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Article: Quetiapine ameliorates anxiety-like behavior and cognitive impairments in stressed rats: Implications for the treatment of posttraumatic stress disorder
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TitleQuetiapine ameliorates anxiety-like behavior and cognitive impairments in stressed rats: Implications for the treatment of posttraumatic stress disorder
 
AuthorsWang, HN1
Peng, Y1
Tan, QR1
Chen, YC1
Zhang, RG1
Qiao, YT1
Wang, HH1
Liu, L3
Kuang, F3
Wang, BR3
Zhang, ZJ2
 
KeywordsAnxiety
Cognitive impairment
ERK
PTSD
Quetiapine
 
Issue Date2010
 
PublisherAkademie Ved Ceske Republiky, Fyziologicky Ustav. The Journal's web site is located at http://www.biomed.cas.cz/physiolres
 
CitationPhysiological Research, 2010, v. 59 n. 2, p. 263-271 [How to Cite?]
 
AbstractThe purpose of this study was to determine preventive and protective effects of chronic orally administration with quetiapine (QUE) against anxiety-like behavior and cognitive impairments in rats exposed to the enhanced single prolonged stress (ESPS), an animal model that is used to study post-traumatic stress disorder (PTSD), and to detect changes in the expression of cortical phosphorylated p44/42 extracellular-regulated protein kinase (pERK1/2). Before or after exposure to ESPS paradigm, consisting of 2-h constraint, 20-min forced swimming, etherinduced loss of consciousness, and an electric foot shock, rats were given orally QUE (10 mg/kg daily) for 14 days. Animals were then tested in the open field (OF), elevated plus-maze (EPM), and Morris water maze (MWM). Brains were removed for immunohistochemical staining of pERK1/2. ESPS exposure resulted in pronounced anxiety-like behavior compared to unexposed animals. ESPS-exposed animals also displayed marked learning and spatial memory impairments. However, QUE treatment (both before and after ESPS exposure) significantly ameliorated anxiety-like behavior, learning and spatial memory impairments. ESPS also markedly reduced the expression of pERK1/2 in the prefrontal cortex, medial amygdala nucleus, and cingulate gyrus. Both before and after ESPS exposure QUE treatments significantly elevated the reduced pERK1/2 expression in the three brain regions. QUE has preventive and protective effects against stress-associated symptoms and the changes in pERK1/2 functions may be associated with the pathophysiology of traumatic stress and the therapeutic efficacy of anti-PTSD therapy. © 2010 Institute of Physiology v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic.
 
ISSN0862-8408
2013 Impact Factor: 1.487
 
ISI Accession Number IDWOS:000278016200014
Funding AgencyGrant Number
Natural Science Foundation of China30670758/30870886
30700259
30670666
Military Medicine Foundations06G096
Funding Information:

This work was supported by grants from the Natural Science Foundation of China (No. 30670758/30870886 to QR Tan, No. 30700259 to YC Chen, and No. 30670666 to BR Wang), and the 11th Five-Year Project of Military Medicine Foundations (06G096 to Dr. QR Tan).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWang, HN
 
dc.contributor.authorPeng, Y
 
dc.contributor.authorTan, QR
 
dc.contributor.authorChen, YC
 
dc.contributor.authorZhang, RG
 
dc.contributor.authorQiao, YT
 
dc.contributor.authorWang, HH
 
dc.contributor.authorLiu, L
 
dc.contributor.authorKuang, F
 
dc.contributor.authorWang, BR
 
dc.contributor.authorZhang, ZJ
 
dc.date.accessioned2010-05-31T04:18:40Z
 
dc.date.available2010-05-31T04:18:40Z
 
dc.date.issued2010
 
dc.description.abstractThe purpose of this study was to determine preventive and protective effects of chronic orally administration with quetiapine (QUE) against anxiety-like behavior and cognitive impairments in rats exposed to the enhanced single prolonged stress (ESPS), an animal model that is used to study post-traumatic stress disorder (PTSD), and to detect changes in the expression of cortical phosphorylated p44/42 extracellular-regulated protein kinase (pERK1/2). Before or after exposure to ESPS paradigm, consisting of 2-h constraint, 20-min forced swimming, etherinduced loss of consciousness, and an electric foot shock, rats were given orally QUE (10 mg/kg daily) for 14 days. Animals were then tested in the open field (OF), elevated plus-maze (EPM), and Morris water maze (MWM). Brains were removed for immunohistochemical staining of pERK1/2. ESPS exposure resulted in pronounced anxiety-like behavior compared to unexposed animals. ESPS-exposed animals also displayed marked learning and spatial memory impairments. However, QUE treatment (both before and after ESPS exposure) significantly ameliorated anxiety-like behavior, learning and spatial memory impairments. ESPS also markedly reduced the expression of pERK1/2 in the prefrontal cortex, medial amygdala nucleus, and cingulate gyrus. Both before and after ESPS exposure QUE treatments significantly elevated the reduced pERK1/2 expression in the three brain regions. QUE has preventive and protective effects against stress-associated symptoms and the changes in pERK1/2 functions may be associated with the pathophysiology of traumatic stress and the therapeutic efficacy of anti-PTSD therapy. © 2010 Institute of Physiology v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationPhysiological Research, 2010, v. 59 n. 2, p. 263-271 [How to Cite?]
 
dc.identifier.epage271
 
dc.identifier.hkuros160162
 
dc.identifier.isiWOS:000278016200014
Funding AgencyGrant Number
Natural Science Foundation of China30670758/30870886
30700259
30670666
Military Medicine Foundations06G096
Funding Information:

This work was supported by grants from the Natural Science Foundation of China (No. 30670758/30870886 to QR Tan, No. 30700259 to YC Chen, and No. 30670666 to BR Wang), and the 11th Five-Year Project of Military Medicine Foundations (06G096 to Dr. QR Tan).

 
dc.identifier.issn0862-8408
2013 Impact Factor: 1.487
 
dc.identifier.issue2
 
dc.identifier.pmid19537923
 
dc.identifier.scopuseid_2-s2.0-77953932094
 
dc.identifier.spage263
 
dc.identifier.urihttp://hdl.handle.net/10722/60792
 
dc.identifier.volume59
 
dc.languageeng
 
dc.publisherAkademie Ved Ceske Republiky, Fyziologicky Ustav. The Journal's web site is located at http://www.biomed.cas.cz/physiolres
 
dc.publisher.placeCzech Republic
 
dc.relation.ispartofPhysiological Research
 
dc.relation.referencesReferences in Scopus
 
dc.subjectAnxiety
 
dc.subjectCognitive impairment
 
dc.subjectERK
 
dc.subjectPTSD
 
dc.subjectQuetiapine
 
dc.titleQuetiapine ameliorates anxiety-like behavior and cognitive impairments in stressed rats: Implications for the treatment of posttraumatic stress disorder
 
dc.typeArticle
 
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<contributor.author>Zhang, RG</contributor.author>
<contributor.author>Qiao, YT</contributor.author>
<contributor.author>Wang, HH</contributor.author>
<contributor.author>Liu, L</contributor.author>
<contributor.author>Kuang, F</contributor.author>
<contributor.author>Wang, BR</contributor.author>
<contributor.author>Zhang, ZJ</contributor.author>
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Author Affiliations
  1. Xijing Hospital
  2. The University of Hong Kong
  3. The Fourth Military Medical University