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Conference Paper: Strontium Fortified Calcium Compound Stimulates Osteogenic Factors Expression and New Bone Formation in Large Animal Model

TitleStrontium Fortified Calcium Compound Stimulates Osteogenic Factors Expression and New Bone Formation in Large Animal Model
Authors
Issue Date2008
PublisherInternational Society of Orthopaedic Surgery and Traumatology.
Citation
SICOT/SIROT 2008 XXIV Triennial World Congress, Hong Kong, 24-28 August 2008, p. abstract no. 17436 How to Cite?
AbstractINTRODUCTION: Strontium is one of the most exciting concepts in the field of osteoporosis by concomitantly inhibiting bone resorption and enhancing bone formation. We hypothesized that, with the supplementation of a novel strontium fortified calcium compound, calcium will supply nutrition for bone while strontium will display synergistic effects for enhancing bone formation activity. METHODS: 18 ovariectomized goats were divided into four groups: group 1 (3 goats) control; group 2, 3 and 4 (5 per group) were treated daily with 100Ca, 100Ca+24Sr, 100Ca+40Sr mg/kg orally for 16 weeks, respectively. Strontium and calcium contents in serum and bone were determined. BMD of the lumbar vertebrae was measured by DXA. MRNA was isolated from bone matrix and evaluated by RT-PCR to determine the transcription activities of key osteogenic factors. RESULTS: Combination of Sr and Ca treatment significantly increased Sr concentration without changing in Ca concentration. BMD of group 2 and 3 slightly increased from 0.160±0.005 to 0.163±0.013 and determine the transcription activities of key osteogenic factors. RESULTS: Combination of Sr and Ca treatment significantly increased Sr concentration without changing in Ca concentration. BMD of group 2 and 3 slightly increased from 0.160±0.005 to 0.163±0.013 and 0.170±0.015gms/cm², respectively. BMD of group 4 was significantly increased by 9.4% (p<0.05). Calcium significantly depressed TNF- a expression (p<0.05). IGF-I and Runx-2 expression increased, while TNF-a expression decreased in group 3 and 4. However, a considerable increase of Runx-2 and decrease of TNF-a were only found in group 4. CONCLUSION: An increased BMD indicates that strontium combined with calcium stimulated bone formation. Increased IGF-I, Runx-2 and decreased TNF-a expression confirm the anabolic and antiresorptive activity of strontium on bone.
DescriptionSession: SIROT - Osteoporosis
Poster presentation
Persistent Identifierhttp://hdl.handle.net/10722/62563

 

DC FieldValueLanguage
dc.contributor.authorLu, WWen_HK
dc.contributor.authorLi, Zen_HK
dc.contributor.authorChiu, PKYen_HK
dc.contributor.authorLam, RWMen_HK
dc.contributor.authorWong, CTen_HK
dc.contributor.authorFang, Den_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorLeong, JCYen_HK
dc.contributor.authorLuk, KDKen_HK
dc.date.accessioned2010-07-13T04:04:01Z-
dc.date.available2010-07-13T04:04:01Z-
dc.date.issued2008en_HK
dc.identifier.citationSICOT/SIROT 2008 XXIV Triennial World Congress, Hong Kong, 24-28 August 2008, p. abstract no. 17436-
dc.identifier.urihttp://hdl.handle.net/10722/62563-
dc.descriptionSession: SIROT - Osteoporosisen_HK
dc.descriptionPoster presentation-
dc.description.abstractINTRODUCTION: Strontium is one of the most exciting concepts in the field of osteoporosis by concomitantly inhibiting bone resorption and enhancing bone formation. We hypothesized that, with the supplementation of a novel strontium fortified calcium compound, calcium will supply nutrition for bone while strontium will display synergistic effects for enhancing bone formation activity. METHODS: 18 ovariectomized goats were divided into four groups: group 1 (3 goats) control; group 2, 3 and 4 (5 per group) were treated daily with 100Ca, 100Ca+24Sr, 100Ca+40Sr mg/kg orally for 16 weeks, respectively. Strontium and calcium contents in serum and bone were determined. BMD of the lumbar vertebrae was measured by DXA. MRNA was isolated from bone matrix and evaluated by RT-PCR to determine the transcription activities of key osteogenic factors. RESULTS: Combination of Sr and Ca treatment significantly increased Sr concentration without changing in Ca concentration. BMD of group 2 and 3 slightly increased from 0.160±0.005 to 0.163±0.013 and determine the transcription activities of key osteogenic factors. RESULTS: Combination of Sr and Ca treatment significantly increased Sr concentration without changing in Ca concentration. BMD of group 2 and 3 slightly increased from 0.160±0.005 to 0.163±0.013 and 0.170±0.015gms/cm², respectively. BMD of group 4 was significantly increased by 9.4% (p<0.05). Calcium significantly depressed TNF- a expression (p<0.05). IGF-I and Runx-2 expression increased, while TNF-a expression decreased in group 3 and 4. However, a considerable increase of Runx-2 and decrease of TNF-a were only found in group 4. CONCLUSION: An increased BMD indicates that strontium combined with calcium stimulated bone formation. Increased IGF-I, Runx-2 and decreased TNF-a expression confirm the anabolic and antiresorptive activity of strontium on bone.-
dc.languageengen_HK
dc.publisherInternational Society of Orthopaedic Surgery and Traumatology.-
dc.relation.ispartofSICOT/SIROT World Congress-
dc.titleStrontium Fortified Calcium Compound Stimulates Osteogenic Factors Expression and New Bone Formation in Large Animal Modelen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailLu, WW: wwlu@hkusua.hku.hken_HK
dc.identifier.emailChiu, PKY: pkychiu@hkucc.hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.emailLuk, KDK: hrmoldk@hku.hken_HK
dc.identifier.authorityLu, WW=rp00411en_HK
dc.identifier.authorityChiu, PKY=rp00379en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.hkuros166196en_HK
dc.identifier.hkuros162573-
dc.identifier.spageabstract no. 17436-
dc.identifier.epageabstract no. 17436-
dc.publisher.placeFrance-

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