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Conference Paper: The genetic basis of a dentigerous cyst associated with a supernumerary tooth?

TitleThe genetic basis of a dentigerous cyst associated with a supernumerary tooth?
Authors
KeywordsMedical sciences
Dentistry
Issue Date2009
PublisherWiley-Blackwell Publishing Ltd..
Citation
The 22nd Congress of the International Association of Paediatric Dentistry, Munich, Germany, 17-20 June, 2009. In International Journal of Paediatric Dentistry, 2009, v. 19, suppl. s1, p. 32, abstract no: O12-89 How to Cite?
AbstractINTRODUCTION: Supernumerary teeth are teeth additional to the normal complement and the frequent clinical indicators are noneruption or delayed eruption of teeth, crowding, displacement and dentigerous cyst (DC) formation. Approximately, 95% of DCs involve the permanent dentition and only 5% are associated with supernumerary teeth. The objectives of this study were to: (i) report a pair of siblings with supernumeraries of whom, one developed a dentigerous cyst and (ii) analyze fragile histidine triad (FHIT) and p53 gene status in DC associated with supernumerary teeth. CLINICAL MANAGEMENT: This six-year-old Chinese boy complained of swelling in the maxillary right incisor region. Radiographs revealed the presence of two supernumeraries in the premaxillary region, one of which had evidence of an enlarged follicle. Histopathology confirmed that the cystic lining was consistent with a DC. The patients elder sister also exhibited two supernumeraries in the premaxilla which was subsequently surgically removed. Blood samples were collected and the DNA extracted using the Qiagen_ mini blood kit. The DNA yield was quantified using 260 nm/280 nm ratio. After isolation, aliquots of the DNA samples were prepared for analyzing the status of the FHIT and p53 gene. CONCLUSION: Occurrence of supernumerary teeth in siblings indicates that inheritance is a major contributory factor in their development. Although DCs are uncommon in the first decade of life, regular inspections of radiographs are important. It is hypothesized that aberrations of FHIT and p53 genes could be considered as markers responsible for the development of DCs associated with supernumerary teeth.
DescriptionOral Sessions - O12/Syndromes and Genetics 2
Persistent Identifierhttp://hdl.handle.net/10722/61259
ISSN
2015 SCImago Journal Rankings: 0.721

 

DC FieldValueLanguage
dc.contributor.authorAnthonappa, RPen_HK
dc.contributor.authorKing, NMen_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2010-07-13T03:35:58Z-
dc.date.available2010-07-13T03:35:58Z-
dc.date.issued2009en_HK
dc.identifier.citationThe 22nd Congress of the International Association of Paediatric Dentistry, Munich, Germany, 17-20 June, 2009. In International Journal of Paediatric Dentistry, 2009, v. 19, suppl. s1, p. 32, abstract no: O12-89en_HK
dc.identifier.issn1365-263X-
dc.identifier.urihttp://hdl.handle.net/10722/61259-
dc.descriptionOral Sessions - O12/Syndromes and Genetics 2-
dc.description.abstractINTRODUCTION: Supernumerary teeth are teeth additional to the normal complement and the frequent clinical indicators are noneruption or delayed eruption of teeth, crowding, displacement and dentigerous cyst (DC) formation. Approximately, 95% of DCs involve the permanent dentition and only 5% are associated with supernumerary teeth. The objectives of this study were to: (i) report a pair of siblings with supernumeraries of whom, one developed a dentigerous cyst and (ii) analyze fragile histidine triad (FHIT) and p53 gene status in DC associated with supernumerary teeth. CLINICAL MANAGEMENT: This six-year-old Chinese boy complained of swelling in the maxillary right incisor region. Radiographs revealed the presence of two supernumeraries in the premaxillary region, one of which had evidence of an enlarged follicle. Histopathology confirmed that the cystic lining was consistent with a DC. The patients elder sister also exhibited two supernumeraries in the premaxilla which was subsequently surgically removed. Blood samples were collected and the DNA extracted using the Qiagen_ mini blood kit. The DNA yield was quantified using 260 nm/280 nm ratio. After isolation, aliquots of the DNA samples were prepared for analyzing the status of the FHIT and p53 gene. CONCLUSION: Occurrence of supernumerary teeth in siblings indicates that inheritance is a major contributory factor in their development. Although DCs are uncommon in the first decade of life, regular inspections of radiographs are important. It is hypothesized that aberrations of FHIT and p53 genes could be considered as markers responsible for the development of DCs associated with supernumerary teeth.-
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Ltd..-
dc.relation.ispartofInternational Journal of Paediatric Dentistry-
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subjectMedical sciences-
dc.subjectDentistry-
dc.titleThe genetic basis of a dentigerous cyst associated with a supernumerary tooth?en_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1365-263X&volume=19&issue=suppl. s1&spage=32, abstract no: O12&epage=89&date=2009&atitle=The+genetic+basis+of+a+dentigerous+cyst+associated+with+a+supernumerary+tooth?-
dc.identifier.emailKing, NM: hhdbknm@hkucc.hku.hk, profnigelking@mac.comen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityKing, NM=rp00006en_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1365-263X.2009.00992_1.x-
dc.identifier.hkuros161643en_HK
dc.identifier.volume19-
dc.identifier.issuesuppl. s1-
dc.identifier.spage32-
dc.identifier.epage32-
dc.description.otherThe 22nd Congress of the International Association of Paediatric Dentistry, Munich, Germany, 17-20 June, 2009. In International Journal of Paediatric Dentistry, 2009, v. 19, suppl. s1, p. 32, abstract no: O12-89-

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