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Conference Paper: MRI detection of progenitor cell migrations during postnatal rat brain development by in situ MPIO labeling
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TitleMRI detection of progenitor cell migrations during postnatal rat brain development by in situ MPIO labeling
 
AuthorsYang, J
Liu, J
Niu, G
Wang, R
Liu, Y
Yu, B
Wu, EX
 
Issue Date2009
 
PublisherInternational Society of Magnetic Resonance in Medicine.
 
CitationThe 17th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM), Honolulu, HI., 18-24 April 2009. In Proceedings of ISMRM 17th Scientific Meeting & Exhibition, 2009, p. 3168 [How to Cite?]
 
AbstractIn this study, micron-sized iron oxide particles (MPIOs) were injected into the left anterior lateral ventricle of 10-day-old normal rats. T2- and T2*-weighted images were acquired using a 7T scanner at day 1, 3, 7 and 14 after the MPIO injection. Histological analyses were then performed to identify MPIOs in different migrating cells, namely, neural progenitor and astrocytes-like progenitor cells. The migrating pathways of the MPIO-labeled endogenous progenitors exhibited a predominantly bidirectional, rostrocaudal pattern in tangential orientation. Such in situ MPIO labeling approach opens the possibility of using MRI to study the mechanism of cell migration in developing brain.
 
DescriptionMolecules & Cells: Novel Applications - Poster presentation
 
ISBN9781615673384
 
DC FieldValue
dc.contributor.authorYang, J
 
dc.contributor.authorLiu, J
 
dc.contributor.authorNiu, G
 
dc.contributor.authorWang, R
 
dc.contributor.authorLiu, Y
 
dc.contributor.authorYu, B
 
dc.contributor.authorWu, EX
 
dc.date.accessioned2010-07-13T03:52:35Z
 
dc.date.available2010-07-13T03:52:35Z
 
dc.date.issued2009
 
dc.description.abstractIn this study, micron-sized iron oxide particles (MPIOs) were injected into the left anterior lateral ventricle of 10-day-old normal rats. T2- and T2*-weighted images were acquired using a 7T scanner at day 1, 3, 7 and 14 after the MPIO injection. Histological analyses were then performed to identify MPIOs in different migrating cells, namely, neural progenitor and astrocytes-like progenitor cells. The migrating pathways of the MPIO-labeled endogenous progenitors exhibited a predominantly bidirectional, rostrocaudal pattern in tangential orientation. Such in situ MPIO labeling approach opens the possibility of using MRI to study the mechanism of cell migration in developing brain.
 
dc.description.naturepublished_or_final_version
 
dc.descriptionMolecules & Cells: Novel Applications - Poster presentation
 
dc.description.otherThe 17th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM), Honolulu, HI., 18-24 April 2009. In Proceedings of ISMRM 17th Scientific Meeting & Exhibition, 2009, p. 3168
 
dc.identifier.citationThe 17th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM), Honolulu, HI., 18-24 April 2009. In Proceedings of ISMRM 17th Scientific Meeting & Exhibition, 2009, p. 3168 [How to Cite?]
 
dc.identifier.epage3168
 
dc.identifier.hkuros162040
 
dc.identifier.isbn9781615673384
 
dc.identifier.spage3168
 
dc.identifier.urihttp://hdl.handle.net/10722/62036
 
dc.languageeng
 
dc.publisherInternational Society of Magnetic Resonance in Medicine.
 
dc.publisher.placeUnited States
 
dc.relation.ispartofProceedings of ISMRM 17th Scientific Meeting & Exhibition
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.titleMRI detection of progenitor cell migrations during postnatal rat brain development by in situ MPIO labeling
 
dc.typeConference_Paper
 
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