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Article: Effect of puerarin on bone formation

TitleEffect of puerarin on bone formation
Authors
KeywordsBone graft
Bone repair
Phytoestrogen
Pueraria lobata
Puerarin
Issue Date2007
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/joca
Citation
Osteoarthritis And Cartilage, 2007, v. 15 n. 8, p. 894-899 How to Cite?
AbstractObjective: Puerarin is one of the major phytoestrogens isolated from Pueraria lobata, a Chinese medicine known as Gegen. Our laboratory compared the amount of new bone produced by puerarin in collagen matrix (carrier) to that produced by the collagen matrix alone. Method: Eighteen bone defects, 5 mm by 10 mm were created in the parietal bone of nine New Zealand White rabbits. In the experimental group, six defects were grafted with puerarin solution mixed with collagen matrix. In the control groups, six defects were grafted with collagen matrix alone (active control) and six were left empty (passive control). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Serial sections were cut across each defect. No new bone was formed in the passive control group. Quantitative analysis of new bone formation was made on 100 sections (10 sections in each defect, in five defects randomly selected in each of the experimental group and active control group) using image analysis. Results: A total of 554% more new bone was present in defects grafted with puerarin in collagen matrix than those grafted with the collagen matrix alone. Conclusion: Puerarin in collagen matrix has the effect of increasing new bone formation locally and can be used for bone grafting or for bone induction often required in surgery. © 2007 Osteoarthritis Research Society International.
Persistent Identifierhttp://hdl.handle.net/10722/65877
ISSN
2015 Impact Factor: 4.535
2015 SCImago Journal Rankings: 1.901
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, Ren_HK
dc.contributor.authorRabie, Ben_HK
dc.date.accessioned2010-09-06T05:41:44Z-
dc.date.available2010-09-06T05:41:44Z-
dc.date.issued2007en_HK
dc.identifier.citationOsteoarthritis And Cartilage, 2007, v. 15 n. 8, p. 894-899en_HK
dc.identifier.issn1063-4584en_HK
dc.identifier.urihttp://hdl.handle.net/10722/65877-
dc.description.abstractObjective: Puerarin is one of the major phytoestrogens isolated from Pueraria lobata, a Chinese medicine known as Gegen. Our laboratory compared the amount of new bone produced by puerarin in collagen matrix (carrier) to that produced by the collagen matrix alone. Method: Eighteen bone defects, 5 mm by 10 mm were created in the parietal bone of nine New Zealand White rabbits. In the experimental group, six defects were grafted with puerarin solution mixed with collagen matrix. In the control groups, six defects were grafted with collagen matrix alone (active control) and six were left empty (passive control). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Serial sections were cut across each defect. No new bone was formed in the passive control group. Quantitative analysis of new bone formation was made on 100 sections (10 sections in each defect, in five defects randomly selected in each of the experimental group and active control group) using image analysis. Results: A total of 554% more new bone was present in defects grafted with puerarin in collagen matrix than those grafted with the collagen matrix alone. Conclusion: Puerarin in collagen matrix has the effect of increasing new bone formation locally and can be used for bone grafting or for bone induction often required in surgery. © 2007 Osteoarthritis Research Society International.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jocaen_HK
dc.relation.ispartofOsteoarthritis and Cartilageen_HK
dc.subjectBone graften_HK
dc.subjectBone repairen_HK
dc.subjectPhytoestrogenen_HK
dc.subjectPueraria lobataen_HK
dc.subjectPuerarinen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBone Transplantationen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshDrugs, Chinese Herbal - chemistry - pharmacologyen_HK
dc.subject.meshFracture Healing - drug effectsen_HK
dc.subject.meshFractures, Bone - drug therapy - pathologyen_HK
dc.subject.meshIsoflavones - chemistry - pharmacologyen_HK
dc.subject.meshOsteogenesis - drug effectsen_HK
dc.subject.meshParietal Bone - drug effects - injuries - pathologyen_HK
dc.subject.meshRabbitsen_HK
dc.subject.meshVasodilator Agents - chemistry - pharmacologyen_HK
dc.titleEffect of puerarin on bone formationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1063-4584&volume=15&spage=894&epage=899&date=2007&atitle=Effect+of+puerarin+on+bone+formation+en_HK
dc.identifier.emailWong, R: fyoung@hku.hken_HK
dc.identifier.emailRabie, B: rabie@hku.hken_HK
dc.identifier.authorityWong, R=rp00038en_HK
dc.identifier.authorityRabie, B=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.joca.2007.02.009en_HK
dc.identifier.pmid17379543-
dc.identifier.scopuseid_2-s2.0-34547697916en_HK
dc.identifier.hkuros132909en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547697916&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue8en_HK
dc.identifier.spage894en_HK
dc.identifier.epage899en_HK
dc.identifier.isiWOS:000249272300006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, R=7402127170en_HK
dc.identifier.scopusauthoridRabie, B=7007172734en_HK

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