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Conference Paper: Assessment of angiogenesis and osteogenesis in continuous distraction osteogenesis

TitleAssessment of angiogenesis and osteogenesis in continuous distraction osteogenesis
Authors
Issue Date2009
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/ijom
Citation
The 19th International Conference on Oral and Maxillofacial Surgery, Shanghai, China, 23-27 May 2009. In International Journal of Oral and Maxillofacial Surgery, 2009, v. 38 n. 5, p. 458, abstarct O5.9 How to Cite?
AbstractBACKGROUND AND OBJECTIVES: To evaluate the effect of distraction frequency on angiogenesis and osteogenesis using a rabbit model of mandibular lengthening. METHODS: 80 adult New Zealand white rabbits were randomly assigned to the continuous distraction group and intermittent distraction group. Unilaterally straight osteotomy was performed on all the animals. The custom-designed manual-driven or auto-driven distractor was adapted on the mandible. For the intermittent distraction group, distraction was performed once per day; in the continuous distraction group, distraction was achieved at a high frequency of 8 steps per second. 10 rabbits in each group were sacrificed at day 3, day 7, day 11 (end of active distraction) and day 18 (week 1 of consolidation) respectively. Bone healing were assessed by histological examination; angiogenesis was evaluated by the immunohistochemical staining of collagen IV; mRNA expression of vascular epithelial growth factor, basic fibroblast growth factor, bone morphogenetic growth factors, transforming growth factor-beta were examined by real time polymerase chain reaction (PCR). RESULTS: All rabbits completed the experimental process uneventfully. Real time PCR examination demonstrated a significant upregulation of all the angiogenic and osteogenic growth factors in the continuous distraction group. Neo-vessel density and bone formation in distraction regenerate was significantly increased by the high frequency traction. CONCLUSION: High frequency mechanical traction creates a superior biological environment for bone regeneration by upregulating angiogenic and osteogenic factors.
DescriptionThis journal issue entitled: Abstracts of the 19th International Conference on Oral and Maxillofacial Surgery 23-27 May 2009, Shanghai, China
Free Paper - Oral Presentations: no. O5.9
Persistent Identifierhttp://hdl.handle.net/10722/61376
ISSN
2015 Impact Factor: 1.563
2015 SCImago Journal Rankings: 0.854

 

DC FieldValueLanguage
dc.contributor.authorZheng, Len_HK
dc.contributor.authorMa, Len_HK
dc.contributor.authorCheung, LKen_HK
dc.date.accessioned2010-07-13T03:38:17Z-
dc.date.available2010-07-13T03:38:17Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 19th International Conference on Oral and Maxillofacial Surgery, Shanghai, China, 23-27 May 2009. In International Journal of Oral and Maxillofacial Surgery, 2009, v. 38 n. 5, p. 458, abstarct O5.9en_HK
dc.identifier.issn0901-5027en_HK
dc.identifier.urihttp://hdl.handle.net/10722/61376-
dc.descriptionThis journal issue entitled: Abstracts of the 19th International Conference on Oral and Maxillofacial Surgery 23-27 May 2009, Shanghai, China-
dc.descriptionFree Paper - Oral Presentations: no. O5.9-
dc.description.abstractBACKGROUND AND OBJECTIVES: To evaluate the effect of distraction frequency on angiogenesis and osteogenesis using a rabbit model of mandibular lengthening. METHODS: 80 adult New Zealand white rabbits were randomly assigned to the continuous distraction group and intermittent distraction group. Unilaterally straight osteotomy was performed on all the animals. The custom-designed manual-driven or auto-driven distractor was adapted on the mandible. For the intermittent distraction group, distraction was performed once per day; in the continuous distraction group, distraction was achieved at a high frequency of 8 steps per second. 10 rabbits in each group were sacrificed at day 3, day 7, day 11 (end of active distraction) and day 18 (week 1 of consolidation) respectively. Bone healing were assessed by histological examination; angiogenesis was evaluated by the immunohistochemical staining of collagen IV; mRNA expression of vascular epithelial growth factor, basic fibroblast growth factor, bone morphogenetic growth factors, transforming growth factor-beta were examined by real time polymerase chain reaction (PCR). RESULTS: All rabbits completed the experimental process uneventfully. Real time PCR examination demonstrated a significant upregulation of all the angiogenic and osteogenic growth factors in the continuous distraction group. Neo-vessel density and bone formation in distraction regenerate was significantly increased by the high frequency traction. CONCLUSION: High frequency mechanical traction creates a superior biological environment for bone regeneration by upregulating angiogenic and osteogenic factors.-
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/ijomen_HK
dc.relation.ispartofInternational Journal of Oral and Maxillofacial Surgery-
dc.titleAssessment of angiogenesis and osteogenesis in continuous distraction osteogenesisen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0901-5027&volume=May 38 &issue=5&spage=p 458 (O5.9)&epage=&date=2009&atitle=Assessment+of+angiogenesis+and+osteogenesis+in+continuous+distraction+osteogenesis++(Free+Paper+-+Oral+Presentations)en_HK
dc.identifier.emailZheng, L: zhengl@graduate.hku.hken_HK
dc.identifier.emailMa, L: mali210@hotmail.comen_HK
dc.identifier.emailCheung, LK: lkcheung@hkucc.hku.hken_HK
dc.identifier.authorityCheung, LK=rp00013en_HK
dc.identifier.doi10.1016/j.ijom.2009.03.219-
dc.identifier.hkuros156086en_HK
dc.identifier.volume38-
dc.identifier.issue5-
dc.identifier.spage458, abstarct O5.9-
dc.identifier.epage458, abstarct O5.9-

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