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Article: Preservation of quality of life after intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: Results of a prospective longitudinal study

TitlePreservation of quality of life after intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: Results of a prospective longitudinal study
Authors
KeywordsIntensity-modulated radiotherapy
Nasopharyngeal carcinoma
Parotid sparing
Quality of life
Salivary flow
Issue Date2006
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137
Citation
Head And Neck, 2006, v. 28 n. 8, p. 712-722 How to Cite?
AbstractBackground. Xerostomia is a ubiquitous complication after conventional radiotherapy for nasopharyngeal carcinoma (NPC) that seriously impairs patient quality of life (QOL). The effect on QOL of parotid-sparing intensity-modulated radiotherapy (IMRT) for early-stage NPC was assessed prospectively. Methods. Thirty-two patients with T1-2, N0-1, M0 NPC received IMRT. Saliva flow was measured, and the Medical Outcomes Short Form 36 (SF-36), European Organization for Research and Treatment of Cancer (EORTC) core, and EORTC head and neck module (QLQ-H&N35) questionnaires were completed at baseline and 2, 6, and 12 months after IMRT. Results. Saliva flow recovered to at least 25% of baseline in most cases after 1 year. Physical function, fatigue, and vitality were problems at 2 months and then resolved (p ≤ .002). Global health scales showed continuous improvement in QOL after treatment (p ≤ .004). Xerostomia and sticky saliva were problems 2 months after treatment; thereafter, continuous improvement occurred (p ≤ .001). Xerostomia scores correlated with general aspects of QOL (p ≤ .044). Conclusion. IMRT for early-stage disease preserved key aspects of QOL, and a reduction in xerostomia symptoms enhanced broader aspects of QOL. © 2006 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/65973
ISSN
2015 Impact Factor: 2.76
2015 SCImago Journal Rankings: 1.233
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMcMillan, ASen_HK
dc.contributor.authorPow, EHNen_HK
dc.contributor.authorKwong, DLWen_HK
dc.contributor.authorWong, MCMen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorLeung, LHTen_HK
dc.contributor.authorLeung, WKen_HK
dc.date.accessioned2010-09-06T05:42:32Z-
dc.date.available2010-09-06T05:42:32Z-
dc.date.issued2006en_HK
dc.identifier.citationHead And Neck, 2006, v. 28 n. 8, p. 712-722en_HK
dc.identifier.issn1043-3074en_HK
dc.identifier.urihttp://hdl.handle.net/10722/65973-
dc.description.abstractBackground. Xerostomia is a ubiquitous complication after conventional radiotherapy for nasopharyngeal carcinoma (NPC) that seriously impairs patient quality of life (QOL). The effect on QOL of parotid-sparing intensity-modulated radiotherapy (IMRT) for early-stage NPC was assessed prospectively. Methods. Thirty-two patients with T1-2, N0-1, M0 NPC received IMRT. Saliva flow was measured, and the Medical Outcomes Short Form 36 (SF-36), European Organization for Research and Treatment of Cancer (EORTC) core, and EORTC head and neck module (QLQ-H&N35) questionnaires were completed at baseline and 2, 6, and 12 months after IMRT. Results. Saliva flow recovered to at least 25% of baseline in most cases after 1 year. Physical function, fatigue, and vitality were problems at 2 months and then resolved (p ≤ .002). Global health scales showed continuous improvement in QOL after treatment (p ≤ .004). Xerostomia and sticky saliva were problems 2 months after treatment; thereafter, continuous improvement occurred (p ≤ .001). Xerostomia scores correlated with general aspects of QOL (p ≤ .044). Conclusion. IMRT for early-stage disease preserved key aspects of QOL, and a reduction in xerostomia symptoms enhanced broader aspects of QOL. © 2006 Wiley Periodicals, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/38137en_HK
dc.relation.ispartofHead and Necken_HK
dc.subjectIntensity-modulated radiotherapyen_HK
dc.subjectNasopharyngeal carcinomaen_HK
dc.subjectParotid sparingen_HK
dc.subjectQuality of lifeen_HK
dc.subjectSalivary flowen_HK
dc.subject.meshAdulten_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHealth Status Indicatorsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNasopharyngeal Neoplasms - pathology - radiotherapy - surgeryen_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.subject.meshParotid Gland - radiation effectsen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshQuality of Lifeen_HK
dc.subject.meshRadiotherapy Dosageen_HK
dc.subject.meshRadiotherapy, Intensity-Modulateden_HK
dc.subject.meshSalivation - radiation effectsen_HK
dc.subject.meshXerostomia - prevention & controlen_HK
dc.titlePreservation of quality of life after intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: Results of a prospective longitudinal studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0017-8748&volume=28&spage=712&epage=722&date=2006&atitle=Preservation+of+quality+of+life+after+intensity-modulated+radiotherapy+for+early-stage+nasopharyngeal+carcinoma:+Results+of+a+prospective+longitudinal+studyen_HK
dc.identifier.emailMcMillan, AS: annemcmillan@hku.hken_HK
dc.identifier.emailPow, EHN: ehnpow@hku.hken_HK
dc.identifier.emailKwong, DLW: dlwkwong@hku.hken_HK
dc.identifier.emailWong, MCM: mcmwong@hkucc.hku.hken_HK
dc.identifier.emailLeung, WK: ewkleung@hkucc.hku.hken_HK
dc.identifier.authorityMcMillan, AS=rp00014en_HK
dc.identifier.authorityPow, EHN=rp00030en_HK
dc.identifier.authorityKwong, DLW=rp00414en_HK
dc.identifier.authorityWong, MCM=rp00024en_HK
dc.identifier.authorityLeung, WK=rp00019en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hed.20378en_HK
dc.identifier.pmid16475203-
dc.identifier.scopuseid_2-s2.0-33746353435en_HK
dc.identifier.hkuros116926en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746353435&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue8en_HK
dc.identifier.spage712en_HK
dc.identifier.epage722en_HK
dc.identifier.isiWOS:000239179900007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMcMillan, AS=7102843317en_HK
dc.identifier.scopusauthoridPow, EHN=6603825799en_HK
dc.identifier.scopusauthoridKwong, DLW=15744231600en_HK
dc.identifier.scopusauthoridWong, MCM=26029250900en_HK
dc.identifier.scopusauthoridSham, JST=24472255400en_HK
dc.identifier.scopusauthoridLeung, LHT=7202048113en_HK
dc.identifier.scopusauthoridLeung, WK=25224691800en_HK

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