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- Publisher Website: 10.1111/j.1469-0691.2009.02858.x
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Conference Paper: A SNP in IFNGR1 promoter is correlated to the susceptibility to chronic HBV infection in Chinese population
Title | A SNP in IFNGR1 promoter is correlated to the susceptibility to chronic HBV infection in Chinese population |
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Authors | |
Issue Date | 2009 |
Publisher | Elsevier Ltd. |
Citation | The 19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2009), Helsinki, Finland, 16-19 May 2009. In Clinical Microbiology and Infection, 2009, v. 15 suppl. 4, p. S176, abstract no. P725 How to Cite? |
Abstract | OBJECTIVES: The antiviral mechanism stimulated by interferon-gamma is found to be crucial for clearance of hepatitis B virus (HBV) in vivo. The antiviral signaling transduction is triggered by the specific binding between interferon-gamma and its receptor IFNGR1 (interferongamma receptor 1). Interferon-gamma signaling transduction pathway is directly controlled by the IFNGR1 expression level. In our study, single nucleotide polymorphisms (SNPs) in the IFNGR1 gene and the correlation between the SNPs and susceptibility to chronic HBV in Chinese were investigated. METHODS: Blood samples of 983 Chinese, including 361 chronic hepatitis B patients, 366 healthy individuals, and 256 hepatitis B spontaneously recovered patients, were collected. Seven SNPs (−611A/G, −56C/T, 40G/A, 95C/T, 130A/G, 20685A/G, 21227T/C) in IFNGR1 gene were identified by restriction fragment-length polymorphism (RFLP) assays. The transcription levels of different SNPs variants were compared by luciferase assays. RESULTS: −56C and −56T allele were found to be correlated to HBV clearance and persistence. In luciferase assays, the transcription level of IFNGR1 promoter with the −56C is significantly higher than that with −56T. CONCLUSION: −56C/T SNP in IFNGR1 promoter region is associated with susceptibility to chronic HBV in Chinese population. |
Description | This journal suppl. entitled: Abstracts of the 19th ECCMID (European Congress of Clinical Microbiology and Infectious Diseases). Helsinki, Finland. May 16-19, 2009. Posters: no. P725 |
Persistent Identifier | http://hdl.handle.net/10722/62478 |
ISSN | 2023 Impact Factor: 10.9 2023 SCImago Journal Rankings: 3.089 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zeng, Y | en_HK |
dc.contributor.author | Zhou, J | en_HK |
dc.contributor.author | Chen, D | en_HK |
dc.contributor.author | Poon, VKM | en_HK |
dc.contributor.author | Ng, F | en_HK |
dc.contributor.author | Yuen, KY | en_HK |
dc.contributor.author | Zheng, B | en_HK |
dc.date.accessioned | 2010-07-13T04:02:10Z | - |
dc.date.available | 2010-07-13T04:02:10Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | The 19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2009), Helsinki, Finland, 16-19 May 2009. In Clinical Microbiology and Infection, 2009, v. 15 suppl. 4, p. S176, abstract no. P725 | - |
dc.identifier.issn | 1198-743X | - |
dc.identifier.uri | http://hdl.handle.net/10722/62478 | - |
dc.description | This journal suppl. entitled: Abstracts of the 19th ECCMID (European Congress of Clinical Microbiology and Infectious Diseases). Helsinki, Finland. May 16-19, 2009. | en_HK |
dc.description | Posters: no. P725 | - |
dc.description.abstract | OBJECTIVES: The antiviral mechanism stimulated by interferon-gamma is found to be crucial for clearance of hepatitis B virus (HBV) in vivo. The antiviral signaling transduction is triggered by the specific binding between interferon-gamma and its receptor IFNGR1 (interferongamma receptor 1). Interferon-gamma signaling transduction pathway is directly controlled by the IFNGR1 expression level. In our study, single nucleotide polymorphisms (SNPs) in the IFNGR1 gene and the correlation between the SNPs and susceptibility to chronic HBV in Chinese were investigated. METHODS: Blood samples of 983 Chinese, including 361 chronic hepatitis B patients, 366 healthy individuals, and 256 hepatitis B spontaneously recovered patients, were collected. Seven SNPs (−611A/G, −56C/T, 40G/A, 95C/T, 130A/G, 20685A/G, 21227T/C) in IFNGR1 gene were identified by restriction fragment-length polymorphism (RFLP) assays. The transcription levels of different SNPs variants were compared by luciferase assays. RESULTS: −56C and −56T allele were found to be correlated to HBV clearance and persistence. In luciferase assays, the transcription level of IFNGR1 promoter with the −56C is significantly higher than that with −56T. CONCLUSION: −56C/T SNP in IFNGR1 promoter region is associated with susceptibility to chronic HBV in Chinese population. | - |
dc.language | eng | en_HK |
dc.publisher | Elsevier Ltd. | - |
dc.relation.ispartof | Clinical Microbiology and Infection | - |
dc.title | A SNP in IFNGR1 promoter is correlated to the susceptibility to chronic HBV infection in Chinese population | en_HK |
dc.type | Conference_Paper | en_HK |
dc.identifier.email | Poon, VKM: vincent.poonkm@gmail.com | en_HK |
dc.identifier.email | Ng, F: fng@HKUCC-COM.hku.hk | en_HK |
dc.identifier.email | Yuen, KY: kyyuen@hkucc.hku.hk | en_HK |
dc.identifier.email | Zheng, B: bzheng@hkucc.hku.hk | en_HK |
dc.identifier.authority | Yuen, KY=rp00366 | en_HK |
dc.identifier.authority | Zheng, B=rp00353 | en_HK |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1111/j.1469-0691.2009.02858.x | - |
dc.identifier.pmid | 19519682 | - |
dc.identifier.hkuros | 156509 | en_HK |
dc.identifier.volume | 15 | - |
dc.identifier.issue | suppl. 4 | - |
dc.identifier.spage | S176, abstract no. P725 | - |
dc.identifier.epage | S176, abstract no. P725 | - |
dc.identifier.issnl | 1198-743X | - |