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Conference Paper: Micro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in osteoporotic goats

TitleMicro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in osteoporotic goats
Authors
Issue Date2008
PublisherElsevier Inc.
Citation
International Conference on Osteoporosis and Bone Research 2008 Beijing, China, 22–25 October 2008. In Bone, 2008, v. 43 n. S1, p. S47 How to Cite?
AbstractIntroduction: Strontium (Sr) is one of the most exciting concepts in the field of osteoporosis treatment by concomitantly inhibiting bone resorption and enhancing bone formation. Previously, we developed a Sr fortified calcium (Ca) compound. In this study, the micro-architecture and nano-mechanical property of lumbar vertebra were evaluated after administration of this Sr compound in osteoporotic goats. Methods: 18 aged goats were ovariectomized to establish an osteoporosis model. One (1) year post-ovariectomy, animals were randomly assigned to four (4) different groups and treated as follows: control group (3 goats); normal Ca diet (Ca), normal Ca plus low Sr diet (Ca + LSr) and normal Ca plus high Sr diet (Ca + HSr) (5 goats per group) respectively. After treating daily for 16 weeks, trabecular micro-architectural parameters from μCT were quantified. The biomechanical properties of single trabeculae were determined by nanoindentation. Compressive test were performed on the whole lumbar spine body (L4) by means of a materials testing system (MTS). Results and Discussion: Ca alone and Ca + HSr treatment increased trabecular bone volume (BV/TV) by 3.53% and 5.39%, respectively. BV/TV significantly increased 8.59% in Ca + 24Sr group primarily by increasing trabecular thickness (Tb.Th⁎). The increase in apparent BMD and BV/TV in Ca combined with Sr treatment seemed to result from increased bone formation rate. Elastic modulus (E) of single trabeculaes was not changed in Sr combined with Ca treatment despite a slight decrease in hardness (H). In the treatment with Sr administration, a considerably higher E/H ratio, without statistical significance, was observed. The result might provide evidences for fracture risks reduction as observed in postmenopausal women after treatment with Sr containing drug. The compression test indicated an increase by 22.19% (p = 0.099) and 4.26% (p = 0.702) in Ca + LSr and Ca + HSr treatment groups, respectively. In the Ca alone treatment group, the maximal load was comparable to the mean value noted in the control animals (p = 0.936). A very slight modification of bone stiffness was observed between these groups. The observed trend for increase in the bone strength under the effect of Sr treatment was not statistically significant but this may be due, in part, to the relatively small number of animals studied. Conclusion: Combination of Sr and Ca treatment significantly increased BV/TV, primarily by increasing Tb.Th⁎. Ironically, Sr and Ca treatment did not significantly affect the mechanical property of either single trabecula or the whole lumbar vertebra body. Acknowledgement: Hong Kong ITF fund GHP/009/06 and RGC HKU7147/07E.
Persistent Identifierhttp://hdl.handle.net/10722/62615
ISSN
2015 Impact Factor: 3.736
2015 SCImago Journal Rankings: 1.752

 

DC FieldValueLanguage
dc.contributor.authorLi, Zen_HK
dc.contributor.authorLu, WWen_HK
dc.contributor.authorChiu, PKYen_HK
dc.contributor.authorLam, RWMen_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorFang, Den_HK
dc.contributor.authorLeong, JCYen_HK
dc.contributor.authorLuk, KDKen_HK
dc.date.accessioned2010-07-13T04:05:07Z-
dc.date.available2010-07-13T04:05:07Z-
dc.date.issued2008en_HK
dc.identifier.citationInternational Conference on Osteoporosis and Bone Research 2008 Beijing, China, 22–25 October 2008. In Bone, 2008, v. 43 n. S1, p. S47en_HK
dc.identifier.issn8756-3282en_HK
dc.identifier.urihttp://hdl.handle.net/10722/62615-
dc.description.abstractIntroduction: Strontium (Sr) is one of the most exciting concepts in the field of osteoporosis treatment by concomitantly inhibiting bone resorption and enhancing bone formation. Previously, we developed a Sr fortified calcium (Ca) compound. In this study, the micro-architecture and nano-mechanical property of lumbar vertebra were evaluated after administration of this Sr compound in osteoporotic goats. Methods: 18 aged goats were ovariectomized to establish an osteoporosis model. One (1) year post-ovariectomy, animals were randomly assigned to four (4) different groups and treated as follows: control group (3 goats); normal Ca diet (Ca), normal Ca plus low Sr diet (Ca + LSr) and normal Ca plus high Sr diet (Ca + HSr) (5 goats per group) respectively. After treating daily for 16 weeks, trabecular micro-architectural parameters from μCT were quantified. The biomechanical properties of single trabeculae were determined by nanoindentation. Compressive test were performed on the whole lumbar spine body (L4) by means of a materials testing system (MTS). Results and Discussion: Ca alone and Ca + HSr treatment increased trabecular bone volume (BV/TV) by 3.53% and 5.39%, respectively. BV/TV significantly increased 8.59% in Ca + 24Sr group primarily by increasing trabecular thickness (Tb.Th⁎). The increase in apparent BMD and BV/TV in Ca combined with Sr treatment seemed to result from increased bone formation rate. Elastic modulus (E) of single trabeculaes was not changed in Sr combined with Ca treatment despite a slight decrease in hardness (H). In the treatment with Sr administration, a considerably higher E/H ratio, without statistical significance, was observed. The result might provide evidences for fracture risks reduction as observed in postmenopausal women after treatment with Sr containing drug. The compression test indicated an increase by 22.19% (p = 0.099) and 4.26% (p = 0.702) in Ca + LSr and Ca + HSr treatment groups, respectively. In the Ca alone treatment group, the maximal load was comparable to the mean value noted in the control animals (p = 0.936). A very slight modification of bone stiffness was observed between these groups. The observed trend for increase in the bone strength under the effect of Sr treatment was not statistically significant but this may be due, in part, to the relatively small number of animals studied. Conclusion: Combination of Sr and Ca treatment significantly increased BV/TV, primarily by increasing Tb.Th⁎. Ironically, Sr and Ca treatment did not significantly affect the mechanical property of either single trabecula or the whole lumbar vertebra body. Acknowledgement: Hong Kong ITF fund GHP/009/06 and RGC HKU7147/07E.-
dc.languageengen_HK
dc.publisherElsevier Inc.en_HK
dc.relation.ispartofBone-
dc.titleMicro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in osteoporotic goatsen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=8756-3282&volume=43&spage=47&epage=&date=2008&atitle=Micro-architectural+and+Nano-mechanical+Properties+of+Trabecular+Bone+with+Strontium+Treatment+in+Osteoporotic+Goatsen_HK
dc.identifier.emailLi, Z: zhyli@graduate.hku.hken_HK
dc.identifier.emailLu, WW: wwlu@hkusua.hku.hken_HK
dc.identifier.emailChiu, PKY: pkychiu@hkucc.hku.hken_HK
dc.identifier.emailLam, RWM: h9603582@graduate.hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.emailFang, D: hrmodaf@HKUCC.hku.hken_HK
dc.identifier.emailLeong, JCY: hrmolcy@hkucc.hku.hken_HK
dc.identifier.emailLuk, KDK: hrmoldk@hkucc.hku.hken_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.identifier.authorityChiu, PKY=rp00379en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.bone.2008.08.028-
dc.identifier.hkuros158929en_HK

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