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Article: The small intestine proteome is changed in preterm pigs developing necrotizing enterocolitis in response to formula feeding

TitleThe small intestine proteome is changed in preterm pigs developing necrotizing enterocolitis in response to formula feeding
Authors
Issue Date2008
PublisherAmerican Society for Nutrition. The Journal's web site is located at http://jn.nutrition.org
Citation
Journal Of Nutrition, 2008, v. 138 n. 10, p. 1895-1901 How to Cite?
AbstractNecrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in newborn premature infants. Clinical studies show increased incidence of NEC in premature infants with enteral formula feeding; however, pathogenesis remains unclear. To identify the NEC-related proteins for molecular mechanisms, we applied proteomics analysis to characterize changes in the protein expression profile of newborn premature piglet intestines with NEC developed after enteral formula feeding for 24 h. Changes in protein expression were identified using 2-dimensional gel electrophoresis and peptide mass fingerprinting with MS as well as western blotting analysis. Nineteen differentially expressed proteins were identified and these have roles in oxidative stress, chaperone, signal transduction, protein folding and degradation, oxygen transport, signal transduction, and energy metabolism. Proteins with increased levels include manganese-containing superoxide dismutase and hemoglobin subunit and proteins with decreased expression include sorbitol dehydrogenase, mitochondrial aldehyde dehydrogenase 2, glucose-regulated protein 75, CRY protein, snail homolog 3, thyroid hormone-binding protein precursor, and DJ1 (Parkinson's disease 7) etc. The data provided novel mechanistic insights into the pathogenesis of NEC and the insults of a formulated diet to the premature gut. © 2008 American Society for Nutrition.
Persistent Identifierhttp://hdl.handle.net/10722/60706
ISSN
2015 Impact Factor: 3.74
2015 SCImago Journal Rankings: 2.040
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJiang, Pen_HK
dc.contributor.authorSiggers, JLAen_HK
dc.contributor.authorNgai, HHYen_HK
dc.contributor.authorSit, WHen_HK
dc.contributor.authorSangild, PTen_HK
dc.contributor.authorWan, JMFen_HK
dc.date.accessioned2010-05-31T04:16:52Z-
dc.date.available2010-05-31T04:16:52Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Nutrition, 2008, v. 138 n. 10, p. 1895-1901en_HK
dc.identifier.issn0022-3166en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60706-
dc.description.abstractNecrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in newborn premature infants. Clinical studies show increased incidence of NEC in premature infants with enteral formula feeding; however, pathogenesis remains unclear. To identify the NEC-related proteins for molecular mechanisms, we applied proteomics analysis to characterize changes in the protein expression profile of newborn premature piglet intestines with NEC developed after enteral formula feeding for 24 h. Changes in protein expression were identified using 2-dimensional gel electrophoresis and peptide mass fingerprinting with MS as well as western blotting analysis. Nineteen differentially expressed proteins were identified and these have roles in oxidative stress, chaperone, signal transduction, protein folding and degradation, oxygen transport, signal transduction, and energy metabolism. Proteins with increased levels include manganese-containing superoxide dismutase and hemoglobin subunit and proteins with decreased expression include sorbitol dehydrogenase, mitochondrial aldehyde dehydrogenase 2, glucose-regulated protein 75, CRY protein, snail homolog 3, thyroid hormone-binding protein precursor, and DJ1 (Parkinson's disease 7) etc. The data provided novel mechanistic insights into the pathogenesis of NEC and the insults of a formulated diet to the premature gut. © 2008 American Society for Nutrition.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Nutrition. The Journal's web site is located at http://jn.nutrition.orgen_HK
dc.relation.ispartofJournal of Nutritionen_HK
dc.titleThe small intestine proteome is changed in preterm pigs developing necrotizing enterocolitis in response to formula feedingen_HK
dc.typeArticleen_HK
dc.identifier.emailWan, JMF: jmfwan@hku.hken_HK
dc.identifier.authorityWan, JMF=rp00798en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid18806098-
dc.identifier.scopuseid_2-s2.0-54749112307en_HK
dc.identifier.hkuros154348en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-54749112307&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume138en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1895en_HK
dc.identifier.epage1901en_HK
dc.identifier.isiWOS:000259554500010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridJiang, P=36147603700en_HK
dc.identifier.scopusauthoridSiggers, JLA=24554223000en_HK
dc.identifier.scopusauthoridNgai, HHY=8528923200en_HK
dc.identifier.scopusauthoridSit, WH=8528923000en_HK
dc.identifier.scopusauthoridSangild, PT=7004115316en_HK
dc.identifier.scopusauthoridWan, JMF=8930305000en_HK

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