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Conference Paper: A SNP in IFNGR1 promoter is correlated to the susceptibility to chronic HBV infection in Chinese population

TitleA SNP in IFNGR1 promoter is correlated to the susceptibility to chronic HBV infection in Chinese population
Authors
Issue Date2009
PublisherElsevier Ltd.
Citation
The 19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2009), Helsinki, Finland, 16-19 May 2009. In Clinical Microbiology and Infection, 2009, v. 15 suppl. 4, p. S176, abstract no. P725 How to Cite?
AbstractOBJECTIVES: The antiviral mechanism stimulated by interferon-gamma is found to be crucial for clearance of hepatitis B virus (HBV) in vivo. The antiviral signaling transduction is triggered by the specific binding between interferon-gamma and its receptor IFNGR1 (interferongamma receptor 1). Interferon-gamma signaling transduction pathway is directly controlled by the IFNGR1 expression level. In our study, single nucleotide polymorphisms (SNPs) in the IFNGR1 gene and the correlation between the SNPs and susceptibility to chronic HBV in Chinese were investigated. METHODS: Blood samples of 983 Chinese, including 361 chronic hepatitis B patients, 366 healthy individuals, and 256 hepatitis B spontaneously recovered patients, were collected. Seven SNPs (−611A/G, −56C/T, 40G/A, 95C/T, 130A/G, 20685A/G, 21227T/C) in IFNGR1 gene were identified by restriction fragment-length polymorphism (RFLP) assays. The transcription levels of different SNPs variants were compared by luciferase assays. RESULTS: −56C and −56T allele were found to be correlated to HBV clearance and persistence. In luciferase assays, the transcription level of IFNGR1 promoter with the −56C is significantly higher than that with −56T. CONCLUSION: −56C/T SNP in IFNGR1 promoter region is associated with susceptibility to chronic HBV in Chinese population.
DescriptionThis journal suppl. entitled: Abstracts of the 19th ECCMID (European Congress of Clinical Microbiology and Infectious Diseases). Helsinki, Finland. May 16-19, 2009.
Posters: no. P725
Persistent Identifierhttp://hdl.handle.net/10722/62478
ISSN
2015 Impact Factor: 4.575
2015 SCImago Journal Rankings: 2.530

 

DC FieldValueLanguage
dc.contributor.authorZeng, Yen_HK
dc.contributor.authorZhou, Jen_HK
dc.contributor.authorChen, Den_HK
dc.contributor.authorPoon, VKMen_HK
dc.contributor.authorNg, Fen_HK
dc.contributor.authorYuen, KYen_HK
dc.contributor.authorZheng, Ben_HK
dc.date.accessioned2010-07-13T04:02:10Z-
dc.date.available2010-07-13T04:02:10Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2009), Helsinki, Finland, 16-19 May 2009. In Clinical Microbiology and Infection, 2009, v. 15 suppl. 4, p. S176, abstract no. P725-
dc.identifier.issn1198-743X-
dc.identifier.urihttp://hdl.handle.net/10722/62478-
dc.descriptionThis journal suppl. entitled: Abstracts of the 19th ECCMID (European Congress of Clinical Microbiology and Infectious Diseases). Helsinki, Finland. May 16-19, 2009.en_HK
dc.descriptionPosters: no. P725-
dc.description.abstractOBJECTIVES: The antiviral mechanism stimulated by interferon-gamma is found to be crucial for clearance of hepatitis B virus (HBV) in vivo. The antiviral signaling transduction is triggered by the specific binding between interferon-gamma and its receptor IFNGR1 (interferongamma receptor 1). Interferon-gamma signaling transduction pathway is directly controlled by the IFNGR1 expression level. In our study, single nucleotide polymorphisms (SNPs) in the IFNGR1 gene and the correlation between the SNPs and susceptibility to chronic HBV in Chinese were investigated. METHODS: Blood samples of 983 Chinese, including 361 chronic hepatitis B patients, 366 healthy individuals, and 256 hepatitis B spontaneously recovered patients, were collected. Seven SNPs (−611A/G, −56C/T, 40G/A, 95C/T, 130A/G, 20685A/G, 21227T/C) in IFNGR1 gene were identified by restriction fragment-length polymorphism (RFLP) assays. The transcription levels of different SNPs variants were compared by luciferase assays. RESULTS: −56C and −56T allele were found to be correlated to HBV clearance and persistence. In luciferase assays, the transcription level of IFNGR1 promoter with the −56C is significantly higher than that with −56T. CONCLUSION: −56C/T SNP in IFNGR1 promoter region is associated with susceptibility to chronic HBV in Chinese population.-
dc.languageengen_HK
dc.publisherElsevier Ltd.-
dc.relation.ispartofClinical Microbiology and Infection-
dc.titleA SNP in IFNGR1 promoter is correlated to the susceptibility to chronic HBV infection in Chinese populationen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailPoon, VKM: vincent.poonkm@gmail.comen_HK
dc.identifier.emailNg, F: fng@HKUCC-COM.hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.emailZheng, B: bzheng@hkucc.hku.hken_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.identifier.authorityZheng, B=rp00353en_HK
dc.identifier.doi10.1111/j.1469-0691.2009.02858.x-
dc.identifier.pmid19519682-
dc.identifier.hkuros156509en_HK
dc.identifier.volume15-
dc.identifier.issuesuppl. 4-
dc.identifier.spageS176, abstract no. P725-
dc.identifier.epageS176, abstract no. P725-

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