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Conference Paper: Gd-DTPA enhanced MRI revealed leakage at aqueous-vitreous interface upon ocular hypertension

TitleGd-DTPA enhanced MRI revealed leakage at aqueous-vitreous interface upon ocular hypertension
Authors
Issue Date2009
PublisherInternational Society for Magnetic Resonance in Medicine.
Citation
The 17th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM), Honolulu, HI., 18-24 April 2009. In Proceedings of ISMRM 17th Scientific Meeting & Exhibition, 2009, p. 749 How to Cite?
AbstractThis study aims to employ in vivo contrast-enhanced MRI to evaluate the ocular transport upon an induction of ocular hypertension in the right eye in a rat model of chronic glaucoma. Following systemic administration of Gd-DTPA solution, our results showed a progressive T1-weighted signal increase in the anterior vitreous body of the glaucomatous eye but not the control eye, suggestive of the leakage of Gd-DTPA at the aqueous-vitreous interface. These findings may explain the sources of changing biochemical compositions in the glaucomatous chamber components, which may implicate the cascades of neurodegenerative processes in the retina and the optic nerve. Our findings of the early Gd-DTPA signal enhancements in the anterior vitreous body than the preretinal vitreous provided a noninvasive marker for the disease. More importantly, this approach could have direct clinical applications and can be readily translated to humans.
DescriptionSession 75: Perfusion & Diffusion: Animal Models - Oral presentation
Persistent Identifierhttp://hdl.handle.net/10722/62130
ISBN

 

DC FieldValueLanguage
dc.contributor.authorChan, KCWen_HK
dc.contributor.authorFu, Qen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-07-13T03:54:29Z-
dc.date.available2010-07-13T03:54:29Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 17th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM), Honolulu, HI., 18-24 April 2009. In Proceedings of ISMRM 17th Scientific Meeting & Exhibition, 2009, p. 749en_HK
dc.identifier.isbn9781615673384-
dc.identifier.urihttp://hdl.handle.net/10722/62130-
dc.descriptionSession 75: Perfusion & Diffusion: Animal Models - Oral presentation-
dc.description.abstractThis study aims to employ in vivo contrast-enhanced MRI to evaluate the ocular transport upon an induction of ocular hypertension in the right eye in a rat model of chronic glaucoma. Following systemic administration of Gd-DTPA solution, our results showed a progressive T1-weighted signal increase in the anterior vitreous body of the glaucomatous eye but not the control eye, suggestive of the leakage of Gd-DTPA at the aqueous-vitreous interface. These findings may explain the sources of changing biochemical compositions in the glaucomatous chamber components, which may implicate the cascades of neurodegenerative processes in the retina and the optic nerve. Our findings of the early Gd-DTPA signal enhancements in the anterior vitreous body than the preretinal vitreous provided a noninvasive marker for the disease. More importantly, this approach could have direct clinical applications and can be readily translated to humans.-
dc.languageengen_HK
dc.publisherInternational Society for Magnetic Resonance in Medicine.-
dc.relation.ispartofProceedings of ISMRM 17th Scientific Meeting & Exhibition-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleGd-DTPA enhanced MRI revealed leakage at aqueous-vitreous interface upon ocular hypertensionen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, KCW: kevin_ccw@hkusa.hku.hken_HK
dc.identifier.emailFu, Q: qingling@hku.hk-
dc.identifier.emailSo, KF: hrmaskf@hku.hk-
dc.identifier.emailWu, EX: ewu@eee.hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros162028en_HK
dc.identifier.spage749-
dc.identifier.epage749-
dc.publisher.placeUnited States-
dc.description.otherThe 17th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM), Honolulu, HI., 18-24 April 2009. In Proceedings of ISMRM 17th Scientific Meeting & Exhibition, 2009, p. 749-

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