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Article: Phacoemulsification versus Combined Phacotrabeculectomy in Medically Uncontrolled Chronic Angle Closure Glaucoma with Cataracts

TitlePhacoemulsification versus Combined Phacotrabeculectomy in Medically Uncontrolled Chronic Angle Closure Glaucoma with Cataracts
Authors
Issue Date2009
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ophtha
Citation
Ophthalmology, 2009, v. 116 n. 4, p. 725-731.e3 How to Cite?
AbstractObjective: To compare phacoemulsification alone versus combined phacotrabeculectomy in medically uncontrolled chronic angle closure glaucoma (CACG) with coexisting cataract. Design: Prospective randomized clinical trial. Participants: Fifty-one medically uncontrolled CACG eyes with coexisting cataract of 51 patients. Intervention: Recruited patients were randomized into group 1 (phacoemulsification alone) or group 2 (combined phacotrabeculectomy with adjunctive mitomycin C). Postoperatively, patients were reviewed every 3 months for 2 years. Main Outcome Measures: Intraocular pressure (IOP) and requirement for topical glaucoma drugs. Results: Twenty-seven CACG eyes were randomized into group 1, and 24 CACG eyes were randomized into group 2. Combined phacotrabeculectomy resulted in lower mean postoperative IOP than phacoemulsification alone at 3 months (14.0 vs. 17.0 mmHg, P = 0.01), 15 months (13.2 vs. 15.4 mmHg, P = 0.02), and 18 months (13.6 vs. 15.9 mmHg, P = 0.01). Combined phacotrabeculectomy resulted in 1.25 fewer topical glaucoma drugs (P<0.001) in the 24-month postoperative period, compared with phacoemulsification alone. Combined surgery was associated with more postoperative complications (P<0.001) and more progression of optic neuropathy (P = 0.03), compared with phacoemulsification alone. Conclusions: Combined phacotrabeculectomy with adjunctive mitomycin C is more effective than phacoemulsification alone in controlling IOP in medically uncontrolled CACG eyes with coexisting cataract. Combined phacotrabeculectomy is associated with more postoperative complications. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. © 2009 American Academy of Ophthalmology.
Persistent Identifierhttp://hdl.handle.net/10722/60904
ISSN
2015 Impact Factor: 6.75
2015 SCImago Journal Rankings: 4.745
ISI Accession Number ID
Funding AgencyGrant Number
Chinese University of Hong Kong 2004-2005
Funding Information:

Supported by a Direct Grant for Research from the Chinese University of Hong Kong 2004-2005. The funding organization had no role in the design or conduct of this research.

References

 

DC FieldValueLanguage
dc.contributor.authorTham, CCYen_HK
dc.contributor.authorKwong, YYYen_HK
dc.contributor.authorLeung, DYLen_HK
dc.contributor.authorLam, SWen_HK
dc.contributor.authorLi, FCHen_HK
dc.contributor.authorChiu, TYHen_HK
dc.contributor.authorChan, JCHen_HK
dc.contributor.authorLam, DSCen_HK
dc.contributor.authorLai, JSMen_HK
dc.date.accessioned2010-05-31T04:21:31Z-
dc.date.available2010-05-31T04:21:31Z-
dc.date.issued2009en_HK
dc.identifier.citationOphthalmology, 2009, v. 116 n. 4, p. 725-731.e3en_HK
dc.identifier.issn0161-6420en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60904-
dc.description.abstractObjective: To compare phacoemulsification alone versus combined phacotrabeculectomy in medically uncontrolled chronic angle closure glaucoma (CACG) with coexisting cataract. Design: Prospective randomized clinical trial. Participants: Fifty-one medically uncontrolled CACG eyes with coexisting cataract of 51 patients. Intervention: Recruited patients were randomized into group 1 (phacoemulsification alone) or group 2 (combined phacotrabeculectomy with adjunctive mitomycin C). Postoperatively, patients were reviewed every 3 months for 2 years. Main Outcome Measures: Intraocular pressure (IOP) and requirement for topical glaucoma drugs. Results: Twenty-seven CACG eyes were randomized into group 1, and 24 CACG eyes were randomized into group 2. Combined phacotrabeculectomy resulted in lower mean postoperative IOP than phacoemulsification alone at 3 months (14.0 vs. 17.0 mmHg, P = 0.01), 15 months (13.2 vs. 15.4 mmHg, P = 0.02), and 18 months (13.6 vs. 15.9 mmHg, P = 0.01). Combined phacotrabeculectomy resulted in 1.25 fewer topical glaucoma drugs (P<0.001) in the 24-month postoperative period, compared with phacoemulsification alone. Combined surgery was associated with more postoperative complications (P<0.001) and more progression of optic neuropathy (P = 0.03), compared with phacoemulsification alone. Conclusions: Combined phacotrabeculectomy with adjunctive mitomycin C is more effective than phacoemulsification alone in controlling IOP in medically uncontrolled CACG eyes with coexisting cataract. Combined phacotrabeculectomy is associated with more postoperative complications. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. © 2009 American Academy of Ophthalmology.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ophthaen_HK
dc.relation.ispartofOphthalmologyen_HK
dc.rightsOphthalmology. Copyright © Elsevier Inc.en_HK
dc.titlePhacoemulsification versus Combined Phacotrabeculectomy in Medically Uncontrolled Chronic Angle Closure Glaucoma with Cataractsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0161-6420&volume=&spage=725&epage=731&date=2009&atitle=Phacoemulsification+versus+phacotrabeculectomy+in+medically+uncontrolled+chronic+angle+closure+glaucoma+with+cataracten_HK
dc.identifier.emailLai, JSM: laism@hku.hken_HK
dc.identifier.authorityLai, JSM=rp00295en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ophtha.2008.12.054en_HK
dc.identifier.pmid19243831-
dc.identifier.scopuseid_2-s2.0-63149171080en_HK
dc.identifier.hkuros165634en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-63149171080&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume116en_HK
dc.identifier.issue4en_HK
dc.identifier.spage725en_HK
dc.identifier.epage731.e3en_HK
dc.identifier.eissn1549-4713-
dc.identifier.isiWOS:000264814600018-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTham, CCY=7006081241en_HK
dc.identifier.scopusauthoridKwong, YYY=8614665700en_HK
dc.identifier.scopusauthoridLeung, DYL=13309931100en_HK
dc.identifier.scopusauthoridLam, SW=7402279310en_HK
dc.identifier.scopusauthoridLi, FCH=24779764500en_HK
dc.identifier.scopusauthoridChiu, TYH=7202210389en_HK
dc.identifier.scopusauthoridChan, JCH=26024354100en_HK
dc.identifier.scopusauthoridLam, DSC=35500200200en_HK
dc.identifier.scopusauthoridLai, JSM=7401939748en_HK
dc.identifier.citeulike4350016-

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