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Conference Paper: Over-expression of endothelin-1 in astrocytes lead to chronic cognitive deficit and brain edema after transient middle cerebral artery occlusion

TitleOver-expression of endothelin-1 in astrocytes lead to chronic cognitive deficit and brain edema after transient middle cerebral artery occlusion
Authors
Issue Date2008
PublisherSociety for Neuroscience.
Citation
The 38th Annual Meeting of the Society for Neuroscience (Neuroscience 2008), Washington, DC., 15-19 November 2008, Program#/Poster#: 748.11/Y15 How to Cite?
AbstractPreviously, we demonstrated that transgenic mice with the overexpression of endothelin-1 (ET-1) in astrocyte (GET-1) displayed more severe sensorimotor deficits, larger infarct volume and edema after 2 hours of middle cerebral artery occlusion (MCAO) and 22 hours of reperfusion. However, it is not clear whether astrocytic ET-1 has chronic functional deficit after transient MCAO. Here, GET-1 and non-transgenic mice were challenged with 30 minutes of ischemia followed by 1, 3, 7 days and 1, 3 or 5 months of reperfusion. Cognitive deficit was determined by testing their spatial reference memory as well as evaluating their brain lesion and edema by T2-weighted MRI (T2WI). T2WI results indicated that severe brain infarct and edema occurred 3 days after injury in GET-1 mice in the cortex and hippocampus. In addition, glial fibillary acidic protein (GFAP) staining revealed that the number of reactivated astrocytes was increased dramatically in the similar areas with T2WI positive signal. Progressive tissue loss was subsequently observed in the same areas when assessed 3 months after injury. In line with the imaging and histological data, GET-1 mice exhibited severe spatial reference memory impairment when assessed 7 days and 3 months after injury. Taken together, astrocytic ET-1 contributed to cognitive function deficit associated with brain edema and infarct induced by short duration of ischemia.
Persistent Identifierhttp://hdl.handle.net/10722/61443

 

DC FieldValueLanguage
dc.contributor.authorHung, VKLen_HK
dc.contributor.authorLai, AKWen_HK
dc.contributor.authorChan, KCen_HK
dc.contributor.authorWu, EXen_HK
dc.contributor.authorLo, ACYen_HK
dc.contributor.authorChung, SSMen_HK
dc.contributor.authorChung, SK-
dc.date.accessioned2010-07-13T03:39:46Z-
dc.date.available2010-07-13T03:39:46Z-
dc.date.issued2008en_HK
dc.identifier.citationThe 38th Annual Meeting of the Society for Neuroscience (Neuroscience 2008), Washington, DC., 15-19 November 2008, Program#/Poster#: 748.11/Y15en_HK
dc.identifier.urihttp://hdl.handle.net/10722/61443-
dc.description.abstractPreviously, we demonstrated that transgenic mice with the overexpression of endothelin-1 (ET-1) in astrocyte (GET-1) displayed more severe sensorimotor deficits, larger infarct volume and edema after 2 hours of middle cerebral artery occlusion (MCAO) and 22 hours of reperfusion. However, it is not clear whether astrocytic ET-1 has chronic functional deficit after transient MCAO. Here, GET-1 and non-transgenic mice were challenged with 30 minutes of ischemia followed by 1, 3, 7 days and 1, 3 or 5 months of reperfusion. Cognitive deficit was determined by testing their spatial reference memory as well as evaluating their brain lesion and edema by T2-weighted MRI (T2WI). T2WI results indicated that severe brain infarct and edema occurred 3 days after injury in GET-1 mice in the cortex and hippocampus. In addition, glial fibillary acidic protein (GFAP) staining revealed that the number of reactivated astrocytes was increased dramatically in the similar areas with T2WI positive signal. Progressive tissue loss was subsequently observed in the same areas when assessed 3 months after injury. In line with the imaging and histological data, GET-1 mice exhibited severe spatial reference memory impairment when assessed 7 days and 3 months after injury. Taken together, astrocytic ET-1 contributed to cognitive function deficit associated with brain edema and infarct induced by short duration of ischemia.-
dc.languageengen_HK
dc.publisherSociety for Neuroscience.-
dc.relation.ispartofSociety for Neuroscience Annual Meeting-
dc.rightsAnnual Meeting of the Society for Neuroscience. Copyright © Society for Neuroscience.-
dc.titleOver-expression of endothelin-1 in astrocytes lead to chronic cognitive deficit and brain edema after transient middle cerebral artery occlusionen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailWu, EX: ewu@eee.hku.hken_HK
dc.identifier.emailLo, ACY: amylo@hkucc.hku.hken_HK
dc.identifier.emailChung, SSM: smchung@hkucc.hku.hken_HK
dc.identifier.emailChung, SK: skchung@hkucc.hku.hken_HK
dc.identifier.hkuros161965en_HK
dc.description.otherThe 38th Annual Meeting of the Society for Neuroscience (Neuroscience 2008), Washington, DC., 15-19 November 2008.-

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