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Conference Paper: Dynamic contrast-enhanced MRI of ocular biotransport in normal and hypertensive eyes

TitleDynamic contrast-enhanced MRI of ocular biotransport in normal and hypertensive eyes
Authors
Issue Date2008
PublisherIEEE. The Journal's web site is located at http://www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269
Citation
Proceedings Of The 30Th Annual International Conference Of The Ieee Engineering In Medicine And Biology Society, Embs'08 - Personalized Healthcare Through Technology, 2008, p. 835-838 How to Cite?
AbstractThis study aims to employ in vivo dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to evaluate the ocular transport following an induction of ocular hypertension in a rat model of chronic glaucoma. Upon systemic administration of Gd-DTPA solution, T1-weighted signal increase was observed in the vitreous body of the glaucomatous eye but not the control eye. This increase occurred earlier in the anterior vitreous body than the preretinal vitreous. Further, there was an earlier Gd-DTPA transport into the anterior chamber in the majority of glaucomatous eyes. Our DCE-MRI findings revealed the leakage of Gd-DTPA at the aqueous-vitreous interface, which was likely resulted from increased permeability of blood-aqueous or aqueous-vitreous barrier. These may explain the sources of changing biochemical compositions in the chamber components, which may implicate the neurodegenerative processes in the glaucomatous visual components. © 2008 IEEE.
DescriptionProceedings of the IEEE Engineering in Medicine and Biology Society Conference, 2008, p. 835-838
Persistent Identifierhttp://hdl.handle.net/10722/62016
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorChan, KCen_HK
dc.contributor.authorFu, QLen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-07-13T03:52:10Z-
dc.date.available2010-07-13T03:52:10Z-
dc.date.issued2008en_HK
dc.identifier.citationProceedings Of The 30Th Annual International Conference Of The Ieee Engineering In Medicine And Biology Society, Embs'08 - Personalized Healthcare Through Technology, 2008, p. 835-838en_HK
dc.identifier.issn1557-170Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/62016-
dc.descriptionProceedings of the IEEE Engineering in Medicine and Biology Society Conference, 2008, p. 835-838en_HK
dc.description.abstractThis study aims to employ in vivo dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to evaluate the ocular transport following an induction of ocular hypertension in a rat model of chronic glaucoma. Upon systemic administration of Gd-DTPA solution, T1-weighted signal increase was observed in the vitreous body of the glaucomatous eye but not the control eye. This increase occurred earlier in the anterior vitreous body than the preretinal vitreous. Further, there was an earlier Gd-DTPA transport into the anterior chamber in the majority of glaucomatous eyes. Our DCE-MRI findings revealed the leakage of Gd-DTPA at the aqueous-vitreous interface, which was likely resulted from increased permeability of blood-aqueous or aqueous-vitreous barrier. These may explain the sources of changing biochemical compositions in the chamber components, which may implicate the neurodegenerative processes in the glaucomatous visual components. © 2008 IEEE.en_HK
dc.languageengen_HK
dc.publisherIEEE. The Journal's web site is located at http://www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269-
dc.relation.ispartofProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsIEEE Engineering in Medicine and Biology Society. Conference Proceedings. Copyright © IEEE.-
dc.rights©2008 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.-
dc.subject.meshAnimals-
dc.subject.meshGadolinium DTPA - diagnostic use - pharmacokinetics-
dc.subject.meshGlaucoma - metabolism - pathology-
dc.subject.meshMagnetic Resonance Imaging - methods-
dc.subject.meshOcular Hypertension - metabolism - pathology-
dc.titleDynamic contrast-enhanced MRI of ocular biotransport in normal and hypertensive eyesen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1557-170X&volume=&spage=835&epage=838&date=2008&atitle=Dynamic+contrast-enhanced+MRI+of+ocular+biotransport+in+normal+and+hypertensive+eyes-
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1109/IEMBS.2008.4649283-
dc.identifier.pmid19162786en_HK
dc.identifier.scopuseid_2-s2.0-61849086125en_HK
dc.identifier.hkuros162003en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-61849086125&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.spage835en_HK
dc.identifier.epage838en_HK
dc.identifier.scopusauthoridChan, KC=34968940300en_HK
dc.identifier.scopusauthoridFu, QL=23388762000en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

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