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Conference Paper: Preliminary in vitro study of ultrasound sonoporation cell labeling with superparamagnetic iron oxide particles for MRI cell tracking

TitlePreliminary in vitro study of ultrasound sonoporation cell labeling with superparamagnetic iron oxide particles for MRI cell tracking
Authors
Issue Date2008
PublisherIEEE. The Journal's web site is located at http://www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269
Citation
Proceedings Of The 30Th Annual International Conference Of The Ieee Engineering In Medicine And Biology Society, Embs'08 - Personalized Healthcare Through Technology, 2008, p. 367-370 How to Cite?
AbstractVibration caused by ultrasonic waves can change the structure of cell membrane and enhance its permeation. In the last decade, a new ultrasound-aided method, sonoporation, has been proposed and utilized to transmit target molecules (such as drugs and DNA) into cells for therapy. The objective of this study was to investigate the method of loading nanometer-sized superparamagnetic iron oxide particles into Sarcoma 180 cells by sonoporation without chemical agents. The SPIO nanoparticles were prepared in our laboratory by means of classical coprecipitation and the formation of Fe3O4 crystal in SPIO nanoparticles was confirmed by x-ray diffraction analysis with its other characteristics assessed by magnetic hysteresis loops and size distribution. Cell labeling with SPIOs using sonoporation was successfully demonstrated in vitro for sarcoma180 cell suspensions from ICR mice. The labeling efficiency and viability were evaluated by Prussian blue staining. Such sonoporation technique can be employed for rapid labeling of various cells for MRI visualization of their spatiotemporal activities in vivo upon transplantation. © 2008 IEEE.
DescriptionProceedings of the IEEE Engineering in Medicine and Biology Society Conference, 2008, p. 367-370
Persistent Identifierhttp://hdl.handle.net/10722/62002
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorMo, Ren_HK
dc.contributor.authorLin, Sen_HK
dc.contributor.authorWang, Gen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-07-13T03:51:53Z-
dc.date.available2010-07-13T03:51:53Z-
dc.date.issued2008en_HK
dc.identifier.citationProceedings Of The 30Th Annual International Conference Of The Ieee Engineering In Medicine And Biology Society, Embs'08 - Personalized Healthcare Through Technology, 2008, p. 367-370en_HK
dc.identifier.issn1557-170Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/62002-
dc.descriptionProceedings of the IEEE Engineering in Medicine and Biology Society Conference, 2008, p. 367-370-
dc.description.abstractVibration caused by ultrasonic waves can change the structure of cell membrane and enhance its permeation. In the last decade, a new ultrasound-aided method, sonoporation, has been proposed and utilized to transmit target molecules (such as drugs and DNA) into cells for therapy. The objective of this study was to investigate the method of loading nanometer-sized superparamagnetic iron oxide particles into Sarcoma 180 cells by sonoporation without chemical agents. The SPIO nanoparticles were prepared in our laboratory by means of classical coprecipitation and the formation of Fe3O4 crystal in SPIO nanoparticles was confirmed by x-ray diffraction analysis with its other characteristics assessed by magnetic hysteresis loops and size distribution. Cell labeling with SPIOs using sonoporation was successfully demonstrated in vitro for sarcoma180 cell suspensions from ICR mice. The labeling efficiency and viability were evaluated by Prussian blue staining. Such sonoporation technique can be employed for rapid labeling of various cells for MRI visualization of their spatiotemporal activities in vivo upon transplantation. © 2008 IEEE.en_HK
dc.languageengen_HK
dc.publisherIEEE. The Journal's web site is located at http://www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269-
dc.relation.ispartofProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"en_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsIEEE Engineering in Medicine and Biology Society. Conference Proceedings. Copyright © IEEE.-
dc.rights©2008 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.-
dc.subject.meshElectroporation - methods-
dc.subject.meshFerric Compounds - diagnostic use - pharmacokinetics-
dc.subject.meshMagnetic Resonance Imaging - methods-
dc.subject.meshSarcoma - metabolism - pathology-
dc.subject.meshSonication-
dc.titlePreliminary in vitro study of ultrasound sonoporation cell labeling with superparamagnetic iron oxide particles for MRI cell trackingen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1557-170X&volume=&spage=367&epage=370&date=2008&atitle=Preliminary+in+vitro+study+of+ultrasound+sonoporation+cell+labeling+with+superparamagnetic+iron+oxide+particles+for+MRI+cell+tracking-
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1109/IEMBS.2008.4649166-
dc.identifier.pmid19162669-
dc.identifier.scopuseid_2-s2.0-61849138238en_HK
dc.identifier.hkuros161993en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-61849138238&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.spage367en_HK
dc.identifier.epage370en_HK
dc.identifier.scopusauthoridMo, R=26321792100en_HK
dc.identifier.scopusauthoridLin, S=6701705623en_HK
dc.identifier.scopusauthoridWang, G=7407616522en_HK
dc.identifier.scopusauthoridWang, Y=18234405600en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

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