Article: Quetiapine ameliorates anxiety-like behavior and cognitive impairments in stressed rats: Implications for the treatment of posttraumatic stress disorder
| Title | Quetiapine ameliorates anxiety-like behavior and cognitive impairments in stressed rats: Implications for the treatment of posttraumatic stress disorder | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Wang, HN1 Peng, Y1 Tan, QR1 Chen, YC1 Zhang, RG1 Qiao, YT1 Wang, HH1 Liu, L3 Kuang, F3 Wang, BR3 Zhang, ZJ2 | ||||||
| Keywords | Anxiety Cognitive impairment ERK PTSD Quetiapine | ||||||
| Issue Date | 2010 | ||||||
| Publisher | Akademie Ved Ceske Republiky, Fyziologicky Ustav. The Journal's web site is located at http://www.biomed.cas.cz/physiolres | ||||||
| Citation | Physiological Research, 2010, v. 59 n. 2, p. 263-271 [How to Cite?] | ||||||
| Abstract | The purpose of this study was to determine preventive and protective effects of chronic orally administration with quetiapine (QUE) against anxiety-like behavior and cognitive impairments in rats exposed to the enhanced single prolonged stress (ESPS), an animal model that is used to study post-traumatic stress disorder (PTSD), and to detect changes in the expression of cortical phosphorylated p44/42 extracellular-regulated protein kinase (pERK1/2). Before or after exposure to ESPS paradigm, consisting of 2-h constraint, 20-min forced swimming, etherinduced loss of consciousness, and an electric foot shock, rats were given orally QUE (10 mg/kg daily) for 14 days. Animals were then tested in the open field (OF), elevated plus-maze (EPM), and Morris water maze (MWM). Brains were removed for immunohistochemical staining of pERK1/2. ESPS exposure resulted in pronounced anxiety-like behavior compared to unexposed animals. ESPS-exposed animals also displayed marked learning and spatial memory impairments. However, QUE treatment (both before and after ESPS exposure) significantly ameliorated anxiety-like behavior, learning and spatial memory impairments. ESPS also markedly reduced the expression of pERK1/2 in the prefrontal cortex, medial amygdala nucleus, and cingulate gyrus. Both before and after ESPS exposure QUE treatments significantly elevated the reduced pERK1/2 expression in the three brain regions. QUE has preventive and protective effects against stress-associated symptoms and the changes in pERK1/2 functions may be associated with the pathophysiology of traumatic stress and the therapeutic efficacy of anti-PTSD therapy. © 2010 Institute of Physiology v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic. | ||||||
| ISSN | 0862-8408 2011 Impact Factor: 1.555 2011 SCImago Journal Rankings: 0.091 | ||||||
| ISI Accession Number ID | WOS:000278016200014
Funding Information: This work was supported by grants from the Natural Science Foundation of China (No. 30670758/30870886 to QR Tan, No. 30700259 to YC Chen, and No. 30670666 to BR Wang), and the 11th Five-Year Project of Military Medicine Foundations (06G096 to Dr. QR Tan). | ||||||
| References | References in Scopus |
| dc.contributor.author | Wang, HN | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Peng, Y | ||||||
| dc.contributor.author | Tan, QR | ||||||
| dc.contributor.author | Chen, YC | ||||||
| dc.contributor.author | Zhang, RG | ||||||
| dc.contributor.author | Qiao, YT | ||||||
| dc.contributor.author | Wang, HH | ||||||
| dc.contributor.author | Liu, L | ||||||
| dc.contributor.author | Kuang, F | ||||||
| dc.contributor.author | Wang, BR | ||||||
| dc.contributor.author | Zhang, ZJ | ||||||
| dc.date.accessioned | 2010-05-31T04:18:40Z | ||||||
| dc.date.available | 2010-05-31T04:18:40Z | ||||||
| dc.date.issued | 2010 | ||||||
| dc.description.abstract | The purpose of this study was to determine preventive and protective effects of chronic orally administration with quetiapine (QUE) against anxiety-like behavior and cognitive impairments in rats exposed to the enhanced single prolonged stress (ESPS), an animal model that is used to study post-traumatic stress disorder (PTSD), and to detect changes in the expression of cortical phosphorylated p44/42 extracellular-regulated protein kinase (pERK1/2). Before or after exposure to ESPS paradigm, consisting of 2-h constraint, 20-min forced swimming, etherinduced loss of consciousness, and an electric foot shock, rats were given orally QUE (10 mg/kg daily) for 14 days. Animals were then tested in the open field (OF), elevated plus-maze (EPM), and Morris water maze (MWM). Brains were removed for immunohistochemical staining of pERK1/2. ESPS exposure resulted in pronounced anxiety-like behavior compared to unexposed animals. ESPS-exposed animals also displayed marked learning and spatial memory impairments. However, QUE treatment (both before and after ESPS exposure) significantly ameliorated anxiety-like behavior, learning and spatial memory impairments. ESPS also markedly reduced the expression of pERK1/2 in the prefrontal cortex, medial amygdala nucleus, and cingulate gyrus. Both before and after ESPS exposure QUE treatments significantly elevated the reduced pERK1/2 expression in the three brain regions. QUE has preventive and protective effects against stress-associated symptoms and the changes in pERK1/2 functions may be associated with the pathophysiology of traumatic stress and the therapeutic efficacy of anti-PTSD therapy. © 2010 Institute of Physiology v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic. | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | Physiological Research, 2010, v. 59 n. 2, p. 263-271 [How to Cite?] | ||||||
| dc.identifier.epage | 271 | ||||||
| dc.identifier.hkuros | 160162 | ||||||
| dc.identifier.isi | WOS:000278016200014
Funding Information: This work was supported by grants from the Natural Science Foundation of China (No. 30670758/30870886 to QR Tan, No. 30700259 to YC Chen, and No. 30670666 to BR Wang), and the 11th Five-Year Project of Military Medicine Foundations (06G096 to Dr. QR Tan). | ||||||
| dc.identifier.issn | 0862-8408 2011 Impact Factor: 1.555 2011 SCImago Journal Rankings: 0.091 | ||||||
| dc.identifier.issue | 2 | ||||||
| dc.identifier.pmid | 19537923 | ||||||
| dc.identifier.scopus | eid_2-s2.0-77953932094 | ||||||
| dc.identifier.spage | 263 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/60792 | ||||||
| dc.identifier.volume | 59 | ||||||
| dc.language | eng | ||||||
| dc.publisher | Akademie Ved Ceske Republiky, Fyziologicky Ustav. The Journal's web site is located at http://www.biomed.cas.cz/physiolres | ||||||
| dc.publisher.place | Czech Republic | ||||||
| dc.relation.ispartof | Physiological Research | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.subject | Anxiety | ||||||
| dc.subject | Cognitive impairment | ||||||
| dc.subject | ERK | ||||||
| dc.subject | PTSD | ||||||
| dc.subject | Quetiapine | ||||||
| dc.title | Quetiapine ameliorates anxiety-like behavior and cognitive impairments in stressed rats: Implications for the treatment of posttraumatic stress disorder | ||||||
| dc.type | Article |
Author Affiliations
- Xijing Hospital
- The University of Hong Kong
- The Fourth Military Medical University