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Article: Remifentanil post-conditioning attenuates cardiac ischemia-reperfusion injury via κ or δ opioid receptor activation
Title | Remifentanil post-conditioning attenuates cardiac ischemia-reperfusion injury via κ or δ opioid receptor activation | ||||||
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Authors | |||||||
Issue Date | 2010 | ||||||
Publisher | Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AAS | ||||||
Citation | Acta Anaesthesiologica Scandinavica, 2010, v. 54 n. 4, p. 510-518 How to Cite? | ||||||
Abstract | Background: Ischemic pre- or post-conditioning of the heart has been shown to involve opioid receptors. Remifentanil, an ultra-short-acting selective μ opioid receptor agonist in clinical use, pre-conditions the rat heart against ischemia-reperfusion injury. This study investigates whether remifentanil post-conditioning is also cardioprotective. Methods: Remifentanil post-conditioning (5-min infusion at 1, 5, 10 or 20 μg/kg/min) or ischemic post-conditioning (three cycles of a 10 s reperfusion interspersed with a 10 s ischemia) was induced in an open-chest rat heart model of ischemia and reperfusion injury, in the presence or absence of nor-binaltorphimine, naltrindole or CTOP, specific κ, δ and μ opioid receptor antagonists, respectively. The same sequence of experiments was repeated in the isolated heart model using the maximal protective dose of remifentanil from the dose-response studies. Results: Both ischemic and remifentanil post-conditioning reduced the myocardial infarct size relative to the control group in both models. This cardioprotective effect for both post-conditioning regimes was prevented by the prior administration of nor-binaltorphimine and naltrindole but not CTOP. The sole administration of the antagonists had no effect on the size of myocardial infarction. Conclusions: These results indicate that remifentanil post-conditioning protects the heart from ischemia-reperfusion injury to a similar extent as of ischemic post-conditioning. This protection involves κ and δ but not μ opioid receptor activation. This drug has great potential as a clinical post-conditioning modality as it can be given in large doses without prolonged opioid-related side effects. © 2009 The Acta Anaesthesiologica Scandinavica Foundation. | ||||||
Persistent Identifier | http://hdl.handle.net/10722/60990 | ||||||
ISSN | 2023 Impact Factor: 1.9 2023 SCImago Journal Rankings: 0.743 | ||||||
ISI Accession Number ID |
Funding Information: This work was performed in the Department of Anaesthesiology, University of Hong Kong, and was funded in part by the Small Project Fund, University of Hong Kong. It has been presented in part at the Annual Scientific Meeting of the Australian and New Zealand College of Anaesthetists in Sydney, Australia, on 6 May 2008. | ||||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wong, GTC | en_HK |
dc.contributor.author | Li, R | en_HK |
dc.contributor.author | Jiang, LL | en_HK |
dc.contributor.author | Irwin, MG | en_HK |
dc.date.accessioned | 2010-06-03T04:23:02Z | - |
dc.date.available | 2010-06-03T04:23:02Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | Acta Anaesthesiologica Scandinavica, 2010, v. 54 n. 4, p. 510-518 | en_HK |
dc.identifier.issn | 0001-5172 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/60990 | - |
dc.description.abstract | Background: Ischemic pre- or post-conditioning of the heart has been shown to involve opioid receptors. Remifentanil, an ultra-short-acting selective μ opioid receptor agonist in clinical use, pre-conditions the rat heart against ischemia-reperfusion injury. This study investigates whether remifentanil post-conditioning is also cardioprotective. Methods: Remifentanil post-conditioning (5-min infusion at 1, 5, 10 or 20 μg/kg/min) or ischemic post-conditioning (three cycles of a 10 s reperfusion interspersed with a 10 s ischemia) was induced in an open-chest rat heart model of ischemia and reperfusion injury, in the presence or absence of nor-binaltorphimine, naltrindole or CTOP, specific κ, δ and μ opioid receptor antagonists, respectively. The same sequence of experiments was repeated in the isolated heart model using the maximal protective dose of remifentanil from the dose-response studies. Results: Both ischemic and remifentanil post-conditioning reduced the myocardial infarct size relative to the control group in both models. This cardioprotective effect for both post-conditioning regimes was prevented by the prior administration of nor-binaltorphimine and naltrindole but not CTOP. The sole administration of the antagonists had no effect on the size of myocardial infarction. Conclusions: These results indicate that remifentanil post-conditioning protects the heart from ischemia-reperfusion injury to a similar extent as of ischemic post-conditioning. This protection involves κ and δ but not μ opioid receptor activation. This drug has great potential as a clinical post-conditioning modality as it can be given in large doses without prolonged opioid-related side effects. © 2009 The Acta Anaesthesiologica Scandinavica Foundation. | en_HK |
dc.language | eng | - |
dc.publisher | Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/AAS | en_HK |
dc.relation.ispartof | Acta Anaesthesiologica Scandinavica | en_HK |
dc.rights | The definitive version is available at www.blackwell-synergy.com | - |
dc.subject.mesh | Analgesics, Opioid - pharmacology | - |
dc.subject.mesh | Cardiotonic Agents | - |
dc.subject.mesh | Myocardial Reperfusion Injury - drug therapy - pathology | - |
dc.subject.mesh | Receptors, Opioid, delta - agonists - antagonists and inhibitors | - |
dc.subject.mesh | Receptors, Opioid, kappa - agonists - antagonists and inhibitors | - |
dc.title | Remifentanil post-conditioning attenuates cardiac ischemia-reperfusion injury via κ or δ opioid receptor activation | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0001-5172&volume=54&issue=4&spage=510&epage=518&date=2010&atitle=Remifentanil+post-conditioning+attenuates+cardiac+Ischemia-reperfusion+injury+via+κ+or+δ+opioid++receptor+activation | - |
dc.identifier.email | Wong, GTC:gordon@hku.hk | en_HK |
dc.identifier.email | Irwin, MG:mgirwin@hku.hk | en_HK |
dc.identifier.authority | Wong, GTC=rp00523 | en_HK |
dc.identifier.authority | Irwin, MG=rp00390 | en_HK |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1111/j.1399-6576.2009.02145.x | en_HK |
dc.identifier.pmid | 19878098 | - |
dc.identifier.scopus | eid_2-s2.0-77649214410 | en_HK |
dc.identifier.hkuros | 169783 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77649214410&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 54 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 510 | en_HK |
dc.identifier.epage | 518 | en_HK |
dc.identifier.eissn | 1399-6576 | - |
dc.identifier.isi | WOS:000274932800019 | - |
dc.publisher.place | Denmark | en_HK |
dc.identifier.citeulike | 6822842 | - |
dc.identifier.issnl | 0001-5172 | - |