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Article: Quetiapine ameliorates anxiety-like behavior and cognitive impairments in stressed rats: Implications for the treatment of posttraumatic stress disorder

TitleQuetiapine ameliorates anxiety-like behavior and cognitive impairments in stressed rats: Implications for the treatment of posttraumatic stress disorder
Authors
KeywordsAnxiety
Cognitive impairment
ERK
PTSD
Quetiapine
Issue Date2010
PublisherAkademie Ved Ceske Republiky, Fyziologicky Ustav. The Journal's web site is located at http://www.biomed.cas.cz/physiolres
Citation
Physiological Research, 2010, v. 59 n. 2, p. 263-271 How to Cite?
Abstract
The purpose of this study was to determine preventive and protective effects of chronic orally administration with quetiapine (QUE) against anxiety-like behavior and cognitive impairments in rats exposed to the enhanced single prolonged stress (ESPS), an animal model that is used to study post-traumatic stress disorder (PTSD), and to detect changes in the expression of cortical phosphorylated p44/42 extracellular-regulated protein kinase (pERK1/2). Before or after exposure to ESPS paradigm, consisting of 2-h constraint, 20-min forced swimming, etherinduced loss of consciousness, and an electric foot shock, rats were given orally QUE (10 mg/kg daily) for 14 days. Animals were then tested in the open field (OF), elevated plus-maze (EPM), and Morris water maze (MWM). Brains were removed for immunohistochemical staining of pERK1/2. ESPS exposure resulted in pronounced anxiety-like behavior compared to unexposed animals. ESPS-exposed animals also displayed marked learning and spatial memory impairments. However, QUE treatment (both before and after ESPS exposure) significantly ameliorated anxiety-like behavior, learning and spatial memory impairments. ESPS also markedly reduced the expression of pERK1/2 in the prefrontal cortex, medial amygdala nucleus, and cingulate gyrus. Both before and after ESPS exposure QUE treatments significantly elevated the reduced pERK1/2 expression in the three brain regions. QUE has preventive and protective effects against stress-associated symptoms and the changes in pERK1/2 functions may be associated with the pathophysiology of traumatic stress and the therapeutic efficacy of anti-PTSD therapy. © 2010 Institute of Physiology v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic.
Persistent Identifierhttp://hdl.handle.net/10722/60792
ISSN
2013 Impact Factor: 1.487
ISI Accession Number ID
Funding AgencyGrant Number
Natural Science Foundation of China30670758/30870886
30700259
30670666
Military Medicine Foundations06G096
Funding Information:

This work was supported by grants from the Natural Science Foundation of China (No. 30670758/30870886 to QR Tan, No. 30700259 to YC Chen, and No. 30670666 to BR Wang), and the 11th Five-Year Project of Military Medicine Foundations (06G096 to Dr. QR Tan).

References

 

Author Affiliations
  1. Xijing Hospital
  2. The University of Hong Kong
  3. The Fourth Military Medical University
DC FieldValueLanguage
dc.contributor.authorWang, HNen_HK
dc.contributor.authorPeng, Yen_HK
dc.contributor.authorTan, QRen_HK
dc.contributor.authorChen, YCen_HK
dc.contributor.authorZhang, RGen_HK
dc.contributor.authorQiao, YTen_HK
dc.contributor.authorWang, HHen_HK
dc.contributor.authorLiu, Len_HK
dc.contributor.authorKuang, Fen_HK
dc.contributor.authorWang, BRen_HK
dc.contributor.authorZhang, ZJen_HK
dc.date.accessioned2010-05-31T04:18:40Z-
dc.date.available2010-05-31T04:18:40Z-
dc.date.issued2010en_HK
dc.identifier.citationPhysiological Research, 2010, v. 59 n. 2, p. 263-271en_HK
dc.identifier.issn0862-8408en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60792-
dc.description.abstractThe purpose of this study was to determine preventive and protective effects of chronic orally administration with quetiapine (QUE) against anxiety-like behavior and cognitive impairments in rats exposed to the enhanced single prolonged stress (ESPS), an animal model that is used to study post-traumatic stress disorder (PTSD), and to detect changes in the expression of cortical phosphorylated p44/42 extracellular-regulated protein kinase (pERK1/2). Before or after exposure to ESPS paradigm, consisting of 2-h constraint, 20-min forced swimming, etherinduced loss of consciousness, and an electric foot shock, rats were given orally QUE (10 mg/kg daily) for 14 days. Animals were then tested in the open field (OF), elevated plus-maze (EPM), and Morris water maze (MWM). Brains were removed for immunohistochemical staining of pERK1/2. ESPS exposure resulted in pronounced anxiety-like behavior compared to unexposed animals. ESPS-exposed animals also displayed marked learning and spatial memory impairments. However, QUE treatment (both before and after ESPS exposure) significantly ameliorated anxiety-like behavior, learning and spatial memory impairments. ESPS also markedly reduced the expression of pERK1/2 in the prefrontal cortex, medial amygdala nucleus, and cingulate gyrus. Both before and after ESPS exposure QUE treatments significantly elevated the reduced pERK1/2 expression in the three brain regions. QUE has preventive and protective effects against stress-associated symptoms and the changes in pERK1/2 functions may be associated with the pathophysiology of traumatic stress and the therapeutic efficacy of anti-PTSD therapy. © 2010 Institute of Physiology v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic.en_HK
dc.languageengen_HK
dc.publisherAkademie Ved Ceske Republiky, Fyziologicky Ustav. The Journal's web site is located at http://www.biomed.cas.cz/physiolresen_HK
dc.relation.ispartofPhysiological Researchen_HK
dc.subjectAnxietyen_HK
dc.subjectCognitive impairmenten_HK
dc.subjectERKen_HK
dc.subjectPTSDen_HK
dc.subjectQuetiapineen_HK
dc.titleQuetiapine ameliorates anxiety-like behavior and cognitive impairments in stressed rats: Implications for the treatment of posttraumatic stress disorderen_HK
dc.typeArticleen_HK
dc.identifier.emailZhang, ZJ: zhangzj@hkucc.hku.hken_HK
dc.identifier.authorityZhang, ZJ=rp01297en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid19537923en_HK
dc.identifier.scopuseid_2-s2.0-77953932094en_HK
dc.identifier.hkuros160162en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953932094&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume59en_HK
dc.identifier.issue2en_HK
dc.identifier.spage263en_HK
dc.identifier.epage271en_HK
dc.identifier.isiWOS:000278016200014-
dc.publisher.placeCzech Republicen_HK
dc.identifier.scopusauthoridWang, HN=7501732342en_HK
dc.identifier.scopusauthoridPeng, Y=34870185600en_HK
dc.identifier.scopusauthoridTan, QR=7102120177en_HK
dc.identifier.scopusauthoridChen, YC=24775181700en_HK
dc.identifier.scopusauthoridZhang, RG=7404864877en_HK
dc.identifier.scopusauthoridQiao, YT=26650169400en_HK
dc.identifier.scopusauthoridWang, HH=10144885500en_HK
dc.identifier.scopusauthoridLiu, L=35211019300en_HK
dc.identifier.scopusauthoridKuang, F=6602241329en_HK
dc.identifier.scopusauthoridWang, BR=7405917235en_HK
dc.identifier.scopusauthoridZhang, ZJ=8061473900en_HK

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