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Conference Paper: How dose nicotine affect bone regeneration?

TitleHow dose nicotine affect bone regeneration?
Authors
Issue Date2008
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jcms
Citation
The 19th Congress of the European Association for Cranio-Maxillofacial Surgery, Bologna, Italy, 9-12 September 2008. In Journal of Cranio-Maxillofacial Surgery, 2008, v. 36 suppl. 1, p. S155, abstract O.619 How to Cite?
AbstractOBJECTIVE: To study the effect of nicotine on bone regeneration and neo-angiogenesis using a rabbit model of madibular lengthening and evaluate the influence of nicotine on the expression of osteogenesis and angiogenesis related growth factors in distraction regenerate. METHODS: 50 adult New Zealand white rabbits were randomly assigned to two equal groups: placebo control and 1.5g nicotine. 60-day time release nicotine pellets or placebo pellets were implanted in the neck subcutaneous tissue of the rabbits. Total nicotine exposure time was seven weeks. After nicotine implantation, a standard procedure of mandibular body osteotomy and distraction were performed. The animals were sacrificed at day 5 of distraction, day 1, week 1, week 2 and week 4 of consolidation. The madibles were harvested for the analysis of plain X-ray, micro-CT, Histological staining and real-time PCR. RESULTS: Nicotine exposure increased microvessel density, whereas inhibited blood flow and bone formation. Frequent appearance of cartilage islands suggested ischemia and low oxygen tension in the distraction regenerate. The expression of bone morphogenetic protein was decreased. The expression of vascular endothelial growth factor was increased. CONCLUSIONS: Nicotine compromises bone regeneration by causing ischemia and directly inhibitory effect on osteoblastic cells. Nicotine exposure enhances angiogenesis but can not compensate for the adverse effect of vasoconstriction.
DescriptionThis journal suppl. entitled: Abstracts from the XIXth Congress of the European Association for Cranio-Maxillofacial Surgery
Oral Presentation - Tissue engineering and cell therapy I: no. O.619
Persistent Identifierhttp://hdl.handle.net/10722/61293
ISSN
2015 Impact Factor: 1.592
2015 SCImago Journal Rankings: 1.010

 

DC FieldValueLanguage
dc.contributor.authorMa, Len_HK
dc.contributor.authorZheng, Len_HK
dc.contributor.authorCheung, LKen_HK
dc.date.accessioned2010-07-13T03:36:39Z-
dc.date.available2010-07-13T03:36:39Z-
dc.date.issued2008en_HK
dc.identifier.citationThe 19th Congress of the European Association for Cranio-Maxillofacial Surgery, Bologna, Italy, 9-12 September 2008. In Journal of Cranio-Maxillofacial Surgery, 2008, v. 36 suppl. 1, p. S155, abstract O.619en_HK
dc.identifier.issn1010-5182en_HK
dc.identifier.urihttp://hdl.handle.net/10722/61293-
dc.descriptionThis journal suppl. entitled: Abstracts from the XIXth Congress of the European Association for Cranio-Maxillofacial Surgery-
dc.descriptionOral Presentation - Tissue engineering and cell therapy I: no. O.619-
dc.description.abstractOBJECTIVE: To study the effect of nicotine on bone regeneration and neo-angiogenesis using a rabbit model of madibular lengthening and evaluate the influence of nicotine on the expression of osteogenesis and angiogenesis related growth factors in distraction regenerate. METHODS: 50 adult New Zealand white rabbits were randomly assigned to two equal groups: placebo control and 1.5g nicotine. 60-day time release nicotine pellets or placebo pellets were implanted in the neck subcutaneous tissue of the rabbits. Total nicotine exposure time was seven weeks. After nicotine implantation, a standard procedure of mandibular body osteotomy and distraction were performed. The animals were sacrificed at day 5 of distraction, day 1, week 1, week 2 and week 4 of consolidation. The madibles were harvested for the analysis of plain X-ray, micro-CT, Histological staining and real-time PCR. RESULTS: Nicotine exposure increased microvessel density, whereas inhibited blood flow and bone formation. Frequent appearance of cartilage islands suggested ischemia and low oxygen tension in the distraction regenerate. The expression of bone morphogenetic protein was decreased. The expression of vascular endothelial growth factor was increased. CONCLUSIONS: Nicotine compromises bone regeneration by causing ischemia and directly inhibitory effect on osteoblastic cells. Nicotine exposure enhances angiogenesis but can not compensate for the adverse effect of vasoconstriction.-
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/jcmsen_HK
dc.relation.ispartofJournal of Cranio-Maxillofacial Surgery-
dc.titleHow dose nicotine affect bone regeneration?en_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1010-5182&volume=36&spage=S155&epage=&date=2008&atitle=How+dose+nicotine+affect+bone+regeneration?+en_HK
dc.identifier.emailMa, L: mali210@hotmail.comen_HK
dc.identifier.emailZheng, L: zhengl@graduate.hku.hken_HK
dc.identifier.emailCheung, LK: lkcheung@hkucc.hku.hken_HK
dc.identifier.authorityCheung, LK=rp00013en_HK
dc.identifier.doi10.1016/S1010-5182(08)71743-8-
dc.identifier.hkuros158893en_HK
dc.identifier.volume36-
dc.identifier.issuesuppl. 1-
dc.identifier.spageS155, abstract O.619-
dc.identifier.epageS155, abstract O.619-

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