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Conference Paper: Crystal clear surgery using self-assembling molecules that act as a bio barrier in the brain and spinal cord

TitleCrystal clear surgery using self-assembling molecules that act as a bio barrier in the brain and spinal cord
Authors
Issue Date2008
PublisherSociety for Neuroscience
Citation
Neuroscience 2008, Washington, DC, 15-19 November 2008, Program#/Poster#: 888.6/VV8 How to Cite?
AbstractThe surgical field is often obscured with blood and debris during an operation. In addition, clearing debris from the surgical field usually requires irrigating the site with saline. Saline is only a temporary solution and needs to be continuously applied to maintain a clear surgical field. This poses several issues: 1) Any contamination in existence will easily spread; 2) a small opening will require alternating between irrigation and operating and 3) during neural operations movement of liquid can result in a massive infection leading to post-operative complications. Here we show that a self-assembling peptide (SAP) nanofiber scaffold can provide a transparent cover for the surgical field. This optically clear liquid allows operation through the resultant gel while at the same time creating a bio barrier. Using SAP for biological confinement can reduce post operative complications in open surgical procedures. Surgery was performed using this material on 218 adult Syrian hamsters and rats in the brain, spinal cord, arteries and veins. Several examples of neurosurgical procedures using the material will be presented, showing how in vivo biological confinement may change the face of neural surgery and allow for reconstructive neurosurgery.
Persistent Identifierhttp://hdl.handle.net/10722/61444

 

DC FieldValueLanguage
dc.contributor.authorEllis-Behnke, RGen_HK
dc.contributor.authorTay, DKCen_HK
dc.contributor.authorLiang, Yen_HK
dc.contributor.authorSchneider, GEen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2010-07-13T03:39:48Z-
dc.date.available2010-07-13T03:39:48Z-
dc.date.issued2008en_HK
dc.identifier.citationNeuroscience 2008, Washington, DC, 15-19 November 2008, Program#/Poster#: 888.6/VV8-
dc.identifier.urihttp://hdl.handle.net/10722/61444-
dc.description.abstractThe surgical field is often obscured with blood and debris during an operation. In addition, clearing debris from the surgical field usually requires irrigating the site with saline. Saline is only a temporary solution and needs to be continuously applied to maintain a clear surgical field. This poses several issues: 1) Any contamination in existence will easily spread; 2) a small opening will require alternating between irrigation and operating and 3) during neural operations movement of liquid can result in a massive infection leading to post-operative complications. Here we show that a self-assembling peptide (SAP) nanofiber scaffold can provide a transparent cover for the surgical field. This optically clear liquid allows operation through the resultant gel while at the same time creating a bio barrier. Using SAP for biological confinement can reduce post operative complications in open surgical procedures. Surgery was performed using this material on 218 adult Syrian hamsters and rats in the brain, spinal cord, arteries and veins. Several examples of neurosurgical procedures using the material will be presented, showing how in vivo biological confinement may change the face of neural surgery and allow for reconstructive neurosurgery.-
dc.languageengen_HK
dc.publisherSociety for Neuroscience-
dc.relation.ispartofSociety for Neuroscience Annual Meeting-
dc.titleCrystal clear surgery using self-assembling molecules that act as a bio barrier in the brain and spinal corden_HK
dc.typeConference_Paperen_HK
dc.identifier.emailEllis-Behnke, RG: rutledg@mit.eduen_HK
dc.identifier.emailLiang, Y: yxliang99@yahoo.com.cnen_HK
dc.identifier.emailTay, DKC: dkctay@hkucc.hku.hken_HK
dc.identifier.emailWu, W: wtwu@hkucc.hku.hken_HK
dc.identifier.emailSo, KF: hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityEllis-Behnke, RG=rp00252en_HK
dc.identifier.authorityLiang, Y=rp00510en_HK
dc.identifier.authorityTay, DKC=rp00336en_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.hkuros147152en_HK

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