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Conference Paper: Assessment of angiogenesis and osteogenesis in continuous distraction osteogenesis
Title | Assessment of angiogenesis and osteogenesis in continuous distraction osteogenesis |
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Authors | |
Issue Date | 2009 |
Publisher | Churchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/ijom |
Citation | The 19th International Conference on Oral and Maxillofacial Surgery, Shanghai, China, 23-27 May 2009. In International Journal of Oral and Maxillofacial Surgery, 2009, v. 38 n. 5, p. 458, abstarct O5.9 How to Cite? |
Abstract | BACKGROUND AND OBJECTIVES: To evaluate the effect of distraction frequency on angiogenesis and osteogenesis using a rabbit model of mandibular lengthening. METHODS: 80 adult New Zealand white rabbits were randomly assigned to the continuous distraction group and intermittent distraction group. Unilaterally straight osteotomy was performed on all the animals. The custom-designed manual-driven or auto-driven distractor was adapted on the mandible. For the intermittent distraction group, distraction was performed once per day; in the continuous distraction group, distraction was achieved at a high frequency of 8 steps per second. 10 rabbits in each group were sacrificed at day 3, day 7, day 11 (end of active distraction) and day 18 (week 1 of consolidation) respectively. Bone healing were assessed by histological examination; angiogenesis was evaluated by the immunohistochemical staining of collagen IV; mRNA expression of vascular epithelial growth factor, basic fibroblast growth factor, bone morphogenetic growth factors, transforming growth factor-beta were examined by real time polymerase chain reaction (PCR). RESULTS: All rabbits completed the experimental process uneventfully. Real time PCR examination demonstrated a significant upregulation of all the angiogenic and osteogenic growth factors in the continuous distraction group. Neo-vessel density and bone formation in distraction regenerate was significantly increased by the high frequency traction. CONCLUSION: High frequency mechanical traction creates a superior biological environment for bone regeneration by upregulating angiogenic and osteogenic factors. |
Description | This journal issue entitled: Abstracts of the 19th International Conference on Oral and Maxillofacial Surgery 23-27 May 2009, Shanghai, China Free Paper - Oral Presentations: no. O5.9 |
Persistent Identifier | http://hdl.handle.net/10722/61376 |
ISSN | 2023 Impact Factor: 2.2 2023 SCImago Journal Rankings: 0.875 |
DC Field | Value | Language |
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dc.contributor.author | Zheng, L | en_HK |
dc.contributor.author | Ma, L | en_HK |
dc.contributor.author | Cheung, LK | en_HK |
dc.date.accessioned | 2010-07-13T03:38:17Z | - |
dc.date.available | 2010-07-13T03:38:17Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | The 19th International Conference on Oral and Maxillofacial Surgery, Shanghai, China, 23-27 May 2009. In International Journal of Oral and Maxillofacial Surgery, 2009, v. 38 n. 5, p. 458, abstarct O5.9 | en_HK |
dc.identifier.issn | 0901-5027 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/61376 | - |
dc.description | This journal issue entitled: Abstracts of the 19th International Conference on Oral and Maxillofacial Surgery 23-27 May 2009, Shanghai, China | - |
dc.description | Free Paper - Oral Presentations: no. O5.9 | - |
dc.description.abstract | BACKGROUND AND OBJECTIVES: To evaluate the effect of distraction frequency on angiogenesis and osteogenesis using a rabbit model of mandibular lengthening. METHODS: 80 adult New Zealand white rabbits were randomly assigned to the continuous distraction group and intermittent distraction group. Unilaterally straight osteotomy was performed on all the animals. The custom-designed manual-driven or auto-driven distractor was adapted on the mandible. For the intermittent distraction group, distraction was performed once per day; in the continuous distraction group, distraction was achieved at a high frequency of 8 steps per second. 10 rabbits in each group were sacrificed at day 3, day 7, day 11 (end of active distraction) and day 18 (week 1 of consolidation) respectively. Bone healing were assessed by histological examination; angiogenesis was evaluated by the immunohistochemical staining of collagen IV; mRNA expression of vascular epithelial growth factor, basic fibroblast growth factor, bone morphogenetic growth factors, transforming growth factor-beta were examined by real time polymerase chain reaction (PCR). RESULTS: All rabbits completed the experimental process uneventfully. Real time PCR examination demonstrated a significant upregulation of all the angiogenic and osteogenic growth factors in the continuous distraction group. Neo-vessel density and bone formation in distraction regenerate was significantly increased by the high frequency traction. CONCLUSION: High frequency mechanical traction creates a superior biological environment for bone regeneration by upregulating angiogenic and osteogenic factors. | - |
dc.language | eng | en_HK |
dc.publisher | Churchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/ijom | en_HK |
dc.relation.ispartof | International Journal of Oral and Maxillofacial Surgery | - |
dc.title | Assessment of angiogenesis and osteogenesis in continuous distraction osteogenesis | en_HK |
dc.type | Conference_Paper | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0901-5027&volume=May 38 &issue=5&spage=p 458 (O5.9)&epage=&date=2009&atitle=Assessment+of+angiogenesis+and+osteogenesis+in+continuous+distraction+osteogenesis++(Free+Paper+-+Oral+Presentations) | en_HK |
dc.identifier.email | Zheng, L: zhengl@graduate.hku.hk | en_HK |
dc.identifier.email | Ma, L: mali210@hotmail.com | en_HK |
dc.identifier.email | Cheung, LK: lkcheung@hkucc.hku.hk | en_HK |
dc.identifier.authority | Cheung, LK=rp00013 | en_HK |
dc.identifier.doi | 10.1016/j.ijom.2009.03.219 | - |
dc.identifier.hkuros | 156086 | en_HK |
dc.identifier.volume | 38 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 458, abstarct O5.9 | - |
dc.identifier.epage | 458, abstarct O5.9 | - |
dc.identifier.issnl | 0901-5027 | - |