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Conference Paper: Characterization of white matter reorganization in neonatal hypoxic-ischemic cerebral injury using diffusion tensor imaging

TitleCharacterization of white matter reorganization in neonatal hypoxic-ischemic cerebral injury using diffusion tensor imaging
Authors
Issue Date2009
PublisherInternational Society of Magnetic Resonance in Medicine.
Citation
The 17th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM), Honolulu, HI., 18-24 April 2009. In Proceedings of ISMRM 17th Scientific Meeting & Exhibition, 2009, p. 3270 How to Cite?
AbstractThis study employs in vivo diffusion tensor imaging (DTI) to understand the late changes in white matter (WM) injury and reorganization in the rat brain upon neonatal hypoxic-ischemic cerebral injury. In particular, detailed inspection of the color-encoded fractional anisotropy (FA) map of the principal eigenvector was performed to compare the orientations of the high FA fibers at the perilesional areas with the WM microstructures in the contralateral hemisphere. In addition to the differences in DTI parameters in the microstructures between both hemispheres, results showed that the perilesional areas had similar fiber orientations as the contralateral external capsule in the anterior section of the brain, and as the internal capsule and the fimbria of hippocampus in the posterior section. We demonstrated that DTI can detect the microstructure and orientations of WM fiber changes at the perilesional areas in vivo, and can be used for non-invasive evaluation of HI brain injuries and reorganization.
DescriptionAnimal Models of Ischemia: Characterization - Poster presentation
Persistent Identifierhttp://hdl.handle.net/10722/62106
ISBN

 

DC FieldValueLanguage
dc.contributor.authorChan, KCWen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorLau, HFen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-07-13T03:54:01Z-
dc.date.available2010-07-13T03:54:01Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 17th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM), Honolulu, HI., 18-24 April 2009. In Proceedings of ISMRM 17th Scientific Meeting & Exhibition, 2009, p. 3270en_HK
dc.identifier.isbn9781615673384-
dc.identifier.urihttp://hdl.handle.net/10722/62106-
dc.descriptionAnimal Models of Ischemia: Characterization - Poster presentation-
dc.description.abstractThis study employs in vivo diffusion tensor imaging (DTI) to understand the late changes in white matter (WM) injury and reorganization in the rat brain upon neonatal hypoxic-ischemic cerebral injury. In particular, detailed inspection of the color-encoded fractional anisotropy (FA) map of the principal eigenvector was performed to compare the orientations of the high FA fibers at the perilesional areas with the WM microstructures in the contralateral hemisphere. In addition to the differences in DTI parameters in the microstructures between both hemispheres, results showed that the perilesional areas had similar fiber orientations as the contralateral external capsule in the anterior section of the brain, and as the internal capsule and the fimbria of hippocampus in the posterior section. We demonstrated that DTI can detect the microstructure and orientations of WM fiber changes at the perilesional areas in vivo, and can be used for non-invasive evaluation of HI brain injuries and reorganization.-
dc.languageengen_HK
dc.publisherInternational Society of Magnetic Resonance in Medicine.-
dc.relation.ispartofProceedings of ISMRM 17th Scientific Meeting & Exhibition-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleCharacterization of white matter reorganization in neonatal hypoxic-ischemic cerebral injury using diffusion tensor imagingen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, KCW: kevin_ccw@hkusa.hku.hken_HK
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hk-
dc.identifier.emailLau, HF: lauhofai@gmail.com-
dc.identifier.emailWu, EX: ewu@eee.hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros162092en_HK
dc.identifier.spage3270-
dc.identifier.epage3270-
dc.publisher.placeUnited States-
dc.description.otherThe 17th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM), Honolulu, HI., 18-24 April 2009. In Proceedings of ISMRM 17th Scientific Meeting & Exhibition, 2009, p. 3270-

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