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Conference Paper: Contractile Response To Hypoxia In The Porcine Coronary Artery

TitleContractile Response To Hypoxia In The Porcine Coronary Artery
Authors
Issue Date2008
PublisherHong Kong College of Cardiology. The Journal's web site is located at http://www.hkcchk.com/journals.php#3
Citation
The 12th Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, Hong Kong, 13-14 December 2008. In Journal of the Hong Kong College of Cardiology, 2008, v. 16 n. 2, p. 57, abstract no. OC1 How to Cite?
AbstractThe contractile response to hypoxia has been studied in the lung, and is termed hypoxic pulmonary vasoconstriction. However this response is also observed in coronary arteries. The present study investigated the mechanism underlying this contractile response in isolated porcine coronary arteries. Isometric tension was measured in rings with or without endothelium. In quiescent preparations, the contractile response to hypoxia was only observed in rings with endothelium and was abolished by indomethacin and terutroban, which shows the involvement of cyclooxygenase products and TP receptor activation, respectively, in this phenomenon. In contracted preparations, the hypoxic response was also endothelium-dependent, but was abolished by L-NAME and ODQ, suggesting the involvement of cyclic GMP. Assay of the cyclic GMP content showed no change upon exposure to hypoxia in preparations with and without endothelium. These experiments suggest that these hypoxic coronary contractions depend on more than one signaling pathway.
DescriptionThis journal issue is proceedings of ICSM 2008
Oral Communications
Persistent Identifierhttp://hdl.handle.net/10722/62832
ISSN
2015 SCImago Journal Rankings: 0.102

 

DC FieldValueLanguage
dc.contributor.authorChan, CKYen_HK
dc.contributor.authorMak, JCWen_HK
dc.contributor.authorMan, RYKen_HK
dc.contributor.authorVanhoutte, PMGRen_HK
dc.date.accessioned2010-07-13T04:10:11Z-
dc.date.available2010-07-13T04:10:11Z-
dc.date.issued2008en_HK
dc.identifier.citationThe 12th Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, Hong Kong, 13-14 December 2008. In Journal of the Hong Kong College of Cardiology, 2008, v. 16 n. 2, p. 57, abstract no. OC1-
dc.identifier.issn1027-7811-
dc.identifier.urihttp://hdl.handle.net/10722/62832-
dc.descriptionThis journal issue is proceedings of ICSM 2008en_HK
dc.descriptionOral Communications-
dc.description.abstractThe contractile response to hypoxia has been studied in the lung, and is termed hypoxic pulmonary vasoconstriction. However this response is also observed in coronary arteries. The present study investigated the mechanism underlying this contractile response in isolated porcine coronary arteries. Isometric tension was measured in rings with or without endothelium. In quiescent preparations, the contractile response to hypoxia was only observed in rings with endothelium and was abolished by indomethacin and terutroban, which shows the involvement of cyclooxygenase products and TP receptor activation, respectively, in this phenomenon. In contracted preparations, the hypoxic response was also endothelium-dependent, but was abolished by L-NAME and ODQ, suggesting the involvement of cyclic GMP. Assay of the cyclic GMP content showed no change upon exposure to hypoxia in preparations with and without endothelium. These experiments suggest that these hypoxic coronary contractions depend on more than one signaling pathway.-
dc.languageengen_HK
dc.publisherHong Kong College of Cardiology. The Journal's web site is located at http://www.hkcchk.com/journals.php#3-
dc.relation.ispartofJournal of the Hong Kong College of Cardiology-
dc.titleContractile Response To Hypoxia In The Porcine Coronary Arteryen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, CKY: chancalvink@gmail.comen_HK
dc.identifier.emailMak, JCW: judymak@hku.hken_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.emailVanhoutte, PMGR: vanhoutt@hku.hken_HK
dc.identifier.authorityMak, JCW=rp00352en_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.identifier.authorityVanhoutte, PMGR=rp00238en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros166883en_HK
dc.identifier.volume16-
dc.identifier.issue2-
dc.identifier.spage57, abstract no. OC1-
dc.identifier.epage57, abstract no. OC1-
dc.publisher.placeHong Kong-

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