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Conference Paper: Endoplasmic reticulum stress in aged P301L Tau transgenic mice

TitleEndoplasmic reticulum stress in aged P301L Tau transgenic mice
Authors
Issue Date2009
PublisherElsevier Inc. The Journal's web site is located at http://www.alzheimersanddementia.org/
Citation
Alzheimer's Association International Conference on Alzheimer's Disease, 2009. In Alzheimer's & Dementia, 2009, v. 5 n. 4 Suppl, p. P397–P398 How to Cite?
AbstractBackground: Accumulating evidence indicates that abnormalities in tau protein play a critical role in the pathogenesis of Alzheimer's disease (AD). Endoplasmic reticulum (ER) stress has been implicated in pathological processes resulting in neuronal death in AD. However, the potential connection of tau abnormalities and ER stress was not explored. Methods: Immunofluorescence staining of phosphorylated tau (pT231) and ER stress markers PERK and CHOP was performed to determine any colocalization of phosphorylated tau and increased ER-stress markers in aged (22 months old) transgenic mice expressing the P301L mutated form of human tau. Furthermore, Western-blot analysis was used to detect the levels of BiP, one of ER stress markers, and phosphorylation of eIF2α. Results: Immunfluorescence analysis revealed that activation of PERK (increased phosphorylation of PERK) and increased expression of CHOP were observed in hippocampal neurons containing accumulation of phosphorylated tau in the aged transgenic mice. Western-blot analysis revealed that the levels of BiP and phosphorylation of eIF2α were significantly increased in the hippocampus of aged transgenic mice. Conclusions: Our data indicate that in addition to β-amyloid peptide, pathological tau can also induce ER stress, which can be involved in promoting neuronal loss (apoptosis) observed in this transgenic mouse model and AD cases.
Persistent Identifierhttp://hdl.handle.net/10722/61401
ISSN
2015 Impact Factor: 11.619
2015 SCImago Journal Rankings: 4.289

 

DC FieldValueLanguage
dc.contributor.authorYang, Xen_HK
dc.contributor.authorHo, YSen_HK
dc.contributor.authorBaum, Len_HK
dc.contributor.authorLi, Gen_HK
dc.contributor.authorWang, Jen_HK
dc.contributor.authorChang, RCCen_HK
dc.date.accessioned2010-07-13T03:38:56Z-
dc.date.available2010-07-13T03:38:56Z-
dc.date.issued2009en_HK
dc.identifier.citationAlzheimer's Association International Conference on Alzheimer's Disease, 2009. In Alzheimer's & Dementia, 2009, v. 5 n. 4 Suppl, p. P397–P398en_HK
dc.identifier.issn1552-5260en_HK
dc.identifier.urihttp://hdl.handle.net/10722/61401-
dc.description.abstractBackground: Accumulating evidence indicates that abnormalities in tau protein play a critical role in the pathogenesis of Alzheimer's disease (AD). Endoplasmic reticulum (ER) stress has been implicated in pathological processes resulting in neuronal death in AD. However, the potential connection of tau abnormalities and ER stress was not explored. Methods: Immunofluorescence staining of phosphorylated tau (pT231) and ER stress markers PERK and CHOP was performed to determine any colocalization of phosphorylated tau and increased ER-stress markers in aged (22 months old) transgenic mice expressing the P301L mutated form of human tau. Furthermore, Western-blot analysis was used to detect the levels of BiP, one of ER stress markers, and phosphorylation of eIF2α. Results: Immunfluorescence analysis revealed that activation of PERK (increased phosphorylation of PERK) and increased expression of CHOP were observed in hippocampal neurons containing accumulation of phosphorylated tau in the aged transgenic mice. Western-blot analysis revealed that the levels of BiP and phosphorylation of eIF2α were significantly increased in the hippocampus of aged transgenic mice. Conclusions: Our data indicate that in addition to β-amyloid peptide, pathological tau can also induce ER stress, which can be involved in promoting neuronal loss (apoptosis) observed in this transgenic mouse model and AD cases.-
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.alzheimersanddementia.org/en_HK
dc.relation.ispartofAlzheimer's & Dementia-
dc.rightsAlzheimer's & Dementia. Copyright © Elsevier Inc.en_HK
dc.titleEndoplasmic reticulum stress in aged P301L Tau transgenic miceen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1552-5260&volume=5 Suppl 1&spage=P397 P3&epage=185&date=2009&atitle=Endoplasmic+reticulum+stress+in+aged+P301L+Tau+transgenic+miceen_HK
dc.identifier.emailYang, X: yangxifeismile@yahoo.com.cnen_HK
dc.identifier.emailChang, RCC: rccchang@hkucc.hku.hken_HK
dc.identifier.authorityChang, RCC=rp00470en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jalz.2009.04.1059-
dc.identifier.hkuros157762en_HK

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