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Conference Paper: Interim analysis of the natural history of chronic hepatitis C genotype 1 and 6

TitleInterim analysis of the natural history of chronic hepatitis C genotype 1 and 6
Authors
Issue Date2008
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/
Citation
The 59th Annual Meeting of the American Association for the Study of Liver Diseases, San Francisco, CA, 31 October - 4 November 2008, In Hepatology, 2008, v. 48 n. Suppl 1, p. 1102A How to Cite?
AbstractBACKGROUND: Data on the natural history of Chronic Hepati-tis C (HCV) genotype 6 is lacking. We compared the naturalhistory of 141 patients with HCV genotype 1 (median age: 50)and 80 patients with HCV genotype 6 (median age: 47.5).Baseline demographic data including gender ratio, route oftransmission, liver biochemistry, serial alanine aminotransferase(ALT) levels and HCV-RNA levels, as well as the rate of HCV-related complications were analyzed. RESULTS: 72.3% ofgenotype 1 patients were infected through blood transfusion,8.5% from intravenous drug addiction, compared with 56.2%and 28.8% for genotype 6 patients (p<0.05). There were nodifferences in the baseline liver biochemistry in terms of ALT,albumin, bilirubin, alpha-fetoprotein (AFP) and HCV-RNAbetween both groups (p>0.05). Comparison of the proportionof normal and abnormal ALT levels within both groups showedno statistical difference (p=0.215). There was also no differ-ence in the cumulative risk of development of cirrhotic compli-cations and hepatocellular carcinoma between both groups(p=0.468). CONCLUSION: HCV genotype 1 patients werelargely infected through blood transfusion, while a statisticallylarger proportion of genotype 6 patients were intravenous drugaddicts. Both genotypes share a similar course of natural his-tory.
Persistent Identifierhttp://hdl.handle.net/10722/62346
ISSN
2014 Impact Factor: 11.055
2014 SCImago Journal Rankings: 4.310

 

DC FieldValueLanguage
dc.contributor.authorSeto, WKW-
dc.contributor.authorLai, CL-
dc.contributor.authorFung, JYY-
dc.contributor.authorYoung, JLP-
dc.contributor.authorYuen, JCH-
dc.contributor.authorWong, DKH-
dc.contributor.authorYuen, RMF-
dc.date.accessioned2010-07-13T03:59:17Z-
dc.date.available2010-07-13T03:59:17Z-
dc.date.issued2008-
dc.identifier.citationThe 59th Annual Meeting of the American Association for the Study of Liver Diseases, San Francisco, CA, 31 October - 4 November 2008, In Hepatology, 2008, v. 48 n. Suppl 1, p. 1102A-
dc.identifier.issn0270-9139-
dc.identifier.urihttp://hdl.handle.net/10722/62346-
dc.description.abstractBACKGROUND: Data on the natural history of Chronic Hepati-tis C (HCV) genotype 6 is lacking. We compared the naturalhistory of 141 patients with HCV genotype 1 (median age: 50)and 80 patients with HCV genotype 6 (median age: 47.5).Baseline demographic data including gender ratio, route oftransmission, liver biochemistry, serial alanine aminotransferase(ALT) levels and HCV-RNA levels, as well as the rate of HCV-related complications were analyzed. RESULTS: 72.3% ofgenotype 1 patients were infected through blood transfusion,8.5% from intravenous drug addiction, compared with 56.2%and 28.8% for genotype 6 patients (p<0.05). There were nodifferences in the baseline liver biochemistry in terms of ALT,albumin, bilirubin, alpha-fetoprotein (AFP) and HCV-RNAbetween both groups (p>0.05). Comparison of the proportionof normal and abnormal ALT levels within both groups showedno statistical difference (p=0.215). There was also no differ-ence in the cumulative risk of development of cirrhotic compli-cations and hepatocellular carcinoma between both groups(p=0.468). CONCLUSION: HCV genotype 1 patients werelargely infected through blood transfusion, while a statisticallylarger proportion of genotype 6 patients were intravenous drugaddicts. Both genotypes share a similar course of natural his-tory.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/-
dc.relation.ispartofHepatology-
dc.rightsHepatology. Copyright © John Wiley & Sons, Inc.-
dc.rightsSpecial Statement for Preprint only Before publication: 'This is a preprint of an article accepted for publication in [The Journal of Pathology] Copyright © ([year]) ([Pathological Society of Great Britain and Ireland])'. After publication: the preprint notice should be amended to follows: 'This is a preprint of an article published in [include the complete citation information for the final version of the Contribution as published in the print edition of the Journal]' For Cochrane Library/ Cochrane Database of Systematic Reviews, add statement & acknowledgement : ‘This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 20XX, Issue X. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.’ Please include reference to the Review and hyperlink to the original version using the following format e.g. Authors. Title of Review. Cochrane Database of Systematic Reviews 20XX, Issue #. Art. No.: CD00XXXX. DOI: 10.1002/14651858.CD00XXXX (insert persistent link to the article by using the URL: http://dx.doi.org/10.1002/14651858.CD00XXXX) (This statement should refer to the most recent issue of the Cochrane Database of Systematic Reviews in which the Review published.)-
dc.titleInterim analysis of the natural history of chronic hepatitis C genotype 1 and 6-
dc.typeConference_Paper-
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0270-9139&volume=48&issue=Suppl 1&spage=1102A&epage=&date=2008&atitle=Interim+analysis+of+the+natural+history+of+chronic+hepatitis+C+genotype+1+and+6en_HK
dc.identifier.emailSeto, WKW: wkseto@hku.hk-
dc.identifier.emailLai, CL: hrmelcl@hku.hk-
dc.identifier.emailFung, JYY: jfung@HKUCC.hku.hk-
dc.identifier.emailYoung, JLP: jlpyoung@hku.hk-
dc.identifier.emailYuen, JCH: jchyuen@HKUCC.hku.hk-
dc.identifier.emailWong, DKH: danywong@hku.hk-
dc.identifier.emailYuen, RMF: mfyuen@hkucc.hku.hk-
dc.identifier.authoritySeto, WKW=rp01659-
dc.identifier.authorityLai, CL=rp00314-
dc.identifier.authorityFung, JYY=rp00518-
dc.identifier.authorityWong, DKH=rp00492-
dc.identifier.authorityYuen, RMF=rp00479-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hep.22647-
dc.identifier.hkuros161373-
dc.identifier.volume48-
dc.identifier.issueSuppl 1-
dc.identifier.spage1102A-
dc.identifier.epage1102A-
dc.publisher.placeUnited States-

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