Conference Paper: Late manganese-enhanced MRI of rat cortical and subcortical structures

TitleLate manganese-enhanced MRI of rat cortical and subcortical structures
Authors
Issue Date2009
PublisherInternational Society of Magnetic Resonance in Medicine.
Citation
The 17th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM), Honolulu, HI., 18-24 April 2009. In Proceedings of ISMRM 17th Scientific Meeting & Exhibition, 2009, p. 1288 How to Cite?
AbstractThis study employs in vivo manganese-enhanced MRI (MEMRI) before, and at 1, 5 and 12 days after systemic Mn administration to investigate the late enhancement of rat brain tissues before global clearance of Mn from the brain. While most brain structures were found maximally enhanced in T1WI at 1 day after Mn injection, a higher signal increase was observed at Day 5 in the central amygdaloid nucleus, globus pallidus, ventral pallidum, caudate putamen and thalamus compared to other time points. Our results suggested the deposition of Mn in areas of high astrocyte densities at 1 day after systemic Mn administration, with continuous redistribution of Mn through axonal transport in the late phase before its global clearance from the brain at Day 12.
DescriptionManganese Enhanced MRI - Poster presentation
Persistent Identifierhttp://hdl.handle.net/10722/62099
ISBN

 

DC FieldValueLanguage
dc.contributor.authorChan, KCWen_HK
dc.contributor.authorZhou, IYen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-07-13T03:53:52Z-
dc.date.available2010-07-13T03:53:52Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 17th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM), Honolulu, HI., 18-24 April 2009. In Proceedings of ISMRM 17th Scientific Meeting & Exhibition, 2009, p. 1288en_HK
dc.identifier.isbn9781615673384-
dc.identifier.urihttp://hdl.handle.net/10722/62099-
dc.descriptionManganese Enhanced MRI - Poster presentation-
dc.description.abstractThis study employs in vivo manganese-enhanced MRI (MEMRI) before, and at 1, 5 and 12 days after systemic Mn administration to investigate the late enhancement of rat brain tissues before global clearance of Mn from the brain. While most brain structures were found maximally enhanced in T1WI at 1 day after Mn injection, a higher signal increase was observed at Day 5 in the central amygdaloid nucleus, globus pallidus, ventral pallidum, caudate putamen and thalamus compared to other time points. Our results suggested the deposition of Mn in areas of high astrocyte densities at 1 day after systemic Mn administration, with continuous redistribution of Mn through axonal transport in the late phase before its global clearance from the brain at Day 12.-
dc.languageengen_HK
dc.publisherInternational Society of Magnetic Resonance in Medicine.-
dc.relation.ispartofProceedings of ISMRM 17th Scientific Meeting & Exhibition-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleLate manganese-enhanced MRI of rat cortical and subcortical structuresen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, KCW: kevin_ccw@hkusa.hku.hken_HK
dc.identifier.emailZhou, IY: iriszhou@eee.hku.hk-
dc.identifier.emailWu, EX: ewu@eee.hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros162095en_HK
dc.identifier.spage1288-
dc.identifier.epage1288-
dc.publisher.placeUnited States-
dc.description.otherThe 17th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM), Honolulu, HI., 18-24 April 2009. In Proceedings of ISMRM 17th Scientific Meeting & Exhibition, 2009, p. 1288-

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