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Article: Phacoemulsification Versus Combined Phacotrabeculectomy in Medically Controlled Chronic Angle Closure Glaucoma with Cataract

TitlePhacoemulsification Versus Combined Phacotrabeculectomy in Medically Controlled Chronic Angle Closure Glaucoma with Cataract
Authors
Issue Date2008
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ophtha
Citation
Ophthalmology, 2008, v. 115 n. 12, p. 2167-2173.e2 How to Cite?
AbstractObjective: To compare phacoemulsification alone versus combined phacotrabeculectomy in medically controlled chronic angle closure glaucoma (CACG) with coexisting cataract. Design: Randomized clinical trial. Participants: Seventy-two medically controlled CACG eyes with coexisting cataract. Intervention: Recruited patients were randomized into group 1 (phacoemulsification alone) or group 2 (combined phacotrabeculectomy with adjunctive mitomycin C). Postoperatively, patients were reviewed every 3 months for 2 years. Main Outcome Measures: Intraocular pressure (IOP) and requirement for topical glaucoma drugs. Results: Thirty-five CACG eyes were randomized into group 1, and 37 CACG eyes were randomized into group 2. There were no statistically significant differences (P>0.05) in mean IOP between the 2 treatment groups preoperatively and postoperatively, except at 1 month (P = 0.001) and 3 months (P = 0.008). Combined phacotrabeculectomy with adjunctive mitomycin C resulted in 0.80 less topical glaucoma drugs (P<0.001) in the 24-month postoperative period compared with phacoemulsification alone. The differences in IOP control were, however, not associated with differences in glaucomatous progression. Combined surgery was associated with more postoperative (P<0.001) complications compared with phacoemulsification alone. Conclusions: Combined phacotrabeculectomy with adjunctive mitomycin C may be marginally more effective than phacoemulsification alone in controlling IOP in medically controlled CACG eyes with coexisting cataract. Combined surgery may be associated with more complications and additional surgery in the postoperative period. Further study is needed to determine whether the marginally better IOP control of combined surgery justifies the potential additional risks of complications and further surgery. Financial Disclosure(s): The authors have no proprietary or commercial interest in any materials discussed in this article. © 2008 American Academy of Ophthalmology.
Persistent Identifierhttp://hdl.handle.net/10722/60914
ISSN
2015 Impact Factor: 6.75
2015 SCImago Journal Rankings: 4.745
ISI Accession Number ID
Funding AgencyGrant Number
Chinese University of Hong Kong
Funding Information:

Financial support: Direct Grant for Research from the Chinese University of Hong Kong 2004-2005. The funding organization had no role in the design or conduct of this research.

References

 

DC FieldValueLanguage
dc.contributor.authorTham, CCYen_HK
dc.contributor.authorKwong, YYYen_HK
dc.contributor.authorLeung, DYLen_HK
dc.contributor.authorLam, SWen_HK
dc.contributor.authorLi, FCHen_HK
dc.contributor.authorChiu, TYHen_HK
dc.contributor.authorChan, JCHen_HK
dc.contributor.authorChan, CHYen_HK
dc.contributor.authorPoon, ASYen_HK
dc.contributor.authorYick, DWFen_HK
dc.contributor.authorChi, CCen_HK
dc.contributor.authorLam, DSCen_HK
dc.contributor.authorLai, JSMen_HK
dc.date.accessioned2010-05-31T04:21:43Z-
dc.date.available2010-05-31T04:21:43Z-
dc.date.issued2008en_HK
dc.identifier.citationOphthalmology, 2008, v. 115 n. 12, p. 2167-2173.e2en_HK
dc.identifier.issn0161-6420en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60914-
dc.description.abstractObjective: To compare phacoemulsification alone versus combined phacotrabeculectomy in medically controlled chronic angle closure glaucoma (CACG) with coexisting cataract. Design: Randomized clinical trial. Participants: Seventy-two medically controlled CACG eyes with coexisting cataract. Intervention: Recruited patients were randomized into group 1 (phacoemulsification alone) or group 2 (combined phacotrabeculectomy with adjunctive mitomycin C). Postoperatively, patients were reviewed every 3 months for 2 years. Main Outcome Measures: Intraocular pressure (IOP) and requirement for topical glaucoma drugs. Results: Thirty-five CACG eyes were randomized into group 1, and 37 CACG eyes were randomized into group 2. There were no statistically significant differences (P>0.05) in mean IOP between the 2 treatment groups preoperatively and postoperatively, except at 1 month (P = 0.001) and 3 months (P = 0.008). Combined phacotrabeculectomy with adjunctive mitomycin C resulted in 0.80 less topical glaucoma drugs (P<0.001) in the 24-month postoperative period compared with phacoemulsification alone. The differences in IOP control were, however, not associated with differences in glaucomatous progression. Combined surgery was associated with more postoperative (P<0.001) complications compared with phacoemulsification alone. Conclusions: Combined phacotrabeculectomy with adjunctive mitomycin C may be marginally more effective than phacoemulsification alone in controlling IOP in medically controlled CACG eyes with coexisting cataract. Combined surgery may be associated with more complications and additional surgery in the postoperative period. Further study is needed to determine whether the marginally better IOP control of combined surgery justifies the potential additional risks of complications and further surgery. Financial Disclosure(s): The authors have no proprietary or commercial interest in any materials discussed in this article. © 2008 American Academy of Ophthalmology.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ophthaen_HK
dc.relation.ispartofOphthalmologyen_HK
dc.rightsOphthalmology. Copyright © Elsevier Inc.en_HK
dc.titlePhacoemulsification Versus Combined Phacotrabeculectomy in Medically Controlled Chronic Angle Closure Glaucoma with Cataracten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0161-6420&volume=&spage=2167&epage=2173&date=2008&atitle=Phacoemulsification+versus+combined+phacotrabeculectomy+in+medically+controlled+chronic+angle+closure+glaucoma+with+cataracten_HK
dc.identifier.emailLai, JSM: laism@hku.hken_HK
dc.identifier.authorityLai, JSM=rp00295en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ophtha.2008.06.016en_HK
dc.identifier.pmid18801576-
dc.identifier.scopuseid_2-s2.0-56549104345en_HK
dc.identifier.hkuros165632en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-56549104345&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume115en_HK
dc.identifier.issue12en_HK
dc.identifier.spage2167en_HK
dc.identifier.epage2173.e2en_HK
dc.identifier.eissn1549-4713-
dc.identifier.isiWOS:000261548200008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTham, CCY=7006081241en_HK
dc.identifier.scopusauthoridKwong, YYY=8614665700en_HK
dc.identifier.scopusauthoridLeung, DYL=13309931100en_HK
dc.identifier.scopusauthoridLam, SW=7402279310en_HK
dc.identifier.scopusauthoridLi, FCH=24779764500en_HK
dc.identifier.scopusauthoridChiu, TYH=7202210389en_HK
dc.identifier.scopusauthoridChan, JCH=26024354100en_HK
dc.identifier.scopusauthoridChan, CHY=27171187300en_HK
dc.identifier.scopusauthoridPoon, ASY=7103068842en_HK
dc.identifier.scopusauthoridYick, DWF=6507461286en_HK
dc.identifier.scopusauthoridChi, CC=36983431700en_HK
dc.identifier.scopusauthoridLam, DSC=35500200200en_HK
dc.identifier.scopusauthoridLai, JSM=7401939748en_HK

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