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Article: Doxycycline: Are its 'side-effects' a contra-indication to its use?

TitleDoxycycline: Are its 'side-effects' a contra-indication to its use?
Authors
KeywordsDoxycycline
Tetracycline
Tooth discolouration
Issue Date2007
PublisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.asp
Citation
Hong Kong Journal Of Paediatrics, 2007, v. 12 n. 2, p. 105-110 How to Cite?
AbstractObjectives: To briefly outline the development and reasons for the decline in the clinical use of tetracyclines, and to consider if the side-effects of doxycycline a contra-indication to its use. Data Sources: Literature search of MEDLINE from 1950 to 2005. Study Selection: Literature and data related to doxycycline, tetracycline and tooth discolouration. Data Extraction: Relevant information and data were reviewed by the authors. Data Synthesis: The established side-effect of tooth discolouration has led to the formation of guidelines to restrict the use of the tetracyclines in susceptible groups of patients, such as pregnant women and throughout childhood. The severity of the discolouration is likely to be related to the different homologues of the tetracyclines, dose, frequency, the stage of odontogenesis, and the duration of the therapy. The majority of published clinical data indicates that doxycycline can be prescribed for children because it causes the least severe type of tooth discolouration. However, there has not been a prospective, randomised, double blind study that compared doxycycline with other tetracyclines to make a definitive statement about the decreased incidence of dental discolouration by doxycycline. The propriety of carrying out a clinical trial using doxycycline involving children when the side-effects of tetracyclines are already well known is also disputable. Conclusions: Caution should be exercised when prescribing doxycycline to children who should be kept under long term review because of the insufficient data concerning the discolouration of the developing teeth.
Persistent Identifierhttp://hdl.handle.net/10722/65892
ISSN
2015 Impact Factor: 0.194
2015 SCImago Journal Rankings: 0.123
References

 

DC FieldValueLanguage
dc.contributor.authorKing, NMen_HK
dc.contributor.authorWong, HMen_HK
dc.contributor.authorKumar, VLNen_HK
dc.date.accessioned2010-09-06T05:41:52Z-
dc.date.available2010-09-06T05:41:52Z-
dc.date.issued2007en_HK
dc.identifier.citationHong Kong Journal Of Paediatrics, 2007, v. 12 n. 2, p. 105-110en_HK
dc.identifier.issn1013-9923en_HK
dc.identifier.urihttp://hdl.handle.net/10722/65892-
dc.description.abstractObjectives: To briefly outline the development and reasons for the decline in the clinical use of tetracyclines, and to consider if the side-effects of doxycycline a contra-indication to its use. Data Sources: Literature search of MEDLINE from 1950 to 2005. Study Selection: Literature and data related to doxycycline, tetracycline and tooth discolouration. Data Extraction: Relevant information and data were reviewed by the authors. Data Synthesis: The established side-effect of tooth discolouration has led to the formation of guidelines to restrict the use of the tetracyclines in susceptible groups of patients, such as pregnant women and throughout childhood. The severity of the discolouration is likely to be related to the different homologues of the tetracyclines, dose, frequency, the stage of odontogenesis, and the duration of the therapy. The majority of published clinical data indicates that doxycycline can be prescribed for children because it causes the least severe type of tooth discolouration. However, there has not been a prospective, randomised, double blind study that compared doxycycline with other tetracyclines to make a definitive statement about the decreased incidence of dental discolouration by doxycycline. The propriety of carrying out a clinical trial using doxycycline involving children when the side-effects of tetracyclines are already well known is also disputable. Conclusions: Caution should be exercised when prescribing doxycycline to children who should be kept under long term review because of the insufficient data concerning the discolouration of the developing teeth.en_HK
dc.languageengen_HK
dc.publisherMedcom Limited. The Journal's web site is located at http://www.hkjpaed.org/index.aspen_HK
dc.relation.ispartofHong Kong Journal of Paediatricsen_HK
dc.subjectDoxycyclineen_HK
dc.subjectTetracyclineen_HK
dc.subjectTooth discolourationen_HK
dc.titleDoxycycline: Are its 'side-effects' a contra-indication to its use?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1013-9923&volume=12&issue=2&spage=105&epage=110&date=2007&atitle=Doxycycline:+Are+its+%27side-effects%27+a+contra-indication+to+its+use?en_HK
dc.identifier.emailKing, NM: hhdbknm@hkucc.hku.hken_HK
dc.identifier.emailWong, HM: wonghmg@hkucc.hku.hken_HK
dc.identifier.authorityKing, NM=rp00006en_HK
dc.identifier.authorityWong, HM=rp00042en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-34247506898en_HK
dc.identifier.hkuros126738en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247506898&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue2en_HK
dc.identifier.spage105en_HK
dc.identifier.epage110en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridKing, NM=7201762850en_HK
dc.identifier.scopusauthoridWong, HM=12765604700en_HK
dc.identifier.scopusauthoridKumar, VLN=55267764200en_HK

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