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Conference Paper: Single-Marker and Haplotype Analyses for DetectingImprinting Effects in Families with Both Parents and Families with One Parent

TitleSingle-Marker and Haplotype Analyses for DetectingImprinting Effects in Families with Both Parents and Families with One Parent
Authors
Issue Date2008
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35841
Citation
17th Annual Meeting of the International Genetic Epidemiological Society, 2008. In Genetic Epidemiology, 2008, v. 32 n. 7, p. 724 How to Cite?
AbstractGenomic imprinting is important in genetic trait study. Some statistical methods may be invalid or fail to detect linkage or association for imprinted genes. For case-parents trios, the parental-asymmetry test (PAT) is simple and powerful in detecting imprinting. Meanwhile, haplotype analysis is generally advantageous over single-marker analysis in complex trait study. As such, HAP-PAT, an extension of PAT, was constructed in haplotype analysis. However, it is common to collect families with both parents and those with only one parent. In this paper, when only one parent is available for each family, we develop 1-PAT to test for imprinting using single marker analysis. Combining families with both parent sand those with one parent, C-PAT is proposed. We also introduce HAP-1-PAT and HAP-C-PAT to test for imprinting using haplotype analysis. A permutation procedure is devised to determine the significance of HAP-1-PAT and HAP-C-PAT. The validity of the statistics is verified by simulation. A power study shows that using the additional information from families with one parent in the analysis greatly improves the power of the tests, compared to that based on families with both parents. Also, utilizing all affected children in each family, the proposed tests have a higher power than when only one affected child from each family is selected. Furthermore, there are significant gains in power from haplotype analysis compared to single-marker analysis.
Persistent Identifierhttp://hdl.handle.net/10722/63166
ISSN
2015 Impact Factor: 2.553
2015 SCImago Journal Rankings: 2.101

 

DC FieldValueLanguage
dc.contributor.authorZhou, Jen_HK
dc.contributor.authorFung, TWKen_HK
dc.contributor.authorLin, Sen_HK
dc.contributor.authorHu, Yen_HK
dc.date.accessioned2010-07-13T04:17:32Z-
dc.date.available2010-07-13T04:17:32Z-
dc.date.issued2008en_HK
dc.identifier.citation17th Annual Meeting of the International Genetic Epidemiological Society, 2008. In Genetic Epidemiology, 2008, v. 32 n. 7, p. 724en_HK
dc.identifier.issn0741-0395en_HK
dc.identifier.urihttp://hdl.handle.net/10722/63166-
dc.description.abstractGenomic imprinting is important in genetic trait study. Some statistical methods may be invalid or fail to detect linkage or association for imprinted genes. For case-parents trios, the parental-asymmetry test (PAT) is simple and powerful in detecting imprinting. Meanwhile, haplotype analysis is generally advantageous over single-marker analysis in complex trait study. As such, HAP-PAT, an extension of PAT, was constructed in haplotype analysis. However, it is common to collect families with both parents and those with only one parent. In this paper, when only one parent is available for each family, we develop 1-PAT to test for imprinting using single marker analysis. Combining families with both parent sand those with one parent, C-PAT is proposed. We also introduce HAP-1-PAT and HAP-C-PAT to test for imprinting using haplotype analysis. A permutation procedure is devised to determine the significance of HAP-1-PAT and HAP-C-PAT. The validity of the statistics is verified by simulation. A power study shows that using the additional information from families with one parent in the analysis greatly improves the power of the tests, compared to that based on families with both parents. Also, utilizing all affected children in each family, the proposed tests have a higher power than when only one affected child from each family is selected. Furthermore, there are significant gains in power from haplotype analysis compared to single-marker analysis.-
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35841en_HK
dc.relation.ispartofGenetic Epidemiology-
dc.rightsGenetic Epidemiology. Copyright © John Wiley & Sons, Inc.en_HK
dc.titleSingle-Marker and Haplotype Analyses for DetectingImprinting Effects in Families with Both Parents and Families with One Parenten_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0741-0395&volume=32&spage=724&epage=724&date=2008&atitle=Single+marker+and+haplotype+analyses+for+detecting+imprinting+effects+in+families+with+both+parents+and+families+with+one+parenten_HK
dc.identifier.emailFung, TWK: wingfung@hku.hken_HK
dc.identifier.emailHu, Y: yqhu@hku.hken_HK
dc.identifier.authorityFung, TWK=rp00696en_HK
dc.identifier.authorityHu, Y=rp00708en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/gepi.20367-
dc.identifier.hkuros158109en_HK

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