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Conference Paper: Mild hypoxic-ischemic injury in the neonatal rat brain: longitudinal evaluation of the white matter using diffusion tensor MR imaging

TitleMild hypoxic-ischemic injury in the neonatal rat brain: longitudinal evaluation of the white matter using diffusion tensor MR imaging
Authors
Issue Date2009
PublisherInternational Society of Magnetic Resonance in Medicine.
Citation
The 17th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM), Honolulu, HI., 18-24 April 2009. In Proceedings of ISMRM 17th Scientific Meeting & Exhibition, 2009, p. 743 How to Cite?
AbstractWe evaluated longitudinally mild hypoxic-ischemic (HI) induced white matter (WM) damage in a neonatal rat model using DTI and correlated the DTI indices with histological evaluations. Results showed significantly decreased FA and increased ¦Ë¡Í in the injured WM reflected dysmyelination. The longitudinal changes of increasing FA, decreasing ¦Ë¡Í, and no change in ¦Ë// in both injured and control WM suggests continued myelination. Furthermore, differences in FA and ¦Ë¡Í between injured and control WM decreased longitudinally. Our results demonstrated that mild HI induced WM damage continues to mature with partial recovery post-HI, and this could be reflected by DTI in vivo.
DescriptionSession 75: Perfusion & Diffusion: Animal Models - Oral presentation
Persistent Identifierhttp://hdl.handle.net/10722/61968
ISBN

 

DC FieldValueLanguage
dc.contributor.authorWang, Sen_HK
dc.contributor.authorWu, EXen_HK
dc.contributor.authorCai, Ken_HK
dc.contributor.authorLau, HFen_HK
dc.contributor.authorKhong, PLen_HK
dc.date.accessioned2010-07-13T03:51:12Z-
dc.date.available2010-07-13T03:51:12Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 17th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM), Honolulu, HI., 18-24 April 2009. In Proceedings of ISMRM 17th Scientific Meeting & Exhibition, 2009, p. 743en_HK
dc.identifier.isbn9781615673384-
dc.identifier.urihttp://hdl.handle.net/10722/61968-
dc.descriptionSession 75: Perfusion & Diffusion: Animal Models - Oral presentation-
dc.description.abstractWe evaluated longitudinally mild hypoxic-ischemic (HI) induced white matter (WM) damage in a neonatal rat model using DTI and correlated the DTI indices with histological evaluations. Results showed significantly decreased FA and increased ¦Ë¡Í in the injured WM reflected dysmyelination. The longitudinal changes of increasing FA, decreasing ¦Ë¡Í, and no change in ¦Ë// in both injured and control WM suggests continued myelination. Furthermore, differences in FA and ¦Ë¡Í between injured and control WM decreased longitudinally. Our results demonstrated that mild HI induced WM damage continues to mature with partial recovery post-HI, and this could be reflected by DTI in vivo.-
dc.languageengen_HK
dc.publisherInternational Society of Magnetic Resonance in Medicine.-
dc.relation.ispartofProceedings of ISMRM 17th Scientific Meeting & Exhibition-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleMild hypoxic-ischemic injury in the neonatal rat brain: longitudinal evaluation of the white matter using diffusion tensor MR imagingen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWu, EX: ewu@eee.hku.hken_HK
dc.identifier.emailCai, K: iinvivo@gmail.com-
dc.identifier.emailLau, HF: lauhofai@gmail.com-
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros161450en_HK
dc.identifier.hkuros162038-
dc.identifier.spage743-
dc.identifier.epage743-
dc.publisher.placeUnited States-
dc.description.otherThe 17th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM), Honolulu, HI., 18-24 April 2009. In Proceedings of ISMRM 17th Scientific Meeting & Exhibition, 2009, p. 743-

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