An LMI approach for robust stability of genetic networks

Abstract

This paper addresses the problem of establishing robust stability of uncertain genetic networks with SUM regulatory functions. For these networks we derive a sufficient condition for robust stability by introducing a bounding set of the uncertain nonlinearity, and we show that this condition can be formulated as a linear matrix inequality (LMI) optimization obtained via the square matricial representation (SMR) of polynomials by adopting polynomial Lyapunov functions and polynomial descriptions of the bounding set. Then, we propose a method for computing a family of bounding sets by means of convex optimizations. It is worthwhile to remark that these results are derived in spite of the fact that the variable equilibrium point cannot be computed being the solution of a system of parameter-dependent nonlinear equations, and is hence unknown.