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Conference Paper: FRAX™ and the Assessment of Ten-Year Fracture Probability in Hong Kong Southern Chinese According to Age and BMD Femoral Neck T-Scores

TitleFRAX™ and the Assessment of Ten-Year Fracture Probability in Hong Kong Southern Chinese According to Age and BMD Femoral Neck T-Scores
Authors
Issue Date2008
PublisherAmerican Society for Bone and Mineral Research
Citation
30th Annual Meeting of the American Society for Bone and Mineral Research, Montreal, Canada, 12-16 September 2008, Presentation no. Su264 How to Cite?
AbstractAt present, studies using Asian subjects to estimate the probability of osteoporotic fracture remain sparse. Although the WHO algorithms (FRAX™) risk assessment tool has data for Chinese population, the absolute fracture risk estimated for Chinese living in mainland China may not be applicable to southern Chinese in Hong Kong because of differences in lifestyle habits and subject characteristics. The objective of this study was to estimate the 10-year probability of osteoporotic fracture in Hong Kong southern Chinese according to age and BMD T-score at the femoral neck based on the methodology of FRAXTM risk assessment tool calibrated to the epidemiology of Hong Kong. Fracture data was obtained from the Clinical Data Analysis Reporting System (CDAS) of the Hospital Authority of Hong Kong while population size and death rates were taken from the Hong Kong Government Census and Statistics Department. Fracture probability was calculated using the cut-off values for T-scores derived from the NHANES III data for Caucasian women aged 20-29 years for BMD at the femoral neck. We found that the 10-year probability of osteoporotic fracture in Hong Kong southern Chinese men and women increased markedly with increasing age and decreasing femoral neck BMD T-score. Furthermore, the results showed that the 10-year absolute fracture risk for Hong Kong southern Chinese was substantially higher than the mainland Chinese and was comparable to Caucasians in other developed countries like USA and UK. Based on this evidence and until we have Hong Kong southern Chinese population-specific information, we recommend the application of the Caucasian risk profile to calculate the absolute fracture risk for Hong Kong southern Chinese subjects.
Persistent Identifierhttp://hdl.handle.net/10722/62406

 

DC FieldValueLanguage
dc.contributor.authorTsang, SWYen_HK
dc.contributor.authorKung, AWCen_HK
dc.contributor.authorKanis, JAen_HK
dc.contributor.authorJohansson, Hen_HK
dc.contributor.authorOden, Aen_HK
dc.date.accessioned2010-07-13T04:00:34Z-
dc.date.available2010-07-13T04:00:34Z-
dc.date.issued2008en_HK
dc.identifier.citation30th Annual Meeting of the American Society for Bone and Mineral Research, Montreal, Canada, 12-16 September 2008, Presentation no. Su264-
dc.identifier.urihttp://hdl.handle.net/10722/62406-
dc.description.abstractAt present, studies using Asian subjects to estimate the probability of osteoporotic fracture remain sparse. Although the WHO algorithms (FRAX™) risk assessment tool has data for Chinese population, the absolute fracture risk estimated for Chinese living in mainland China may not be applicable to southern Chinese in Hong Kong because of differences in lifestyle habits and subject characteristics. The objective of this study was to estimate the 10-year probability of osteoporotic fracture in Hong Kong southern Chinese according to age and BMD T-score at the femoral neck based on the methodology of FRAXTM risk assessment tool calibrated to the epidemiology of Hong Kong. Fracture data was obtained from the Clinical Data Analysis Reporting System (CDAS) of the Hospital Authority of Hong Kong while population size and death rates were taken from the Hong Kong Government Census and Statistics Department. Fracture probability was calculated using the cut-off values for T-scores derived from the NHANES III data for Caucasian women aged 20-29 years for BMD at the femoral neck. We found that the 10-year probability of osteoporotic fracture in Hong Kong southern Chinese men and women increased markedly with increasing age and decreasing femoral neck BMD T-score. Furthermore, the results showed that the 10-year absolute fracture risk for Hong Kong southern Chinese was substantially higher than the mainland Chinese and was comparable to Caucasians in other developed countries like USA and UK. Based on this evidence and until we have Hong Kong southern Chinese population-specific information, we recommend the application of the Caucasian risk profile to calculate the absolute fracture risk for Hong Kong southern Chinese subjects.-
dc.languageengen_HK
dc.publisherAmerican Society for Bone and Mineral Research-
dc.relation.ispartofAmerican Society for Bone and Mineral Research Annual Meeting-
dc.titleFRAX™ and the Assessment of Ten-Year Fracture Probability in Hong Kong Southern Chinese According to Age and BMD Femoral Neck T-Scoresen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailTsang, SWY: tsangwanyin@yahoo.comen_HK
dc.identifier.emailKung, AWC: awckung@hku.hken_HK
dc.identifier.authorityKung, AWC=rp00368en_HK
dc.identifier.hkuros147548en_HK

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