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Conference Paper: Synergy of ischemic pre- and immediate post-conditioning attenuates intestinal ischemia-reperfusion injury in rats

TitleSynergy of ischemic pre- and immediate post-conditioning attenuates intestinal ischemia-reperfusion injury in rats
Authors
KeywordsBiology
Issue Date2009
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
The 2009 Experimental Biology Meeting, New Orleans, LA., 18-22 April 2009. In The FASEB Journal, 2009, v. 23 meeting abstract suppl., abstract no. 576.6 How to Cite?
AbstractIschemic postconditioning (IPo) is similarly effective as ischemic preconditioning (IPC) in attenuating intestinal ischemia-reperfusion injury (IIRI). It is unknown whether IPC and IPo can confer synergistic effect in attenuating IIRI, and whether delayed IPo is as effective as immediate IPo. Rats were randomly divided into six groups (n=8 each): Sham; IIRI, produced by clamping the superior mesenteric artery (SMA) for 60 min followed by 60 min of reperfusion; IPC, elicited by 10 min ischemia followed by 10 min reperfusion before inducing IIRI; immediate IPo, achieved by 3 cycles of 30 s reperfusion and SMA reocclusion immediately at the onset of reperfusion; Joint IPC and immediate IPo; and delayed IPo, achieved by 3 cycles of 30 s reperfusion and SMA reocclusion started 3 min after the onset of full reperfusion. Intestinal injury evidenced by increases in Chiu's scores and intestine tissue wet-to-dry weigh ratio as well as elevations of plasma tumor necrosis factor-alpha and intestinal tissue lipid peroxidation product malondialdehyde were apparent in the IIRI untreated group. These changes were significantly attenuated by IPC, immediate IPo and their combination, but not by delayed IPo. Joint IPC and immediate IPo conferred superior protective effects than they were applied alone (P<0.05), indicative of a synergy of ischemic pre- and immediate post-conditioning in attenuating IIRI in rats.
Persistent Identifierhttp://hdl.handle.net/10722/63431
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorLiu, Ken_HK
dc.contributor.authorLi, Yen_HK
dc.contributor.authorChen, Sen_HK
dc.contributor.authorHuang, Wen_HK
dc.contributor.authorLiu, Yen_HK
dc.contributor.authorXia, Zen_HK
dc.date.accessioned2010-07-13T04:23:29Z-
dc.date.available2010-07-13T04:23:29Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 2009 Experimental Biology Meeting, New Orleans, LA., 18-22 April 2009. In The FASEB Journal, 2009, v. 23 meeting abstract suppl., abstract no. 576.6en_HK
dc.identifier.issn0892-6638en_HK
dc.identifier.urihttp://hdl.handle.net/10722/63431-
dc.description.abstractIschemic postconditioning (IPo) is similarly effective as ischemic preconditioning (IPC) in attenuating intestinal ischemia-reperfusion injury (IIRI). It is unknown whether IPC and IPo can confer synergistic effect in attenuating IIRI, and whether delayed IPo is as effective as immediate IPo. Rats were randomly divided into six groups (n=8 each): Sham; IIRI, produced by clamping the superior mesenteric artery (SMA) for 60 min followed by 60 min of reperfusion; IPC, elicited by 10 min ischemia followed by 10 min reperfusion before inducing IIRI; immediate IPo, achieved by 3 cycles of 30 s reperfusion and SMA reocclusion immediately at the onset of reperfusion; Joint IPC and immediate IPo; and delayed IPo, achieved by 3 cycles of 30 s reperfusion and SMA reocclusion started 3 min after the onset of full reperfusion. Intestinal injury evidenced by increases in Chiu's scores and intestine tissue wet-to-dry weigh ratio as well as elevations of plasma tumor necrosis factor-alpha and intestinal tissue lipid peroxidation product malondialdehyde were apparent in the IIRI untreated group. These changes were significantly attenuated by IPC, immediate IPo and their combination, but not by delayed IPo. Joint IPC and immediate IPo conferred superior protective effects than they were applied alone (P<0.05), indicative of a synergy of ischemic pre- and immediate post-conditioning in attenuating IIRI in rats.-
dc.languageengen_HK
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/en_HK
dc.relation.ispartofThe FASEB Journal-
dc.subjectBiology-
dc.titleSynergy of ischemic pre- and immediate post-conditioning attenuates intestinal ischemia-reperfusion injury in ratsen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0892-6638&volume=23 &issue=Meeting abstract suppl.&spage=&epage=&date=2009&atitle=Synergy+of+ischemic+pre-+and+immediate+post-conditioning+attenuates+intestinal+ischemia-reperfusion+injury+in+ratsen_HK
dc.identifier.emailLiu, K: liukexuan807@yahoo.com.cnen_HK
dc.identifier.emailXia, Z: zhengyuan_xia@yahoo.comen_HK
dc.identifier.hkuros162387en_HK
dc.identifier.volume23-
dc.identifier.issuemeeting abstract suppl.-
dc.description.otherThe Experimental Biology 2009, New Orleans, LA., 18-22 April 2009. In The FASEB Journal, 2009, v. 23 Meeting abstract suppl., abstract no. 576.6-

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