Bioscience, 2006, v. 11 n. 1 P.889-1198, p. 943-948en_HK
dc.identifier.issn1093-9946en_HK
dc.identifier.urihttp://hdl.handle.net/10722/65977-
dc.description.abstractIndian hedgehog (Ihh) acts as a mechanotransduction mediator that converts mechanical strain into cellular proliferation and cartilage formation in mandibular condylar cartilage. The aim of this study was to examine the effect of repeated mechanical strain on the level of expression of Ihh and type II collagen mRNA in condylar growth. Two hundred and eighty 35 days old Sprague-Dawley rats were divided into 10 experimental and 10 control groups. Repeated mechanical loading was applied by advancing the mandible in a stepwise manner by fitting a stepwise bite jumping appliance. Animals were sacrificed together with their matched controls on 10 different time points. Total RNA was extracted from condylar cartilage immediately after dissection. Ihh and type II collagen mRNA was quantified using real-time PCR. In the experimental group, Ihh mRNA increased significantly on experimental day 7. Upon the second advancement, another peak was elicited 7 days later. Type II collagen showed a significant increase on days 21 and 44 of advancement. This indicated that mechanical loading in a repeated manner, triggers the expression of Ihh which in turn increases the number of replicating mesenchymal cells as well as the amount of the cartilage formed. Taken together these events increase condylar growth.en_HK
dc.languageengen_HK
dc.publisherFrontiers in Bioscience. The Journal's web site is located at http://www.frontbiosci.org/en_HK
dc.relation.ispartofFrontiers in Bioscienceen_HK
dc.subjectCondylar cartilageen_HK
dc.subjectIhhen_HK
dc.subjectRepeated Loadingen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBone Developmenten_HK
dc.subject.meshCartilage - metabolismen_HK
dc.subject.meshCell Proliferationen_HK
dc.subject.meshCollagen - metabolismen_HK
dc.subject.meshCollagen Type IIen_HK
dc.subject.meshDNA Primers - chemistryen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHedgehog Proteinsen_HK
dc.subject.meshIntercellular Signaling Peptides and Proteins - metabolismen_HK
dc.subject.meshMandibular Condyle - pathologyen_HK
dc.subject.meshModels, Statisticalen_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshRNA - metabolismen_HK
dc.subject.meshRNA, Messenger - metabolismen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshStress, Mechanicalen_HK
dc.subject.meshTemperatureen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshTrans-Activators - metabolismen_HK
dc.titleRepeated mechanical loading enhances the expression of Indian hedgehog in condylar cartilageen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1093-9946&volume=11&spage=943&epage=948&date=2006&atitle=Repeated+mechanical+loading+enhances+the+expression+of+Indian+hedgehog+in+condylar+cartilageen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.emailHägg, U: euohagg@hkusua.hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.identifier.authorityHägg, U=rp00020en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2741/1850en_HK
dc.identifier.pmid16146784-
dc.identifier.scopuseid_2-s2.0-32844470804en_HK
dc.identifier.hkuros110878en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-32844470804&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue1 P.889-1198en_HK
dc.identifier.spage943en_HK
dc.identifier.epage948en_HK
dc.identifier.isiWOS:000232528000076-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNg, TCS=36799699400en_HK
dc.identifier.scopusauthoridChiu, KWK=36950846800en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridHägg, U=7006790279en_HK

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