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Conference Paper: Role of extracellular signal-related kinases in the pathophysiology of vascular dysfunction in aging and hypertension

TitleRole of extracellular signal-related kinases in the pathophysiology of vascular dysfunction in aging and hypertension
Authors
Issue Date2009
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/JVR
Citation
The 10th International Symposium on Mechanisms of Vasodilatation (MOVD 2009), Matsushima, Miyagi, Japan, 1-3 June 2009. In Journal of Vascular Research, 2009, v. 46 suppl. 1, p. 110, abstract no. P4-3 How to Cite?
AbstractRecent evidence suggests that extracellular signal-regulated kinase-1/2 (ERK 1/2) affect vascular tone. The present study examined the role of this enzyme in vascular control under physiological and pathological conditions. Using tissue bath technique, vascular responses were measured in terms of changes in isometric tension in aortic rings that were isolated from normotensive Wistar-Kyoto (WKY) rats and hypertensive spontaneously hypertensive rats (SHR) at different ages, 36-39 week old (adult group) and 72-75 week ROG DJHGJURXS ,QKLELWLRQRI(5. E\8 ȝ0 UHGXFHGSKHQ\OHSKULQH induced contraction in aortae. The inhibitory effect of U0126 on contraction was smaller in aged WKY rats compared to the other groups. While U0126 did not affect relaxation WRDFHW\OFKROLQH ȝ0 LQDGXOW:.< UDWV LWHQKDQFHGDFHW\OFKROLQH LQGXFHGUHOD[DWLRQ in aged WKY rats and in adult and aged SHR. The enhanced relaxation was abolished by / 1$0( DQLWULFR[LGHV\QWKDVHLQKLELWRU ȝ0 LQ:.
DescriptionThis free access journal suppl. is Proceedings of the 10th International Symposium on Mechanisms of Vasodilatation 2009
Persistent Identifierhttp://hdl.handle.net/10722/62854
ISSN
2015 Impact Factor: 2.186
2015 SCImago Journal Rankings: 1.119

 

DC FieldValueLanguage
dc.contributor.authorLeung, SWSen_HK
dc.contributor.authorHo, YWen_HK
dc.contributor.authorMan, GSKen_HK
dc.contributor.authorLeung, GPHen_HK
dc.contributor.authorMan, RYKen_HK
dc.date.accessioned2010-07-13T04:10:39Z-
dc.date.available2010-07-13T04:10:39Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 10th International Symposium on Mechanisms of Vasodilatation (MOVD 2009), Matsushima, Miyagi, Japan, 1-3 June 2009. In Journal of Vascular Research, 2009, v. 46 suppl. 1, p. 110, abstract no. P4-3-
dc.identifier.issn1018-1172-
dc.identifier.urihttp://hdl.handle.net/10722/62854-
dc.descriptionThis free access journal suppl. is Proceedings of the 10th International Symposium on Mechanisms of Vasodilatation 2009-
dc.description.abstractRecent evidence suggests that extracellular signal-regulated kinase-1/2 (ERK 1/2) affect vascular tone. The present study examined the role of this enzyme in vascular control under physiological and pathological conditions. Using tissue bath technique, vascular responses were measured in terms of changes in isometric tension in aortic rings that were isolated from normotensive Wistar-Kyoto (WKY) rats and hypertensive spontaneously hypertensive rats (SHR) at different ages, 36-39 week old (adult group) and 72-75 week ROG DJHGJURXS ,QKLELWLRQRI(5. E\8 ȝ0 UHGXFHGSKHQ\OHSKULQH induced contraction in aortae. The inhibitory effect of U0126 on contraction was smaller in aged WKY rats compared to the other groups. While U0126 did not affect relaxation WRDFHW\OFKROLQH ȝ0 LQDGXOW:.< UDWV LWHQKDQFHGDFHW\OFKROLQH LQGXFHGUHOD[DWLRQ in aged WKY rats and in adult and aged SHR. The enhanced relaxation was abolished by / 1$0( DQLWULFR[LGHV\QWKDVHLQKLELWRU ȝ0 LQ:.<DQG6+5RIDOODJHJURXSV DQG UHGXFHGE\LQGRPHWKDFLQ DF\FORR[\JHQDVHLQKLELWRU ȝ0 LQDJHG:.< UDWV Therefore, our results indicate that ERK 1/2 contributes to the contraction induced by phenylephrine to a similar degree in adult rats. On the other hand, ERK 1/2 is activated in aged and hypertensive rats, leading to the suppression of nitric oxide-mediated relaxation. As such, ERK 1/2 appears to contribute to vascular dysfunction in aging and hypertension.-
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/JVR-
dc.relation.ispartofJournal of Vascular Research-
dc.titleRole of extracellular signal-related kinases in the pathophysiology of vascular dysfunction in aging and hypertensionen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLeung, SWS: swsleung@hku.hken_HK
dc.identifier.emailMan, GSK: gskman@HKUSUA.hku.hken_HK
dc.identifier.emailLeung, GPH: gphleung@hku.hken_HK
dc.identifier.emailMan, RYK: rykman@hku.hken_HK
dc.identifier.authorityLeung, SWS=rp00235en_HK
dc.identifier.authorityLeung, GPH=rp00234en_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1159/000222318-
dc.identifier.hkuros156234en_HK
dc.identifier.hkuros157526-
dc.identifier.volume46-
dc.identifier.issuesuppl. 1-
dc.identifier.spage110, abstract no. P4-3-
dc.identifier.epage110, abstract no. P4-3-
dc.customcontrol.immutablesml 170110 amended-

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