Article: Beneficial effects of cinnamon proanthocyanidins on the formation of specific advanced glycation endproducts and methylglyoxal-induced impairment on glucose consumption

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TitleBeneficial effects of cinnamon proanthocyanidins on the formation of specific advanced glycation endproducts and methylglyoxal-induced impairment on glucose consumption
AuthorsPeng, X1
Ma, J1
Chao, J1
Sun, Z1
Chang, RCC1
Tse, I1
Li, ETS1
Chen, F1
Wang, M1
KeywordsCinnamon bark
Insulin signaling
MGO
N ε- (carboxymethyl)lysine (CML)
Pentosidine
Proanthocyanidin
Issue Date2010
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcau
CitationJournal Of Agricultural And Food Chemistry, 2010, v. 58 n. 11, p. 6692-6696 [How to Cite?]
DOI: http://dx.doi.org/10.1021/jf100538t
AbstractAdvanced glycation endproducts (AGEs) are a group of complex and heterogeneous compounds formed from nonenzymatic reactions. The accumulation of AGEs in vivo has been implicated as a major pathogenic process in diabetic complications and other health disorders, such as atherosclerosis and Alzheimerâs disease, and normal aging. In this study, we investigate the inhibitory effects of cinnamon bark proanthocyanidins, catechin, epicatechin, and procyanidin B2 on the formation of specific AGE representatives including pentosidine, N ε-(carboxymethyl)lysine (CML), and methylglyoxal (MGO) derived AGEs. These compounds displayed obvious inhibitory effects on these specific AGEs, which are largely attributed to both their antioxidant activities and carbonyl scavenging capacities. Meanwhile, in terms of their potent MGO scavenging capacities, effects of these proanthocyanidins on insulin signaling pathways interfered by MGO were evaluated in 3T3-L1 adipocytes. According to the results, proanthocyanidins exerted protective effects on glucose consumption impaired by MGO in 3T3-L1 fat cells. © 2010 American Chemical Society.
ISSN0021-8561
2011 Impact Factor: 2.823
2011 SCImago Journal Rankings: 0.144
DOIhttp://dx.doi.org/10.1021/jf100538t
ISI Accession Number IDWOS:000278149500022
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorPeng, X
dc.contributor.authorMa, J
dc.contributor.authorChao, J
dc.contributor.authorSun, Z
dc.contributor.authorChang, RCC
dc.contributor.authorTse, I
dc.contributor.authorLi, ETS
dc.contributor.authorChen, F
dc.contributor.authorWang, M
dc.date.accessioned2010-08-09T07:23:38Z
dc.date.available2010-08-09T07:23:38Z
dc.date.issued2010
dc.description.abstractAdvanced glycation endproducts (AGEs) are a group of complex and heterogeneous compounds formed from nonenzymatic reactions. The accumulation of AGEs in vivo has been implicated as a major pathogenic process in diabetic complications and other health disorders, such as atherosclerosis and Alzheimerâs disease, and normal aging. In this study, we investigate the inhibitory effects of cinnamon bark proanthocyanidins, catechin, epicatechin, and procyanidin B2 on the formation of specific AGE representatives including pentosidine, N ε-(carboxymethyl)lysine (CML), and methylglyoxal (MGO) derived AGEs. These compounds displayed obvious inhibitory effects on these specific AGEs, which are largely attributed to both their antioxidant activities and carbonyl scavenging capacities. Meanwhile, in terms of their potent MGO scavenging capacities, effects of these proanthocyanidins on insulin signaling pathways interfered by MGO were evaluated in 3T3-L1 adipocytes. According to the results, proanthocyanidins exerted protective effects on glucose consumption impaired by MGO in 3T3-L1 fat cells. © 2010 American Chemical Society.
dc.description.natureabstract
dc.identifier.citationJournal Of Agricultural And Food Chemistry, 2010, v. 58 n. 11, p. 6692-6696 [How to Cite?]
DOI: http://dx.doi.org/10.1021/jf100538t
dc.identifier.doihttp://dx.doi.org/10.1021/jf100538t
dc.identifier.epage6696
dc.identifier.hkuros170843
dc.identifier.isiWOS:000278149500022
dc.identifier.issn0021-8561
2011 Impact Factor: 2.823
2011 SCImago Journal Rankings: 0.144
dc.identifier.issue11
dc.identifier.openurl
dc.identifier.pmid20476737
dc.identifier.scopuseid_2-s2.0-77953155163
dc.identifier.spage6692
dc.identifier.urihttp://hdl.handle.net/10722/65459
dc.identifier.volume58
dc.languageeng
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcau
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Agricultural and Food Chemistry
dc.relation.referencesReferences in Scopus
dc.subjectCinnamon bark
dc.subjectInsulin signaling
dc.subjectMGO
dc.subjectN ε- (carboxymethyl)lysine (CML)
dc.subjectPentosidine
dc.subjectProanthocyanidin
dc.titleBeneficial effects of cinnamon proanthocyanidins on the formation of specific advanced glycation endproducts and methylglyoxal-induced impairment on glucose consumption
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine