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Article: A polymorphism of apolipoprotein E (APOE) gene is associated with age at natural menopause in Caucasian females

TitleA polymorphism of apolipoprotein E (APOE) gene is associated with age at natural menopause in Caucasian females
Authors
He, LNRecker, RRDeng, HWDvornyk, V
KeywordsAge at natural menopause (ANM)
APOE
Association
Polymorphism
Issue Date2009
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/maturitas
Citation
Maturitas, 2009, v. 62 n. 1, p. 37-41 How to Cite?
DOI: http://dx.doi.org/10.1016/j.maturitas.2008.10.011
AbstractObjective: The present study aimed to investigate possible association of the apolipoprotein E (APOE) gene polymorphisms with age at natural menopause (ANM) in Caucasian females. Design: Four SNPs (including two replacements, SNP3 Cys112Arg and SNP4 Arg158Cys) were genotyped in 253 randomly selected unrelated Caucasian women having experienced natural menopause. The comprehensive statistical analyses focusing on the association of the APOE gene and some environmental factors with ANM were conducted. Results: Alcohol consumption was a significantly predictor of earlier natural menopause (P < 0.05). One SNP (rs769450) was significantly associated with ANM according to both population based and the transmission disequilibrium test (TDT) analyses (P = 0.007 and 0.046, respectively). However, no association was observed between APOE ε2, ε3, ε4 and ANM. Conclusions: Genetic variation in the APOE gene may influence the variation in ANM in Caucasian women. © 2008 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/60731
ISSN
0378-5122
2023 Impact Factor: 3.9
2023 SCImago Journal Rankings: 1.280
ISI Accession Number ID
WOS:000263609400006
Funding AgencyGrant Number
NIHR01 AR050496
K01 AR02170-01
R01 AR45349-01
R01 GM60402-01A1
State of NebraskaLB595
National Science Foundation of China
Huo Ying Dong Education Foundation
HuNan Province
Xi'an Jiaotong University
Ministry of Education of China
Funding Information:

Investigators of this work were partially supported by grants from NIH (R01 AR050496, K01 AR02170-01, R01 AR45349-01, and R01 GM60402-01A1) and an LB595 grant from the State of Nebraska. The study also benefited from grants from National Science Foundation of China, Huo Ying Dong Education Foundation, HuNan Province, Xi'an Jiaotong University, and the Ministry of Education of China.

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorHe, LNen_HK
dc.contributor.authorRecker, RRen_HK
dc.contributor.authorDeng, HWen_HK
dc.contributor.authorDvornyk, Ven_HK
dc.date.accessioned2010-05-31T04:17:19Z-
dc.date.available2010-05-31T04:17:19Z-
dc.date.issued2009en_HK
dc.identifier.citationMaturitas, 2009, v. 62 n. 1, p. 37-41en_HK
dc.identifier.issn0378-5122en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60731-
dc.description.abstractObjective: The present study aimed to investigate possible association of the apolipoprotein E (APOE) gene polymorphisms with age at natural menopause (ANM) in Caucasian females. Design: Four SNPs (including two replacements, SNP3 Cys112Arg and SNP4 Arg158Cys) were genotyped in 253 randomly selected unrelated Caucasian women having experienced natural menopause. The comprehensive statistical analyses focusing on the association of the APOE gene and some environmental factors with ANM were conducted. Results: Alcohol consumption was a significantly predictor of earlier natural menopause (P < 0.05). One SNP (rs769450) was significantly associated with ANM according to both population based and the transmission disequilibrium test (TDT) analyses (P = 0.007 and 0.046, respectively). However, no association was observed between APOE ε2, ε3, ε4 and ANM. Conclusions: Genetic variation in the APOE gene may influence the variation in ANM in Caucasian women. © 2008 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/maturitasen_HK
dc.relation.ispartofMaturitasen_HK
dc.rightsMaturitas. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectAge at natural menopause (ANM)en_HK
dc.subjectAPOEen_HK
dc.subjectAssociationen_HK
dc.subjectPolymorphismen_HK
dc.titleA polymorphism of apolipoprotein E (APOE) gene is associated with age at natural menopause in Caucasian femalesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0378-5122&volume=62&spage=37&epage=41&date=2009&atitle=A+polymorphism+of+apolipoprotein+E+(APOE)+gene+is+associated+with+age+at natural+menopause+in+Caucasian+femalesen_HK
dc.identifier.emailDvornyk, V: dvornyk@hku.hken_HK
dc.identifier.authorityDvornyk, V=rp00693en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.maturitas.2008.10.011en_HK
dc.identifier.pmid19058936-
dc.identifier.scopuseid_2-s2.0-58549102311en_HK
dc.identifier.hkuros154334en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-58549102311&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume62en_HK
dc.identifier.issue1en_HK
dc.identifier.spage37en_HK
dc.identifier.epage41en_HK
dc.identifier.isiWOS:000263609400006-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridHe, LN=37098859200en_HK
dc.identifier.scopusauthoridRecker, RR=7007086875en_HK
dc.identifier.scopusauthoridDeng, HW=7401775190en_HK
dc.identifier.scopusauthoridDvornyk, V=6701789786en_HK
dc.identifier.issnl0378-5122-

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